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Asarone slow-release capsule and its preparing method

A technology of sustained-release capsules and Asarum, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, and drug delivery, can solve the problems of short half-life and low bioavailability, and achieve complete absorption and high bioavailability. , the effect of stable blood concentration

Inactive Publication Date: 2007-08-29
XINMA MEDICINE SCI TECH SHENYANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The current dosage forms of asarone include injections, tablets and capsules, etc., but because asarone is insoluble in water, its bioavailability is low, and its half-life is short, so frequent administration is required

Method used

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Examples

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Effect test

preparation example Construction

[0012] The present invention is the preparation of Asarum sustained-release capsules:

[0013] 1. Preparation of drug-containing pellets:

[0014] Asarone 300mg, microcrystalline cellulose 125mg, povidone 12.5mg, water 1ml, and asarone and povidone aqueous solution are loaded on the blank core by fluidized bed technology to make drug-containing pellets.

[0015] 2. Preparation of slow-release microparticles

[0016] Take 33 mg of ethyl cellulose, 3.3 mg of diethyl phthalate, and 0.33 ml of ethanol to make a coating solution, and coat the drug-containing pellets with the coating solution to make sustained-release particles.

[0017] 3. Put the slow-release particles on the capsule shell

[0018] The sustained-release microparticles are filled into No. 1 capsules to make sustained-release capsules.

Embodiment 2

[0019] Embodiment two: the preparation of asarone sustained-release capsules

[0020] 1. Preparation of drug-containing pellets

[0021] Take asarone 300mg, sodium carboxymethylcellulose 100mg, hydroxypropyl methylcellulose 50mg, crystal cellulose 25mg, appropriate amount of water, mix them well, and put them in a spherical pellet granulator to make drug-containing pellets. pill.

[0022] 2. Preparation of slow-release microparticles

[0023] Take 85mg of Eudragit PS100, 8.5mg of triethyl citrate, 1.7mg of polyethylene glycol 6000, and 0.85ml of ethanol to make a coating solution, and coat the drug-containing pellets with the coating solution to make sustained-release microparticles.

[0024] 3. Put the sustained-release capsule particles into the capsule shell

[0025] Sustained-release microparticles are filled into zero-size capsules to make sustained-release capsules.

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PUM

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Abstract

The present invention relates to an asarone slow-release capsule and its preparation method. The asarone has the functions of relieving cough, reducing sputum and relieving asthma and used for curing disease of bronchospasm due to histamine and acetylcholine. Its prescription composition includes asarone, blank pill core, blocking agent, slow-release film-forming material, filling agent, plasticizer and pore-forming agent, and its preparation method includes the following steps: using blank pill core as carrier, adding medicine (containing blocking agent) to obtain medicine-contained micropill, coating said micropill with slow-release film-forming material to obtain slow-release microparticle, plasing the microparticles into capsule shell so as to obtain the invented asarone slow-release capsule.

Description

technical field [0001] The invention relates to a dosage form of medicine, in particular to an asarone sustained-release capsule and a preparation method thereof. Background technique [0002] Asarone, also known as a-asarone and a-asarone, mainly exists in the volatile oil of plants such as calamus calamus. Since the 1960s, a-asarone has been widely studied at home and abroad, and it has been confirmed that it has strong pharmacological activity, and has cough-relieving, expectorant, asthma-relieving, sedative, antispasmodic and anticonvulsant effects. It also has different degrees of inhibitory effect on the growth of pneumococcus, staphylococcus aureus and Escherichia coli. The extracted monomers have been clinically applied to pneumonia, asthma, grand mal epilepsy, etc. and have received good results. Clinical studies have been conducted on asarone at home and abroad. This product has low toxicity and no addiction. The blood concentration reaches the peak after 15 minu...

Claims

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Application Information

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IPC IPC(8): A61K31/09A61K36/882A61K9/52A61P11/06A61P11/10A61P11/14
Inventor 李献阳
Owner XINMA MEDICINE SCI TECH SHENYANG
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