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Technology for extracting Baicalin

A technology of baicalin and baicalin, which is applied in the field of extraction technology of raw materials of traditional Chinese medicine, and can solve the problems of low extraction, transformation and utilization of Scutellaria baicalensis

Inactive Publication Date: 2007-08-29
王丽萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, at present, there are many enzymatic hydrolysis methods (Chinese Patent Application Nos. 200310109290.5, 200310110338.4, 200410024693.4), the process is relatively simple, and the conditions are mild, but there are also problems of low extraction and conversion of Scutellaria baicalensis medicinal materials and low utilization rate.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Prepare 600 ml of 7% aqueous solution with concentrated hydrochloric acid, add 20 grams of baicalin, stir, place in a 1-liter high-pressure reactor, feed nitrogen, increase the pressure while heating, and reflux between 90 ° C and 110 ° C for 2.5 hour, keep the pressure at 5bar, after the reaction is over, filter the solution after cooling to obtain light yellow baicalinin crude product, dissolve it by heating with 300 ml of methanol, filter, concentrate under reduced pressure to dryness, and then recrystallize with 85% ethanol, Vacuum drying to obtain baicalin.

Embodiment 2

[0014] First configure 3000 ml of 7% sulfuric acid ethanol solution (containing 45% ethanol), add 150 grams of baicalin and stir, place in an acid-resistant high-pressure reactor with a volume of 5 liters, feed nitrogen to increase the pressure, and heat at the same time, at 70-100 Reflux at ℃ for 1.0 hour and keep the pressure at 12 bar. After the reaction, the solution is cooled and filtered to obtain the crude product of light yellow baicalin. Add 500 ml of pure water to the crude product and stir well, then add 1000 ml of ethyl acetate and shake well to extract, remove The aqueous layer was repeated twice, and the organic layers were combined, concentrated to dryness under reduced pressure, dried in vacuo, and isolated to obtain baicalin.

Embodiment 3

[0016] First prepare 550 ml of 10% sulfuric acid aqueous solution, add 20 g of baicalin, place it in a 1-liter high-pressure reactor lined with polytetrafluoroethylene, feed nitrogen to increase the pressure, and heat at the same time, reflux at 80-100 ° C for 1.5 hours, Keep the pressure at 25 bar. After the reaction, the solution is cooled and filtered to obtain the crude product of light yellow baicalin. Add 100 ml of pure water to the crude product and stir well, then add 200 ml of ethyl acetate, shake well and extract, remove the water layer, and repeat Twice, the organic layers were combined, concentrated to dryness under reduced pressure, dried in vacuo, and isolated to obtain baicalin.

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PUM

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Abstract

The invention relates to a method to make baicalin aglycon from baicalin. It uses baicalin as raw material, and mixing 3-30% acid to make solution containing 1-20% baicalin. In the pressure proofing and acid proofing reactor, taking pressure hydrolysis (pressure at 0.1-100bar), taking inert gas protection, reacting for 0.1-8 hours at 60-140 degree centigrade, cooling to room temperature, filtering to gain baicalin aglycon raw material, taking organic solvent purification process, the baicalin aglycon would be gained.

Description

technical field [0001] The invention relates to a raw material drug extraction process of traditional Chinese medicine, in particular to a baicalinin extraction process. Background technique [0002] Scutellaria baicalensis is the dried root of Scutellaria baicalensis Georgi, a plant of the Labiatae family, and is one of the commonly used Chinese medicinal materials recorded in the Chinese Pharmacopoeia. Its nature is bitter, cold, returns to lung, gallbladder, spleen, large intestine, small intestine meridian, has clearing away heat and dampness, purging fire and detoxification, hemostasis, antiabortive effect. The active ingredients of Scutellaria baicalensis are flavonoids (more than 90%), mainly containing baicalin (baicalin), baicalein (baicalein), wogonside (wogonside), wogonin (wogonin), oroxylin A (oroxylin A) etc. [0003] Modern pharmacological and pharmacodynamic studies have shown that Scutellaria baicalensis extract and its chemical components have various and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/30
Inventor 王丽萍徐勃
Owner 王丽萍
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