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Medicinal preparation for percutaneous absorption

A preparation and patch technology, which is applied in the field of percutaneous absorption preparations, can solve the problems of not being able to improve the content stability of ketotifen and inhibit yellowing, and achieve the goal of improving transdermal absorption and content stability, and inhibiting yellowing Effect

Inactive Publication Date: 2008-04-23
SENJU PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But for the patch that contains ketotifen fumarate as an active ingredient, even if such packaging material is used for packaging, the content stability of ketotifen cannot be improved, and yellowing cannot be inhibited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Among the components shown in Table 1, SIS-based adhesive base: Quintuck 3570C (manufactured by Nippon Zeon Co., Ltd.), rosin ester-based tackifier resin: Pink Crystal KE311 (manufactured by Arakawa Chemical Industry Co., Ltd.) and iso-palmitic acid The propyl ester was dissolved in toluene, and ketotifen fumarate and Tris were added to the solution to obtain an adhesive. This adhesive was coated on a silicon-treated PET film having a thickness of 75 μm so that the thickness after drying was 40 μm, and dried at 110° C. for 3 minutes to form an adhesive layer. Next, a PET film with a thickness of 25 μm was laminated on the adhesive layer. The patch obtained in this way was packaged in a hygroscopic packaging material (Toyaldray (trade name), manufactured by Toyo Arminium Co., Ltd.) to obtain the percutaneous absorption preparation of the present invention.

Embodiment 2

[0055] The percutaneous absorption preparation of the present invention was obtained in the same manner as in Example 1, except that the atmosphere in the packaging material was replaced with nitrogen (substitution rate of 70% or more).

Embodiment 3

[0057] Except that a 10% propyl gallate solution (methanol / toluene=1 / 9) was further added to the adhesive, the same procedure as in Example 1 was carried out to obtain the percutaneous absorption preparation of the present invention.

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Abstract

The invention provides a medicinal preparation for percutaneous absorption characterized by comprising a hygroscopic packaging material and, packed therein, a pressure-sensitive adhesive patch which comprises a substrate and formed thereon a pressure-sensitive adhesive layer and in which the pressure-sensitive adhesive layer contains ketotifen fumarate and tris(hydroxymethyl)aminomethane. The medicinal preparation for percutaneous absorption contains tris(hydroxymethyl)aminomethane, which was especially selected among many basic substances, and this substance has been packed in a hygroscopic packaging material. Due to this, percutaneous drug absorbability and drug content stability can be simultaneously improved and yellowing can be inhibited. These effects can be further improved by adding propyl gallate, by using a pressure-sensitive adhesive layer comprising an SIS type pressure-sensitive adhesive base and a rosin ester tackifier resin, and / or by removing oxygen from the atmosphere in the packing material.

Description

technical field [0001] The invention relates to a transdermal absorption preparation, which contains Ketotifen fumarate as an active ingredient. The active ingredient has good transdermal absorption, the drug content in the preparation is stable over time, and yellowing can be suppressed. In further detail, the present invention relates to a transdermal absorption preparation in a patch formed by providing an adhesive layer on a support, and the adhesive layer contains fumaric acid In addition to ketotifen, a specific alkaline substance is contained, and the patch is packaged in a hygroscopic packaging material. Background technique [0002] 4-(1-methyl-4-piperidinylene)-4H-benzo[4,5]cycloheptane[1,2-b]thiophene-10(9H)-one (hereinafter referred to as keto Fen.) and its salts have a wide range of antiallergic and antihistamine effects, and are known to be effective for bronchial asthma, allergic rhinitis, eczema, dermatitis, urticaria, pruritus, and eye diseases. [0003] I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4535A61K9/70A61K47/14A61K47/16
CPCA61K47/14A61K9/7053A61K31/4535A61K9/7076A61P11/00A61P11/02A61P11/06A61P17/00A61P17/04A61P27/14A61P37/08A61K9/70
Inventor 川原康慈新籾康彦岛田纪子大鸟聪礒胁明治
Owner SENJU PHARMA CO LTD
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