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Ceramide nano liposome preparations and preparation and application thereof

A ceramide and nano-lipid technology, which is applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of high melting point, low stability and low solubility of ceramides, and achieve stable product quality and formulation. Convenient, small particle size effect

Active Publication Date: 2008-07-09
KARLIE COSMETICS MFG CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, ceramide itself has physical and chemical properties such as high melting point and insoluble properties, especially its low solubility in oil and easy crystallization, which has a great impact on the cosmetics production process and product quality.
[0004] Patent CN1223112 provides a preparation method of ceramide liposome emulsion, which has large particle size and low stability; patent CN1602181 provides a kind of ceramide emulsion. The substance is emulsified to form a large particle size, white ceramide emulsion; patent CN101049280 provides a cosmetic composition and method including at least one hydroxy acid, at least one monosaccharide or disaccharide and at least one ceramide

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Example 1 Weigh 0.1% ceramide IIIA, 0.1% soybean lecithin and 0.1% ethanol and stir at 60°C to form a transparent solution, then add 70% glycerin and 29.7% deionized water to the mixture and stir to form a uniform mixture liquid, and then the mixed solution was circulated through a high-pressure homogenizer for 8 times under the pressure of 100 bar, and finally the ethanol was removed by conventional vacuum distillation to obtain a transparent ceramide nanoliposome preparation. The ceramide nanoliposome preparation The particle size is about 28nm as measured by a laser particle size analyzer.

Embodiment 2

[0053] Example 2 Weigh 2.5% ceramide IIIA, 10% egg yolk lecithin, and 3% ethanol and stir at 70°C to form a transparent solution, then add 50% glycerin and 34.5% deionized water to the mixture and stir to form a uniform mixed solution, and then the mixed solution was processed through a high-pressure homogenizer cycle for 4 times under the pressure condition of 500 bar, and finally the ethanol was removed through conventional vacuum distillation to obtain a translucent ceramide nanoliposome preparation, the ceramide nanolipid The particle size of the body preparation is about 49nm as measured by a laser particle size analyzer.

Embodiment 3

[0054] Example 3 Weigh 5% ceramide II, 10% soybean lecithin, 10% egg yolk lecithin, 2% polyethylene glycol caprylic acid / capric glyceride and 5% ethanol and stir at 80°C to form a transparent solution, and then add to Add 10% glycerin and 58% deionized water to the mixed solution and stir to form a uniform viscous mixed solution, then the mixed solution is processed by a high-pressure homogenizer cycle for 4 times under the pressure of 800bar, and finally removed by conventional vacuum distillation The transparent ceramide nanoliposome preparation was obtained by ethanol, and the particle size of the ceramide nanoliposome preparation was measured by a laser particle size analyzer to be about 53 nm.

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Abstract

The present invention provides ceramide nanometer lipidosome preparation, a preparation method and application thereof and concretely relates to the ceramide nanometer lipidosome preparation, the preparation method and the application thereof. The present invention is characterized by mixing and emulsifying the ceramide with the weight percentage of 0.1 percent to 5 percent, 1 percent to 20 percent of phospholipid, 10 percent to 70 percent of glycerin, 25 percent to 80 percent of water etc. orderly and uniformly under the temperature condition of 60 DEG C to 80 DEG C. Finally, a high pressure viscolizer is used for processing the materials to obtain the transparent or semitransparent ceramide nanometer lipidosome preparation with average grain size less than 100nm. The ceramide nanometer lipidosome preparation has the characteristics of high stability, water dispersibility, biological compatibility etc., which can be widely applied to the cosmetic preparation technical field.

Description

technical field [0001] The invention relates to a ceramide nano liposome preparation, which belongs to the technical field of cosmetics. Background technique [0002] Ceramide is a kind of phospholipid with ceramide as the skeleton, and mainly exists in the cell membrane and intercellular matrix in the stratum corneum. Clinical studies have shown that the lipids in the stratum corneum of the human body contain about 50% ceramide, and the content of ceramide in the human body decreases with age, especially in the face and hands. Regular supplementation of ceramide can repair the skin barrier function, and has strong moisturizing, anti-aging and whitening effects. [0003] However, ceramide itself has physical and chemical properties such as high melting point and insoluble properties, especially its low solubility in oil and easy crystallization, which has a great impact on the cosmetics production process and product quality. [0004] Patent CN1223112 provides a preparatio...

Claims

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Application Information

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IPC IPC(8): A61K8/42A61K8/14A61Q19/00
Inventor 周华锋段明星郑昌学陈斌严泽民
Owner KARLIE COSMETICS MFG CO LTD
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