Organic amine salt of cephalosporin compound and its preparation method

Abstract

The invention relates to the organic amine salt or hydrate for ceph compound used for treating bacteria infection, and the chemical formula is demonstrated in (I).Said organic amine can be lycine, arginine, tert-butylamine, diethanolamine, triethanolamine, diethylamine or meglumine. It comprises cefuroxime organic amine salt, ceftriaxone organic amine salt, ceftezole organic amine salt, cefoperazone organic amine salt, cephalothin organic amine salt, cefotaxime organic amine salt, cefradine organic amine salt, cefonicid organic amine salt, cefmetazole organic amine salt, cefodizime organic amine salt, cefmenoxime organic amine salt, ceftizoxime organic amine salt, cefpiramide organic amine salt, cefazolin organic amine salt, cefoxitinorganic amine salt and flomoxef organic amine salr. The invention provides the medical compound taking compound in formula (I) as active element and its application to preparation of medicine for treating bacteria infection.

Description

Technical field: [0001] The invention belongs to the field of compound medicine and relates to derivatives of cephalosporin compounds and a preparation method thereof. Background technique: [0002] Since cephalosporin C was chemically separated and lysed into the important intermediate body 7ACA in 1961, semi-synthetic cephalosporin drugs have developed rapidly. The first generation of cephalosporins such as cephalethin, cephalexin, and cefradine in the early stage. Cefuroxime, cefamandole and cefoxitin are second-generation cephalosporins. In 1977, the West German Hoechst Company and the French Rousll Company jointly developed a cefotaxime (cefotaxime, HR756) with excellent antibacterial activity. Since then, the development of cephalosporins has entered the third generation, and the research on cephalosporins has achieved significant results. [0003] However, with the widespread use of cephalosporins, it has been found that most cephalosporins have drug resistance and have to...

AI Technical Summary

Problems solved by technology

[0003] However, with the widespread use of cephalosporins, it is found that most cephalosporins will produce drug resistance and have toxic side effects

There are many problems in the use process, such as: 1) there is vascular irritation, and long-term use can easily cause symptoms such as vasculitis; 2) most of them exist in the form of sodium salts, and sodium ions enter the human body in such a large amount Patients with diabetic bacterial infection, neurosurgery patients with severe neurosurgery, patients with heart and kidney insufficiency, or patients with high blood pressure are at high risk, which can easily cause hypernatremia and cause adverse reactions; 3) Some varieties have incompatibility and are inconvenient to use; 4) Muscle There is muscle irritation when injecting; etc.

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