Method for preparing magnetic silica medicine-carried microball in cotton seed oil by microemulsion liquid method
A technology of silica and microemulsion method, which is applied in the direction of pharmaceutical formulations and medical preparations of non-active ingredients, etc., can solve problems such as unstable existence, and achieve uniform distribution, good biocompatibility, and strong magnetic response Effect
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Embodiment 1
[0024] (1) Mix 0.5 mL of absolute ethanol and 1 mL of deionized water at room temperature to obtain a clear solution;
[0025] (2) Add 0.0009 g of ferric oxide and 300 μL of purpurin-18 drug solution (15 mM concentration) to the solution in step (1), stir for 15 minutes, then add 10 μL of cross-linking agent MPS, and sonicate for 15 minutes ;
[0026] (3) Add 1 mL of ammonia water to the system of step (2), then place the entire reaction system in 15 mL of cottonseed oil, and stir for 1 hour after ultrasonication for 15 minutes;
[0027] (4) Add 10 μL of tetraethyl orthosilicate to the solution in step (3), and stir for 20 hours to obtain a sample;
[0028] (5) The sample solution was centrifuged with a centrifuge, separated and washed with petroleum ether, then washed with absolute ethanol, and vacuum-dried to obtain magnetic silica drug-loaded microsphere nanoparticles. The transmission electron microscope photo is shown in Figure 2, and the ultraviolet spectrum of the RNO...
Embodiment 2
[0030] (1) Mix 0.5 mL of absolute ethanol and 1 mL of deionized water at room temperature to obtain a clear solution;
[0031] (2) Add 160 μL of ferric oxide aqueous solution (containing 0.0009 g of ferric oxide) and 500 μL of purpurin-18 drug solution (concentration: 15 mM) to the solution in step (1), stir for 15 minutes, and then add Combined agent MPS 10μL, sonicate for 15 minutes;
[0032] (3) Add 1 mL of ammonia water to the system of step (2), then place the entire reaction system in 20 mL of cottonseed oil, and stir for 1 hour after ultrasonication for 15 minutes;
[0033] (4) Add 10 μL of tetraethyl orthosilicate to the solution in step (3), and stir for 20 hours to obtain a sample;
[0034] (5) The sample solution was centrifuged with a centrifuge, separated and washed with petroleum ether, then washed with absolute ethanol, and vacuum-dried to obtain magnetic silica drug-loaded microsphere nanoparticles.
Embodiment 3
[0036] (1) Mix 0.5 mL of absolute ethanol and 1 mL of deionized water at room temperature to obtain a clear solution;
[0037] (2) Add 160 μL of ferric oxide aqueous solution (containing 0.0009 g of ferric oxide) and 200 μL of purpurin-18 drug solution (concentration: 30 mM) to the solution in step (1), stir for 15 minutes, and then add Combined agent MPS 10μL, sonicate for 15 minutes;
[0038] (3) Add 1 mL of ammonia water to the system of step (2), then place the entire reaction system in 20 mL of cottonseed oil, and stir for 1 hour after ultrasonication for 15 minutes;
[0039] (4) Add 10 μL of tetraethyl orthosilicate to the solution in step (3), and stir for 20 hours to obtain a sample;
[0040] (5) The sample solution was centrifuged with a centrifuge, separated and washed with petroleum ether, then washed with absolute ethanol, and vacuum-dried to obtain magnetic silicon dioxide drug-loaded microsphere nanoparticles.
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