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Ginnone ester dispersing table and its preparation method

A technology of ginkgo ketone esters and dispersible tablets is applied in the directions of medical raw materials derived from Ginkgo biloba, pill delivery, cardiovascular system diseases, etc. Good, beneficial to long-term use, convenient transportation and storage

Active Publication Date: 2011-05-04
JIANGSU SHENLONG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In summary: the single and unreasonable dosage form seriously restricts the clinical application of ginkgo ketone ester

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] The ginkgo ketone ester raw material is pulverized, sieved, weighed 400g, added 100ml of 20% polyacrylic acid resin IV ethanol solution to make a soft material, granulated, dried, and sized to obtain ginkgo ketone ester microcapsules.

[0061] Grind the remaining auxiliary materials, sieve, weigh 800 grams of calcium hydrogen phosphate, 200 grams of low-substituted hydroxypropyl cellulose, 50 grams of starch, and 30 grams of sucrose, and use 25% ethanol solution as a wetting agent to mix the The auxiliary material powder is made into a soft material, granulated, dried, and granulated to obtain auxiliary material granules.

[0062] The ginkgo ketone ester microcapsules and auxiliary material granules are evenly mixed, and compressed into tablets to obtain a finished product.

Embodiment 2

[0064] The ginkgo ketone ester raw material is pulverized, sieved, weighed 400g, added 100ml of 20% polyacrylic acid resin IV ethanol solution to make a soft material, granulated, dried, and sized to obtain ginkgo ketone ester microcapsules.

[0065] Grind the rest of the required auxiliary materials, sieve, weigh 750 grams of calcium hydrogen phosphate, 250 grams of low-substituted hydroxypropyl cellulose, 70 grams of lactose, and 30 grams of glucose, and use 25% ethanol solution as a wetting agent to mix the The auxiliary material powder is made into a soft material, granulated, dried, and granulated to obtain auxiliary material granules.

[0066] The ginkgo ketone ester microcapsules and auxiliary material granules are evenly mixed, and compressed into tablets to obtain a finished product.

Embodiment 3

[0068] The ginkgo ketone ester raw material is pulverized, sieved, weighed 400g, added 100ml of 20% polyacrylic acid resin IV ethanol solution to make a soft material, granulated, dried, and sized to obtain ginkgo ketone ester microcapsules.

[0069] Pulverize the rest of the required auxiliary materials, sieve, weigh 720 grams of calcium hydrogen phosphate, 275 grams of low-substituted hydroxypropyl cellulose, 90 grams of microcrystalline cellulose, and 15 grams of aspartame, and use 25% ethanol solution to moisten The wet agent makes the mixed auxiliary material powder into a soft material, granulates, dries, and granulates to obtain auxiliary material granules.

[0070] The ginkgo ketone ester microcapsules and auxiliary material granules are evenly mixed, and compressed into tablets to obtain a finished product.

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PUM

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Abstract

The present invention is ginnone ester dispersing table with good taste, high dispersivity, high dissolution and high bioavailability and its preparation process. The ginnone ester dispersing table consists of ginnone ester 40 weight portions, polyacrylate resin 2-4 weight portions, calcium hydrophosphate 60-80 weight portions, low substituted hydroxypropyl cellulose 20-40 weight portions, filler5-15 weight portions, and corrective 1-3 weight portions.

Description

technical field [0001] The invention relates to a ginkgo ketone ester dispersible tablet preparation and a preparation method thereof, belonging to the technical field of traditional Chinese medicine pharmacy. Background technique [0002] Ginkgo is a plant of the Ginkgo family Ginkgo family. Ginkgo biloba is a common Chinese medicinal material. It has the functions of astringing exhaust gas, relieving asthma and cough, and relieving turbidity. It is used for lung deficiency cough, coronary heart disease, angina pectoris and other diseases. Ginkgo has been used as medicine for thousands of years in my country. But the research on the chemical constituents and pharmacological effects of Ginkgo biloba extract began in the 1960s. Studies have shown that: Ginkgo biloba extract mainly contains ginkgo flavonoid glycosides, terpenoid lactones and other components. Among them, ginkgo terpene lactones have obvious activity of antagonizing platelet activating factor (PAF), and with...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K36/16A61P9/10
Inventor 胡传良
Owner JIANGSU SHENLONG PHARMA
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