Denaturated starch absorbable hemostatic material and preparation method thereof

A technology of modified starch and hemostatic materials, which can be applied in pharmaceutical formulations and drug delivery, and can solve the problems of affecting the hemostatic effect, low viscosity, and poor hemostatic effect, and achieve reliability, safety, clinical promotion value, and good biocompatibility , Improve the effect of hemostatic effect

Inactive Publication Date: 2008-02-13
美国淀粉医疗公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

First of all, from the aspect of application, this hemostatic material is mainly limited to the hemostasis of skin or soft tissue wounds, and the hemostasis of tissues and organs in the deep part of the body cavity, especially the hemostasis under endoscopy (such as minimally invasive endoscopy, colonoscopy and laparoscopy). During operation) still lack effective means; The 2nd, from preparation method, epichlorohydrin is colorless oily liquid, has irritating smell like ether and chloroform, has toxicity and anesthesia, therefore unfavorable to environmental protection, production cost Thirdly, in terms of hemostatic effect, its water absorption is not strong enough, the water absorption multiple is low, and the speed of water absorption is slow, especially for active bleeding.
Fourth, its viscosity is low, and the gel formed after absorbing water has poor viscosity. Therefore, the clot formed after interacting with blood has poor adhesion to tissues, and cannot effectively block damaged tissues and blood vessels, thus affecting hemostasis. Effect

Method used

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  • Denaturated starch absorbable hemostatic material and preparation method thereof
  • Denaturated starch absorbable hemostatic material and preparation method thereof
  • Denaturated starch absorbable hemostatic material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] A modified starch absorbable hemostatic material, including carboxymethyl starch (No.66), which is made of carboxymethyl starch raw material in a boiling machine at 40-50°C, adding distilled water, agglomerated and pelletized to make it porous particles. The No.66 product has a molecular weight of 15,000-2,000,000 and a particle size of 10-1000 μm, wherein starch granules with a particle size of 30-500 μm account for not less than 95% of the total starch granules, and more preferably a particle size of 50-250 μm , 37°C, 6.67% starch solution has a viscosity of 30-557.9mPa·s, and the viscosity work of modified starch at room temperature when it absorbs water and is saturated is 68.1g·mm.

[0055] See Figure 1Arista TM Granule 200 times magnification electron micrograph, Fig. 2 No.66 raw material carboxymethyl starch granule 300 times magnification electron micrograph and Fig. 3 No.66 shown in the carboxymethyl starch granule 50 times magnification electron micrograph of...

Embodiment 2

[0057] A modified starch absorbable hemostatic material, including hydroxyethyl starch (No.88). The raw material of hydroxyethyl starch is placed in a boiling machine at 40-50 ° C, distilled water is added, and after polymerization and pelletizing, porous particles are made. . The molecular weight of the hydroxyethyl starch product is 15,000-2,000,000, and the particle size is 10-1000 μm, wherein the starch granules with a particle size of 50-500 μm account for not less than 95% of the total starch granules, and more preferably the particle size is 50-500 μm. 250μm, 37℃, 6.67% starch solution has a viscosity of 30.6mPa·s, and the viscosity work of the modified starch at room temperature when it absorbs water and is saturated is 75.2g·mm.

[0058] The water absorption performance of the present invention is measured by a capillary measuring device, and water is poured into the acid burette so that the zero-scale liquid level of the acid burette is flush with the lower end of th...

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Abstract

An absorbable modified starch hemostatic material and preparation thereof, wherein the hemostatic material is etherified starch, or a mixture of one or more etherified starches, crosslinked starches. The modified starch has a molecular weight of 15,000 - 10,000,000, a particle size of 10 - 1000µm, and a water absorption rate of 1 - 100. The biocompatible hemostatic material can directly effect on the wound with blood, concentrate the blood quickly to congulate blood; moreover, the gelatiniform mixture formed with blood has high viscosity, which can plug damaged tissue and blood vessel. The biocompatible hemostatic material is easy to swell in the water and easy to be washed so that the residue can be reduced; it is stable, not easy to decompose, and has long shelf life and storage advantage. The biocompatible hemostatic material can also be used as absorbable surgical antisticking material, promoting tissue healing material, surgical sealant and wound no-joint tissue adhesive.

Description

technical field [0001] The invention relates to a modified starch absorbable hemostatic material and a preparation method thereof, in particular to a modified starch hemostatic material which is directly sprayed on bloody wounds of humans and mammals for hemostasis and can be absorbed by the human body. Background technique [0002] Surgical operations and trauma usually cause bloody wounds, resulting in a large amount of blood loss, which requires timely use of hemostatic means. Here are some commonly used surgical absorbable hemostatic materials. [0003] 1. Absorbable gelatin sponge and collagen sponge [0004] Gelatin sponge is derived from the extract of animal tissue, and its main component is animal collagen. Its hydrophilic and porous structure can quickly absorb the water in the blood and concentrate the blood, so as to achieve the purpose of hemostasis. However, gelatin is a collagen extract derived from animals and contains foreign proteins, which can easily cau...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28
CPCA61L2400/04C08L3/04C08L3/08A61L24/08C08L2205/02
Inventor 纪欣邢程史学深陈建萍
Owner 美国淀粉医疗公司
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