Ceramide nano liposome preparations and preparation and application thereof

A ceramide and nano-lipid technology, which is applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve the problems of high melting point, low stability and low solubility of ceramides, and achieve stable product quality and formulation. Convenient, small particle size effect

Active Publication Date: 2008-07-09
KARLIE COSMETICS MFG CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, ceramide itself has physical and chemical properties such as high melting point and insoluble properties, especially its low solubility in oil and easy crystallization, which has a great impact on the cosmetics production process and product quality.
[0004] Patent CN1223112 provides a preparation method of ceramide liposome emulsion, whi

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0052] Example 1 Weigh 0.1% ceramide IIIA, 0.1% soy lecithin and 0.1% ethanol at 60°C and stir to form a transparent solution, then add 70% glycerin and 29.7% deionized water to the mixture and stir to form a uniform mixture Then, the mixture is processed by a high-pressure homogenizer for 8 cycles under a pressure of 100bar, and finally the ethanol is removed by conventional vacuum distillation to obtain a transparent ceramide nanoliposome preparation. The ceramide nanoliposome preparation The particle size is about 28nm measured by laser particle size analyzer.

Example Embodiment

[0053] Example 2 Weigh 2.5% ceramide IIIA, 10% egg yolk lecithin, and 3% ethanol at 70°C and stir to form a transparent solution, and then add 50% glycerin and 34.5% deionized water to the mixture and stir to form a uniform The mixed solution is processed by a high-pressure homogenizer for 4 times under the condition of 500bar pressure, and finally the ethanol is removed by conventional vacuum distillation to obtain a translucent ceramide nanoliposome preparation. The ceramide nanolipid The size of the body preparation is about 49nm measured by a laser particle size analyzer.

Example Embodiment

[0054] Example 3 Weigh 5% ceramide II, 10% soybean lecithin, 10% egg yolk lecithin, 2% polyethylene glycol caprylic acid / capric glyceride and 5% ethanol at 80°C and stir to form a transparent solution, and then Add 10% glycerin and 58% deionized water to the mixture and stir to form a uniform viscous mixture. Then the mixture is processed by a high-pressure homogenizer under 800bar pressure for 4 cycles, and finally removed by conventional vacuum distillation. Ethanol obtains a transparent ceramide nanoliposome preparation, and the particle size of the ceramide nanoliposome preparation is determined by a laser particle sizer to be about 53 nm.

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Abstract

The present invention provides ceramide nanometer lipidosome preparation, a preparation method and application thereof and concretely relates to the ceramide nanometer lipidosome preparation, the preparation method and the application thereof. The present invention is characterized by mixing and emulsifying the ceramide with the weight percentage of 0.1 percent to 5 percent, 1 percent to 20 percent of phospholipid, 10 percent to 70 percent of glycerin, 25 percent to 80 percent of water etc. orderly and uniformly under the temperature condition of 60 DEG C to 80 DEG C. Finally, a high pressure viscolizer is used for processing the materials to obtain the transparent or semitransparent ceramide nanometer lipidosome preparation with average grain size less than 100nm. The ceramide nanometer lipidosome preparation has the characteristics of high stability, water dispersibility, biological compatibility etc., which can be widely applied to the cosmetic preparation technical field.

Description

technical field [0001] The invention relates to a ceramide nano liposome preparation, which belongs to the technical field of cosmetics. Background technique [0002] Ceramide is a kind of phospholipid with ceramide as the skeleton, and mainly exists in the cell membrane and intercellular matrix in the stratum corneum. Clinical studies have shown that the lipids in the stratum corneum of the human body contain about 50% ceramide, and the content of ceramide in the human body decreases with age, especially in the face and hands. Regular supplementation of ceramide can repair the skin barrier function, and has strong moisturizing, anti-aging and whitening effects. [0003] However, ceramide itself has physical and chemical properties such as high melting point and insoluble properties, especially its low solubility in oil and easy crystallization, which has a great impact on the cosmetics production process and product quality. [0004] Patent CN1223112 provides a preparatio...

Claims

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Application Information

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IPC IPC(8): A61K8/42A61K8/14A61Q19/00
Inventor 周华锋段明星郑昌学陈斌严泽民
Owner KARLIE COSMETICS MFG CO LTD
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