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Preparation method of sustained release formulation for treating echinococcosis

A technology for sustained-release preparations and hydatid disease, which is used in drug combination, drug delivery, and pharmaceutical formulations, etc., can solve the problems of uncertain drug loading per unit preparation, affecting the stability of drug preparations, and non-repeatable preparation process. The effect of reducing production costs, improving accuracy, and saving production costs

Inactive Publication Date: 2007-08-01
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"The inclusion of biocompatible materials not only effectively increases the drug loading capacity, but also significantly improves the utilization rate and action time of the drug through subcutaneous implantation or intramuscular injection. However, the preparation of the above-mentioned inclusion preparation There are still at least two deficiencies: ① A large amount of organic solvents are used in the inclusion process, and the residue of organic solvents will affect the stability of the pharmaceutical preparation ② It is difficult to ensure that the drug is completely encapsulated by the material during the inclusion process. The drug loading is uncertain, and the preparation process is not reproducible

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Weigh 0.2g of anti-echinococcosis drug praziquantel and 199.8g of biocompatible material PLGA (the content ratio of polylactic acid and polyglycolic acid is 85:15) with 0.1% theoretical drug loading;

[0022] (2) PLGA, a biocompatible material, was put into an internal mixer heated to 180°C and stirred for 20 minutes;

[0023] (3) Praziquantel is dropped into the molten material and continues to stir for 20 minutes;

[0024] (4) The mixture of praziquantel and PLGA is taken out from the internal mixer and cooled at room temperature to form a solid dispersion;

[0025] (5) The solid dispersion is melt-extruded at 180° C. to form a cylindrical slow-release implant.

[0026] Implementation effect: the slow-release implant prepared by the present invention has no organic solvent residue, accurate dosage, and can release medicine steadily and slowly for 300-500 days in dogs.

Embodiment 2

[0028] (1) Weigh 20g of the anti-echinococcosis drug mebendazole and 80g of the biocompatible material PCL (polycaprolactone, with a weight average molecular weight of 50,000) at 20% theoretical drug loading;

[0029] (2) PCL, a biocompatible material, was put into an internal mixer heated to 60°C and stirred for 10 minutes;

[0030] (3) Mebendazole is dropped into the molten material and continues to stir for 25 minutes;

[0031] (4) The mixture of mebendazole and PCL is taken out from the internal mixer and cooled at room temperature to form a solid dispersion;

[0032] (5) The solid dispersion is melt-extruded at 60° C. to form an oval sustained-release implant.

[0033] Implementation effect: the slow-release implant prepared by the present invention has no organic solvent residue, accurate dosage, and can release medicine steadily and slowly for 300-500 days in dogs.

Embodiment 3

[0035] (1) 40% theoretical drug loading weighs 100g anti-hydatid drug levamisole hydrochloride and 150g biocompatible material polyethylene terephthalate (polyethylene terephthalate, weight average molecular weight is 100000);

[0036] (2) The biocompatible material polyethylene terephthalate is put into an internal mixer heated to 150° C. and stirred for 15 minutes;

[0037] (3) levamisole hydrochloride was dropped into the molten material, and continued to stir for 30 minutes;

[0038] (4) The mixture of levamisole hydrochloride and polyethylene terephthalate is taken out from the internal mixer and cooled at room temperature to form a solid dispersion;

[0039] (5) The solid dispersion is melt-extruded at 150° C. to form a conical slow-release implant.

[0040] Implementation effect: the slow-release implant prepared by the present invention has no organic solvent residue, accurate dosage, and can release medicine steadily and slowly for 300-500 days in dogs.

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PUM

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Abstract

The invention discloses a making method of echinococcosis drug slow-release agent, which comprises the following steps: 1. allocating raw material and biological compatible material; 2. putting biological compatible material into dense fusing machine to stir until the material is fused completely; 3. putting raw material drug into the fused material to stir continuously; 4. blending drug and material completely; fetching the composition out of dense fusing machine; cooling under indoor temperature to form even solid dispersant; 5. grinding solid dispersant; pressing directly; or squeezing through mould after fusing; obtaining the product.

Description

technical field [0001] The invention relates to a preparation method of a preparation, in particular to a preparation method of an echinococcosis medicine slow-release preparation. It belongs to the technical field of pharmaceutical engineering. Background technique [0002] Hydatid disease is a common parasitic disease of livestock, which is widely prevalent in the agricultural and pastoral areas of western my country. Hydatid disease mainly parasitizes in important organs such as the liver and lungs of livestock, forms cysts of different sizes, destroys the normal structure of tissues, and eventually leads to the death of livestock. At present, the pharmaceutical preparations for the treatment and prevention of livestock echinococcosis are mainly tablets, such as praziquantel tablets and albendazole tablets. Although tablets have many advantages such as accurate dosage, uniform content, good stability, and high degree of production automation, they have relatively large ...

Claims

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Application Information

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IPC IPC(8): A61K45/00A61K31/167A61K31/4164A61K31/4184A61K31/4985A61K47/32A61K47/34A61K47/36A61K47/38A61K47/42A61K9/00A61K9/20A61P33/14
Inventor 郭圣荣程亮
Owner SHANGHAI JIAO TONG UNIV
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