Degradable stephanoporate magnesium basis complex tissue project bracket stuff within biosome

A scaffold material and composite tissue technology, applied in prosthetics, medical science, etc., to achieve good biocompatibility and mechanical properties, enhance self-healing ability, and accelerate the effect of speed

Active Publication Date: 2008-04-09
CHANGSHU MICROTUBE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The invention aims at the deficiencies of existing traditional scaffold materials, and provides a biodegradable porous magnesium-based composite tissue engineering scaffold material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Select particle size to be 200-300 purpose pure magnesium powder (purity ≥ 99.99%), volume content 70%; HA powder (analytical pure) of particle size<80 μm, volume content 10%; Urea powder (analysis pure), volume content 20% %. A porous magnesium bone tissue engineering scaffold with a porosity of about 20% is obtained by powder metallurgy and sintering technology. The pores of the material remain circular or approximately elliptical, most of the pores are connected and distributed, and the size of the pores is about 100 μm-200 μm. The compressive yield strength is about 28MPa, and it can be degraded and absorbed in biological fluid or blood environment, and the degradation rate is about 0.14 mg / month.

Embodiment 2

[0016] Select the high-purity Mg-Zn-Ca alloy powder (purity ≥ 99.99%) of particle size to be 200-300 purpose for use, volume content 60%; HA powder (analytical pure) of particle size<80 μm, volume content 10%; Urea powder (analysis Pure), volume content 30%. A porous magnesium bone tissue engineering scaffold with a porosity of about 30% is obtained by powder metallurgy and sintering technology. The shape of the pores of the material is good, maintaining a circular or approximately elliptical shape, most of the pores are connected and distributed, and the pore size is about 150 μm-300 μm. The compressive yield strength is about 19.5MPa, and it can be degraded and absorbed in biological fluid or blood environment, and the degradation rate is about 0.22 mg / month.

Embodiment 3

[0018] Adopt high-purity Mg-Mn alloy powder (purity ≥ 99.99%) with a particle size of 200-300, with a volume content of 50%; HA powder (analytical pure) with a particle size of <80 μm, with a volume content of 15%; urea powder (analytical pure), with a volume content of Content 35%. A porous magnesium bone tissue engineering scaffold with a porosity of about 35% is obtained by powder metallurgy and sintering technology. The pores of the material remain circular or approximately elliptical, most of the pores are connected and distributed, and the size of the pores is about 150 μm-400 μm. The compressive yield strength is about 16.2MPa, and it can be degraded and absorbed in biological fluid or blood environment, and the degradation rate is about 0.25 mg / month.

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PUM

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Abstract

The invention relates to porous magnesium matrix composite tissue engineering scaffold biomaterial which can degrade in the bio-body. The components and the volume percent contents are 70 percent to 20 percent of high purity magnesium and magnesium alloy powder, 10 percent to 20 percent of HA powder and 20 percent to 70 percent of pore forming agent, the high purity magnesium and the magnesium alloy powder are HA alloys, high purity magnesium alloys, high purity Mg-Zn alloys, high purity Mg-Zn-Ca alloys, high purity Mg-Zn-Ca-Fe alloys, high purity Mg-Mn alloys and high purity Mg-Zn-Mn alloys, and the purity rate of the alloy is higher than or equal to 99.99 percent. The bone tissue engineering scaffold biomaterial prepared by the invention which adopts the powder metallurgy technology utilizes the chemical reaction of the magnesium in aqueous medium to be converted into magnesium ions, and the magnesium ions adjust the balance through the in vivo absorption and the kidney metabolism, thereby leading the scaffold to be gradually degraded and absorbed in vivo.

Description

technical field [0001] The invention relates to a porous magnesium-based composite material in the field of tissue engineering, specifically, a biodegradable porous magnesium-based composite tissue engineering scaffold material. Background technique [0002] Tissue engineering is the application of a small amount of tissue cells that are cultured and expanded in vitro, adsorbed onto a biocompatible biomaterial (scaffold) that can be degraded by the body, and then inoculated into the body to form new tissues with vitality and related functions. organization. Bone tissue engineering is one of them, and its biggest advantage is the formation of living tissue with vitality. A small amount of tissue can be used to repair a large number of tissue defects and can be shaped according to the prefabricated shape, which provides new thinking and new methods for the repair of tissue defects. Ideal bone and cartilage tissue engineering scaffold materials or cell carriers should hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/56A61L27/58
Inventor 李佳楠赵常利张小农
Owner CHANGSHU MICROTUBE TECH
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