Method for preparing capsaicin microcapsule

A technology for capsaicin and microcapsules is applied in the field of preparing capsaicin microcapsules, which can solve the problems of low drug loading and encapsulation efficiency, complicated operation, low capsule wall strength and the like, and achieves high drug loading and encapsulation efficiency. Overcome the tedious operation and improve the effect of the use environment

Inactive Publication Date: 2012-05-30
SHANGHAI CHEM REAGENT RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the invention: to provide a preparation method of capsaicin microcapsules to overcome the shortcomings of the preparation methods in the prior art, such as cumbersome operation, low drug loading and encapsulation efficiency, and low capsule wall strength

Method used

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  • Method for preparing capsaicin microcapsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Preparation of melamine-formaldehyde resin prepolymer

[0024] Add 189.2g (1.5mol) melamine solid and 243.2g (3.0mol) 37wt% formaldehyde aqueous solution in the 500ml reaction bottle with heater, stirrer, thermometer, under stirring, adjust pH with 10wt% sodium hydroxide aqueous solution to be 8, Heat to raise the temperature, and react at 70±5°C for 1.5 hours. Finally, 300 ml of water was added at room temperature for dilution, and 740.6 g of melamine-formaldehyde resin prepolymer was prepared.

[0025] (2) Preparation of capsaicin emulsion

[0026] Weigh 50g of capsaicin and dissolve it in 100ml of ethyl acetate, weigh 2.0g of gum arabic powder, 2.0g of Tween-80, 0.5g of sodium polyacrylate, and 1.0g of polyvinyl alcohol and dissolve it in 110ml of water, mix the two phases, Use FA25-18G high-shear dispersing emulsifier (produced by Shanghai FLUKO Fluid Machinery Manufacturing Co., Ltd.) to emulsify for 40 minutes at room temperature to obtain 246.0 g of capsaic...

Embodiment 2

[0030] (1) Preparation of melamine-formaldehyde resin prepolymer

[0031] Add 126.1g (1.0mol) melamine solid and 150g (2.0mol) 25% formaldehyde aqueous solution in the 500ml reaction bottle with heater, stirrer, thermometer, adjust pH to be 8 with 10% sodium hydroxide aqueous solution under stirring, heat Raise the temperature and react at 70±5°C for 1.5 hours. Finally, 200 ml of water was added at room temperature for dilution to obtain 479.0 g of melamine-formaldehyde resin prepolymer.

[0032] (2) Preparation of capsaicin emulsion

[0033] Weigh 50g capsaicin and dissolve in 100ml ethyl acetate, weigh 2.0g gum arabic powder, 2.0g Tween-80, 0.5g styrene-maleic anhydride copolymer (SMA), 1.0g polyvinyl alcohol and dissolve In 120ml of water, the two phases were mixed, and emulsified at room temperature for 30 minutes with a high-shear emulsifier (FA25-18G), to obtain 255.6g of capsaicin emulsion.

[0034] (3) preparation of capsaicin microcapsules

[0035] Mix the capsaic...

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Abstract

The invention discloses a preparation method of capsaicin micro capsule. The invention method takes trimeric cyanamide as the raw material, which is reacted with formalin solution under the alkalinity condition, so as to obtain the performed polymer of trimeric cyanamide-metahanal resin; the organic solution of the capsaicin is emulsified with emulsifying agent composed of surface active agent toobtain capsaicin emulsion fluid; the performed polymer of trimeric cyanamide-metahanal resin is taken as the wall material, the capsaicin emulsion fluid is taken as the core material, and in-situ polymerization is performed under the acidic condition to prepare the capsaicin micro capsule. The yield rate of the capsaicin micro capsule obtained in the preparation method of the invention is more than 86.9 to 90.2 percent, the drug loading quantity is about 18.4 to 24.7 percent, and the package rate is about 88.5 to 94.3 percent. Compared with the prior technology, the capsaicin micro capsule obtained in the preparation method of the invention has the following advantages: the strong excitability produced during the use is avoided, the using environment is greatly improved, the invention accords to the green and environmental protection requirements, the reaction process is secure and simple, the drug loading quantity and the package rate are high, and the invention is suitable for the industrialized production.

Description

technical field [0001] The invention relates to a method for preparing capsaicin microcapsules. Background technique [0002] The main component of capsaicin is N-vanillyl nonanamide. With its special pungent taste, it is widely used in ship antifouling coatings, to prevent postharvest diseases of fruits and vegetables, and to protect wires, cables, communication equipment, and packaging materials from being bitten by rats. Damaged, grains are lost to birds. The structural formula of capsaicin is as follows: [0003] [0004] In order not to change the original performance of capsaicin, it is convenient to use, and the method of microcapsules is often used for coating. The principle of the microcapsule method is to use the polymerization reaction of small monomer molecules to form a polymer film-forming material. The capsule core wraps the substance to be coated in microcapsules of several microns to hundreds of microns. The commonly used preparation methods include int...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C233/55B01J13/02
Inventor 何扣宝施险峰
Owner SHANGHAI CHEM REAGENT RES INST
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