Novel process for synthesizing povidone iodine by gas phase/ solid phase reaction

Abstract

The present invention discloses a novel process for synthesizing povidone iodine by gas phase and solid phase reaction. The process combines the iodine-subliming purification process and the synthesization process of povidone iodine by using periston and coarse iodine as raw materials, using a gas phase-solid phase reactor for synthesizing povidone iodine, heating the coarse iodine in the iodine sublimation kettle to make it to sublime to be purified, leading the iodine steam through the heat-preserving conduit into the gas phase-solid phase reactor containing the solid periston to perform gas phase and solid phase reaction directly; adding inert gases with a certain velocity of flow and volume of flow in iodine sublimation kettle to take and raise the flow of the iodine steam in to the gas phase-solid phase reactor; controlling gas phase-solid phase reactor to rotate clockwise and counter-clockwise in a predetermined cycle, and keeping a certain reaction temperature to make periston and iodine stream to be contacted, adsorbed and reacted adequately; exhausting after treatment of the exhaust gas which is connected to the collecting pot of the exhaust gas by the exhaust pipe; batching off when reacting the schedule time to obtain the povidone iodine meeting the pharmacopoeia standard.

Description

Technical field [0001] The invention discloses a new process method for synthesizing povidone-iodine by gas phase / solid phase reaction. Background technique [0002] Povidone-iodine (chemical name is polyvinylpyrrolidone-iodine complex) is a high-efficiency broad-spectrum disinfection and antiseptic drug, in which the iodine atom and polyvinylpyrrolidone are stabilized by complexation, and its basic medicinal principle is The released iodine atoms interact with the proteins of bacteria, fungi and viruses to denature and die, thus playing a role in sterilization and disinfection. Due to the good water solubility of povidone iodine, water-based disinfectants can be prepared. Compared with iodine tincture, povidone iodine is characterized by little irritation to wound tissue. Moreover, due to the gradual and continuous release of iodine atoms during use, it plays the role of disinfection, antibacterial and antiseptic, and can maintain a longer effective disinfection time. [...

AI Technical Summary

Problems solved by technology

Because polyvinylpyrrolidone and medical-grade iodine are directly mixed and heated by the solid-state reaction method, the production process is simple and the post-processing is easy. It is the main production method at present. The disadvantage is that expensive medical-grade granular iodine is used as Raw materials have higher requirements on the purity and particle size uniformity of refined iodine, so the cost of iodine raw materials is higher

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