Bone tissue repairing material and its preparation method

Abstract

A porous bone tissue repairing material with high biocompatibility, degradability, mechanical strength and toughness is prepared from collagen A, strontium polyphosphate (SRPP) and calcium polyphosphate (CPP) through mixing, freeze-drying and sterilizing by epoxy ethane.

Description

1. Technical field [0001] The invention relates to the technical field of biomedical materials, in particular to the technical field of biomedical engineering suitable for repairing human hard tissue defects by bone tissue. 2. Background technology [0002] At present, there are many studies on orthopedic repair materials at home and abroad, including polymer materials and biomaterials, among which polymer materials include PLA, PGA and PLA / PGA copolymers, etc. PGA and PLA are both esters. More, the United States PDA has been approved for marketing and used in clinical biodegradable medical polymer materials, with good biocompatibility, degradability and absorbability. Its disadvantage is poor hydrophilicity, resulting in The acidic product will reduce the pH value around the polymer, the mechanical strength is insufficient, and the mechanical strength loses too fast during the degradation process, so it cannot fully play the role of scaffold during bone tissue repair. Bioc...

AI Technical Summary

Problems solved by technology

The disadvantage is that it is brittle, not flexible enough, and difficult to degrade

Tricalcium phosphate has good biocompatibility and osteoconductivity, but its disadvantage is that it is brittle, and the degradation rate of tricalcium phosphate is too fast, and the degradation rate cannot be changed according to the needs of cells. Therefore, it has no real medical practical value.

[0003] Calcium polyphosphate (CPP) is an inorganic polymer with a molecular formula of [Ca(PO)z]n and a density of 2.85 / cm3. This polymer is different from general organic polymers. Its main chain structure It is not connected by a simple covalent bond, but is connected by [PO3] ions in the four-in-body structure. Therefore, the characteristics of the polymer can be used to affect its performance by changing the structural parameters such as the degree of polymerization of the material; at the same time Calcium ions and [PO3] are combined with each other by ionic bonds, so it can also be used as an inorganic material to study materials. In recent years, calcium polyphosphate has been studied as a bone scaffold at home and abroad. Canadian Pillar et al. found that The material has the advantages of good biocompatibility and controllable degradation. Lanzhou Railway Institute Chang Qing and others have conducted some research on polyphosphorus calcium amorphous fiber as a reinforcing material. However, the strength and toughness of the material need to be improved.