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Method for preparing alcohol extract of tibetan medicine Qing-peng slurry

A technology of Qingpeng ointment and ointment, which is applied in the direction of medical formulas, medical preparations containing active ingredients, antipyretics, etc. It can solve problems such as unstable sources of raw materials and excipients, affecting product efficacy and promotion, and difficulty in exerting drug efficacy. , to achieve the effect of improving bioavailability, solving the problem of transdermal absorption, and simple and easy production process

Active Publication Date: 2008-05-21
GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The preparation process of the traditional Tibetan medicine Qingpeng ointment is to mix all the original medicinal materials into an ointment. The process is complicated, the batch production cycle is long, and the production process is unstable; the source of raw materials and excipients is unstable, which is not conducive to industrial production; some drugs penetrate The ability is poor, the bioavailability is low, the curative effect cannot be fully guaranteed, and it is not easy to exert the curative effect of the drug; in addition, the product is not easy to store and is inconvenient to carry; due to various reasons, the curative effect and promotion of the product are greatly affected

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] Raw materials: Oxytropis 11g, subrhubarb 4g, iron stick hammer 8g, myrobalan 11g, myrobalan 11g, emblica 11g, benzoin 2g, vine vine 18g, musk 1g.

[0104] Preparation Process:

[0105] ①Pure Oxytropis, subrhubarb, iron rod hammer, myrobalan, myrobalan, emblica, benzoin, and broad tendon rattan, grind them, mix them evenly, and set aside;

[0106]② Weigh 10% of the total weight of the mixed medicinal powder, extract 4 times with 30% ethanol, add alcohol 5 times the total weight of the medicinal materials each time, at a temperature of 95°C, for 3 hours each time, combine the extracts, filter, and concentrate Concentrated solution with a specific gravity of 1.3 for subsequent use;

[0107] ③After pulverizing the remaining medicinal powder (90%) into medicinal powder of 0.01~200 μm, mix with the above-mentioned concentrated medicinal liquid, 56g polysorbate-80, 320g glycerol, stir evenly, obtain the mixed liquid of medicinal liquid and water phase, heat up to Standby at ...

Embodiment 2

[0110] Raw materials: Oxytropis 16g, subrhubarb 9g, iron rod hammer 13g, myrobalan 16g, myrobalan 16g, emblical 16g, benzoin 7g, vine vine 23g, artificial musk 6g.

[0111] Preparation Process:

[0112] ①Pure Oxytropis, subrhubarb, iron rod hammer, myrobalan, myrobalan, emblica, benzoin, and broad tendon rattan, grind them, mix them evenly, and set aside;

[0113] ②Weigh 15% of the total weight of the mixed medicinal powder, extract 3 times with 70% ethanol, add alcohol 10 times the total weight of the medicinal materials each time, and keep the temperature at 70°C for 2 hours each time, combine the extracts, filter, and concentrate A concentrated solution with a specific gravity of 1.1 is used for later use.

[0114] ③ After crushing the remaining medicinal powder (85%) above into 0.01-200μ medicinal powder, mix it with concentrated solution, 370g cetyl alcohol, and 480g propylene glycol, and stir evenly to obtain a mixed liquid of medicinal liquid and water phase, heat up t...

Embodiment 3

[0117] Raw materials: Oxytropis 13.5g, subrhubarb 6.5g, iron rod hammer 10.5g, myrobalan 13.5g, myrobalan 13.5g, emblical 13.5g, benzoin 4.5g, vine vine 20.5g, musk 3.5g.

[0118] Preparation Process:

[0119] ①Pure Oxytropis, subrhubarb, iron rod hammer, myrobalan, myrobalan, emblical, benzoin, and broad tendon rattan, grind them, mix them evenly, and set aside;

[0120] ② Weigh 30% of the total weight of the mixed medicinal powder, extract twice with 85% ethanol, add alcohol 15 times of the total weight of the medicinal materials each time, at a temperature of 60°C, for 1 hour each time, combine the extracts, filter, and concentrate A concentrated solution with a specific gravity of 1.2 is used for subsequent use.

[0121] ③ Grind the remaining medicinal powder (70%) into 0.01-200 μm medicinal powder, mix with concentrated medicinal liquid, 45g glyceryl stearate, 120g water, and 80g glycerin, stir evenly to obtain a mixed liquid of medicinal liquid and water phase, heat up ...

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PUM

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Abstract

The invention provides a novel preparation method for Tibetan medicine Qingpeng ointment. The invention is made through a modern advanced technology based on the original formula of the Tibetan medicine Qingpeng ointment, thereby not only effectively remaining the active materials and the effective components in the medicine materials, but also greatly increasing the dissolution rate of the fresh medicine components, and at the same time increasing the bioavailability and effectively increasing the cure efficiency, as well as overcoming the shortcomings of the traditional Qingpeng ointment. The product prepared by the invention has no odor, good stability, and convenient use, carrying and storing. The invention has the advantages of simple technology, easy operation, stable raw material and assistant material source, and easy industrialization.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a preparation method of Qingpeng ointment, in particular to a new preparation method of Qingpeng ointment made by modern advanced technology based on the formula of traditional Tibetan medicine Qingpeng ointment . Background technique [0002] Qingpeng ointment is a classic Tibetan medicine prescription composed of Tibetan folk doctors based on the records of "Tibetan Medicine and Supplements" and "Four Medical Codes", combined with practical experience. The prescription is included in the 95th edition of "Drug Standards issued by the Ministry of Health" The first volume of medicine, 322 pages. The prescription of Qingpeng ointment is: [0003] Oxytropis sickle 100g sub-rhubarb 50g iron bar hammer 75g myrobalan 100g mulberry 100g [0004] emblica 100g benzoin 35g wide tendon rattan 150g musk 25g [0005] Preparation method: the above nine flavors, except...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/06A61P19/06A61P29/00A61P31/22A61K31/122A61K35/55
Inventor 雷菊芳张樱山陈丽娟刘海龙贺国杰
Owner GANSU CHEEZHENG TIBETAN MEDICINE CO LTD
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