Chlorhexidine acetate partial film forming gel composition and uses thereof

A technology of chlorhexidine acetate and gel composition, which is applied in the direction of drug combination, medical preparations with no active ingredients, medical preparations containing active ingredients, etc., can solve problems such as short time, membrane rupture, and shedding, and achieve Easy to obtain raw materials, good biocompatibility and good flexibility

Inactive Publication Date: 2008-03-12
SHANGHAI INST OF PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, we have found that the local film-forming gel composition made of monoglyceryl laurate as a cross-linking agent, although the flexibility of the film is enhanced, the time of adhesion to body tissues or mucous membranes is relatively short, as in The film formed on the oral mucosa is easily eroded/dissolved by body fluids or saliv

Method used

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  • Chlorhexidine acetate partial film forming gel composition and uses thereof
  • Chlorhexidine acetate partial film forming gel composition and uses thereof
  • Chlorhexidine acetate partial film forming gel composition and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～16

[0037] Examples 1-16 and comparative examples

[0038] Respectively, the amount of chlorhexidine acetate (chlorhexidine acetate is not added in the comparative example) and the esterification agent in the amounts in Examples 1-14 and the comparative example (indicated by 1′) in Table 1 were stirred and dissolved in a soluble amount In the solvent, slowly add hydroxypropyl cellulose under stirring to completely dissolve / swell, continue stirring to form a uniform gel; then add cross-linking agent (add enhancer if necessary), continue stirring to make it completely uniform ; Supplement the remaining amount of solvent to reach the prescription amount, stir evenly, and degas, respectively prepare 100 grams of a chlorhexidine acetate partial film-forming gel composition and a control film-forming gel composition without chlorhexidine acetate.

[0039] Table 1

[0040] Real

[0041] 4

[0042] The experimental results show that the chlorhexidine acetate partial film...

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Abstract

The present invention discloses a compound of an chlorhexidine acetate local membrane forming gel, which comprises the components of the following weight percentages comprising 0.5 percentage to 7 percentage of alkyl cellulose, 1 percentage to 10 percentage of etherifying agent, 0.5 percentage to 5 percentage of cross linking agent,75 percentage to 90 percentage of dissolvent, 0.01 percentage to 3 percentage of chlorhexidine acetate. The cross linking agent is the saturated fat or the alcoholic acid, the chemical general formula of which is CnH2n+2-m-l(OH)m(COOH)l. Among the formula, m or n or 1 is the integer and the n is no less than m, which is no less than 2. 1 is no less than 0 and the result of m plus 1 is 4 to 8. The result of n plus 1 is 4 to 8. In the present invention, the compound of the chlorhexidine acetate local membrane forming gel is applied in the treatment of the local infection in the mucosa or the skin. A water drain protective membrane with smooth property, firm property, wear-resisting property and duration property is formed on the surface of the ulcer when the present invention is applied. Compared with all kinds of local formulation of the chlorhexidine acetate, the membrane formed by the gel compound is not likely to experience fracture, dissolution or corrosion. The membrane has properties of long maintenance time and slow releasing of the medicine. The membrane can be effectively maintained in the skin surface for over 8 hours and the membrane can be effectively maintained on the mouth mucosa surface for over 5 hours.

Description

Technical field [0001] The invention relates to a local film-forming gel composition of chlorhexidine acetate and its application in the treatment of skin / mucosal local infectious diseases. Background technique [0002] Chlorhexidine Acetate (Chlorhexidine Acetate) is a kind of biguanide compound, also known as chlorhexidine acetate (Tai), chlorhexidine acetate, chlorphenidine acetate, etc. It belongs to disinfection, sterilization and antiseptic. It has a bactericidal effect by changing the permeability of the cytoplasmic membrane of the bacteria to leak out the cell contents, and it has a bactericidal effect against Staphylococcus cutaneous, Streptococcus mutans, Streptococcus salivarius, Escherichia coli, Propionibacterium and Candida albicans, etc. All have antibacterial activity. Common topical preparations of chlorhexidine acetate include solutions, gels, ointments and sprays. However, when chlorhexidine acetate in the above dosage form is used for local sterilization, due ...

Claims

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Application Information

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IPC IPC(8): A61K31/155A61K9/00A61K9/70A61K47/10A61K47/12A61K47/38A61P17/00A61P31/04
Inventor 马晋隆陈志明
Owner SHANGHAI INST OF PHARMA IND
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