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Preparation method of Chinese herb medicine compound for treating coronary heart disease

A technology of coronary heart disease and traditional Chinese medicine, which is applied in the field of preparation of traditional Chinese medicine compound for the treatment of coronary heart disease. The effect of increasing drug loading

Inactive Publication Date: 2010-02-17
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation limitations of the original process are as follows: 1. The retention rate of some medicinal materials is low in water extraction and alcohol precipitation; 2. Some medicinal materials are crushed into medicine, and the process is rough; 3. The volatile oil is directly sprayed on the granules, resulting in "oily" capsules and volatile oil storage. The defect of loss in the process; 4. The yield of ointment is high, the drug loading of the finished product is low, and the dosage at one time is large

Method used

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  • Preparation method of Chinese herb medicine compound for treating coronary heart disease
  • Preparation method of Chinese herb medicine compound for treating coronary heart disease
  • Preparation method of Chinese herb medicine compound for treating coronary heart disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0096] Example 1: A preparation method of a traditional Chinese medicine compound for the treatment of coronary heart disease, selecting Geshanxiang 1667g; holly 1667g; hair musk 833g; calamus 500g; epimedium 333g; notoginseng 33.3g; evodia 33.3g; borneol 1.67g total Eight-flavor medicinal materials, among them, add 5 times the amount of water to Shanxiang, Maodongqing, Epimedium, and Panax notoginseng, heat and reflux twice for 0.5 hours each time, filter, combine the filtrate, and recover ethanol under reduced pressure at 80°C to a relative density of 1.08. AB-8 macroporous adsorption resin column, washed with water until the sugar reaction is negative, followed by elution with 70% ethanol, collect the alcohol washing solution, recover the ethanol under reduced pressure at 80°C to obtain a concentrated solution with a relative density of 1.08, spray dried to obtain powder ; Evodia, calamus, and musk musk use supercritical CO 2 Extract the extract, spray dried powder, borneol, ...

Embodiment 2

[0097] Example 2: A preparation method of a traditional Chinese medicine compound for the treatment of coronary heart disease, selecting 1667g Geshanxiang; 1667g gladiolus; 833g wool musk; 500g calamus; Epimedium 333g; Panax notoginseng 33.3g; Evodia 33.3g; borneol 1.67g total Eight medicinal materials, of which 20 times the amount of Shanxiang, Maodongqing, Epimedium and Panax notoginseng were added with water, heated and refluxed 3 times for 1 hour each time, filtered, combined the filtrate, and recovered ethanol under reduced pressure at 80°C to a relative density of 1.10, and passed AB-8 macroporous adsorption resin column, washed with water until the sugar reaction is negative, followed by elution with 95% ethanol, collect the alcohol washing solution, recover the ethanol under reduced pressure at 80°C to obtain a concentrated solution with a relative density of 1.10, spray dried to obtain powder ; Evodia, calamus, and musk musk use supercritical CO 2 Extract the extract, s...

Embodiment 3

[0098] Example 3: A preparation method of a traditional Chinese medicine compound for the treatment of coronary heart disease, selecting Geshanxiang 1667g; holly 1667g; hair musk 833g; calamus 500g; epimedium 333g; notoginseng 33.3g; evodia 33.3g; borneol 1.67g total Eight-flavor medicinal materials, among them, Geshanxiang, Maodongqing, Epimedium, Panax notoginseng, add 10 times the amount of 70% ethanol, heat and reflux for 2 times, 2 hours each time, filter, combine the filtrate, and recover ethanol to relative density under reduced pressure at 80°C 1.08~1.10, through AB-8 macroporous adsorption resin column, washed with water until the sugar reaction is negative, followed by elution with 70% ethanol, collect the alcohol washing solution, and recover the ethanol under reduced pressure at 80°C to obtain a relative density of 1.08~1.10 Concentrated liquid, spray-dried to obtain medicinal powder; Evodia, calamus, and musk musk use supercritical CO 2 The extract is extracted, the...

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Abstract

The present invention discloses a preparation method of a Chinese herbal compound for treating coronary disease, including eight kinds of medicines: lemonfragrant ostericum root, hairy holly root, evodia rutaecarpa, grassleaved sweetflag, Adenosma glutinosum, epimedium herb, radix notoginseng and borneol. Wherein, lemonfragrant ostericum root, hairy holly root, epimedium herb and radix notoginsengare added with water or the mixture of water and ethanol in different proportion 5 to 20 times, heated and returned for 2 to 3 times and filtered once every 0.5 to 2 hours; the filtrate is combined and the ethanol is recovered by decompression at 80 degrees to the relative density of 1.08 to 1.10; through an AB-8 macroporous resin column, 70-95 percents ethanol is used for washing and the liquidis collected; a condensed liquid of 1.08 to 1.10relative density is obtained by recovering the ethanol by decompression at 80 degrees and a medicine power is obtained by spraying and drying; evodia rutaecarpa, grassleaved sweetflag and Adenosma glutinosum are extracted by supercritical CO2, then the medicine powder, borneol and extract by supercritical CO2, added with medicinal auxiliaries or formulation agents are mixed to get various dosage forms. The present invention can effectively lower the paste rate of the dosage form, increase the medicine carrying capacity of finished products, reduce the damage of the original process to the effective ingredients of the present invention and improving the retention rate of the effective ingredients.

Description

Technical field [0001] The invention relates to a preparation method of a traditional Chinese medicine compound for treating coronary heart disease. Background technique [0002] Huxin Capsule Recipe is a ministry-issued standard traditional Chinese medicine prescription that has been proven to be effective in treating coronary heart disease through many years of clinical practice. It can be used to treat and prevent chest tingling, colic, chest tightness, shortness of breath, palpitations, and sweating caused by heart blood stasis or heart-yang deficiency. , Chills, cold limbs, sore waist and knees. At present, the types of commercially available preparations are mainly capsules made by steam distillation combined with water extraction and alcohol precipitation and crude drug smashing process. 1667 parts by weight of Geshanxiang; 1667 parts by weight of holly moss; 833 parts by weight of musk; 500 parts by weight of calamus Parts; Epimedium 333 parts by weight; Panax notoginsen...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/888A61K36/80A61K36/754A61K36/296A61K36/258A61K36/23A61K36/185A61P9/10A61K31/045A61K35/55
Inventor 张军陈建南原素赖小平
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE