Chlorhexidine acetate partial film forming gel composition and uses thereof

Abstract

The present invention discloses a compound of an chlorhexidine acetate local membrane forming gel, which comprises the components of the following weight percentages comprising 0.5 percentage to 7 percentage of alkyl cellulose, 1 percentage to 10 percentage of etherifying agent, 0.5 percentage to 5 percentage of cross linking agent,75 percentage to 90 percentage of dissolvent, 0.01 percentage to 3 percentage of chlorhexidine acetate. The cross linking agent is the saturated fat or the alcoholic acid, the chemical general formula of which is CnH2n+2-m-l(OH)m(COOH)l. Among the formula, m or n or 1 is the integer and the n is no less than m, which is no less than 2. 1 is no less than 0 and the result of m plus 1 is 4 to 8. The result of n plus 1 is 4 to 8. In the present invention, the compound of the chlorhexidine acetate local membrane forming gel is applied in the treatment of the local infection in the mucosa or the skin. A water drain protective membrane with smooth property, firm property, wear-resisting property and duration property is formed on the surface of the ulcer when the present invention is applied. Compared with all kinds of local formulation of the chlorhexidine acetate, the membrane formed by the gel compound is not likely to experience fracture, dissolution or corrosion. The membrane has properties of long maintenance time and slow releasing of the medicine. The membrane can be effectively maintained in the skin surface for over 8 hours and the membrane can be effectively maintained on the mouth mucosa surface for over 5 hours.

Description

Technical field [0001] The invention relates to a local film-forming gel composition of chlorhexidine acetate and its application in the treatment of skin / mucosal local infectious diseases. Background technique [0002] Chlorhexidine Acetate (Chlorhexidine Acetate) is a kind of biguanide compound, also known as chlorhexidine acetate (Tai), chlorhexidine acetate, chlorphenidine acetate, etc. It belongs to disinfection, sterilization and antiseptic. It has a bactericidal effect by changing the permeability of the cytoplasmic membrane of the bacteria to leak out the cell contents, and it has a bactericidal effect against Staphylococcus cutaneous, Streptococcus mutans, Streptococcus salivarius, Escherichia coli, Propionibacterium and Candida albicans, etc. All have antibacterial activity. Common topical preparations of chlorhexidine acetate include solutions, gels, ointments and sprays. However, when chlorhexidine acetate in the above dosage form is used for local sterilization, due ...

AI Technical Summary

Problems solved by technology

However, we have found that the local film-forming gel composition made of monoglyceryl laurate as a cross-linking agent, although the flexibility of the film is enhanced, the time of adhesion to body tissues or mucous membranes is relatively short, as in The film formed on the oral mucosa is easily eroded / dissolved by body fluids or saliva, causing the film to rupture and fall off prematurely, so that it disappears quickly

[0007] Therefore, if adopting the technology of above-mentioned existing film-forming gel composition to prepare chlorhexidine acetate local film-forming gel, the retention time of medicament and affected part will be shorter, and affect therapeutic effect

Images