Eplerenone pharmaceutical composition

A technology of eplerenone and a composition, applied in the field of antihypertensive pharmaceutical compositions, can solve the problems of not specifically disclosing eplerenone surfactant and its dosage, increasing insoluble drugs, complicated preparation process, etc., Achieve the effect of being suitable for large-scale production, improving bioavailability and simple preparation method
CN101152187AInactive Publication Date: 2008-04-02BEIJING D VENTUREPHARM TECH DEV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BEIJING D VENTUREPHARM TECH DEV
Publication Date
2008-04-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a drug combination containing eplerenone. The combination also contains nonionic surface active agent, has high bioavailability, and is used to treat cardiovascular diseases including hypertension.
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Description

technical field

[0001] The invention relates to an antihypertensive pharmaceutical composition, in particular to a pharmaceutical composition containing eplerenone. Background technique

[0002] Eplerenone is a selective aldosterone inhibitor (SAB) that specifically inhibits the function of the hormone aldosterone. Aldosterone is an important component of the renin-angiotensin-aldosterone system (RAAS), which plays an important role in regulating the function of the human cardiovascular system. Its chemical structure is as follows:

[0003]

[0004] Eplerenone can effectively control high blood pressure, reduce damage to target organs such as the heart, brain and kidney, and improve microalbuminuria in patients with type 2 diabetes. The incidence of side effects is similar to that of placebo, and it is well tolerated. It is of great significance for the control of hypertension in hypertensive patients, the prevention of cardiovascular diseases related to target organ dam...

Claims

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