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Preparation method of calcium glycine

A technology of calcium glycinate and glycine, which is applied to the preparation of organic compounds, chemical instruments and methods, and preparation of cyanide reactions, etc., can solve the problems of limiting the application of calcium glycinate, uneven product quality, and different effects, and is easy to promote , stable product quality and simple preparation process

Inactive Publication Date: 2008-07-23
洪作鹏
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, due to process design and route problems, the product quality is uneven and the effect is different. At the same time, due to the lack of standard calcium glycinate quality inspection and analysis methods, the product cannot be evaluated objectively, which greatly limits the application of calcium glycinate in food and health products. application in

Method used

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  • Preparation method of calcium glycine

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Embodiment 1

[0016] Embodiment 1: select glycine and calcium chloride as main raw materials, the reaction molar ratio of the two is 2: 1, first glycine is dissolved in water, and solid alkali is added to make it fully react, obtain glycine sodium salt after membrane separation, Dissolve calcium chloride in a solvent and add the aforementioned glycine sodium salt, adjust the pH to 5, heat to 80°C, react under stirring for 3 hours, evaporate and concentrate with a scraper film until the crystal film is deposited on the surface, take it out and store it at room temperature Slowly cool, then place in a refrigerator at 4°C for crystallization for 24 hours, place the purified crystals in a vacuum oven for drying, and make the chemical structural formula: [Ca(C 2 h 5 NO 2 ) 2 · Cl 2 ] of calcium glycinate products.

Embodiment 2

[0017] Embodiment 2: select glycine and calcium chloride as main raw materials, the reaction molar ratio of the two is 1: 1, first glycine is dissolved in water, and solid alkali is added to make it react fully, obtain glycine sodium salt after membrane separation, Dissolve calcium chloride in a solvent and add the above-mentioned glycine sodium salt, adjust the pH to 8, heat to 100°C, react for 4 hours under stirring, evaporate and concentrate with a scraper film until the crystal film is deposited on the surface, take it out and store it at room temperature Cool slowly, and then place it in a refrigerator at 7°C for crystallization for 20 hours, and place the purified crystals in a vacuum oven for drying to produce a calcium glycinate product.

Embodiment 3

[0018] Embodiment 3: select glycine and calcium chloride as main raw materials, the reaction molar ratio of the two is 3: 1, first glycine is dissolved in water, and solid alkali is added to make it react fully, obtain glycine sodium salt after membrane separation, Dissolve calcium chloride in a solvent and add the above-mentioned glycine sodium salt, adjust pH=3, heat to 60°C, react for 1 hour under stirring, evaporate and concentrate with a scraper film until the crystal film is deposited on the surface, take it out and store it at room temperature Cool slowly, and then place it in a refrigerator at 2°C for crystallization for 26 hours, and place the purified crystals in a vacuum oven for drying to produce a calcium glycinate product.

[0019] In the above-mentioned embodiments of the present invention, the calcium chloride and the solvent are mixed in a certain proportion, glycine sodium salt is added, and the pH value is adjusted. After heating and stirring, the mixture is ...

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Abstract

The invention relates to a preparation method of glycine calcium, selecting glycine and calcium chloride as main materials and the molar ratio of glycine and calcium chloride in the range of 1:1 to 3:1 and 1:1-1:3, which is characterized in that: firstly, the glycine is dissolved in water, solid caustic soda is added into the solution to react with the glycine thoroughly and glycine sodium salt is obtained after the membrane separation, and then, the calcium chloride dissolved by a solvent is added into the glycine sodium salt solution, the pH value of the solution with the glycine sodium salt and the calcium chloride is regulated in the range of three to eight, the solution is heated to sixty to one hundred degrees and reacts for one to four hours under agitation, and the solution is evaporated and concentrated by scraper film until the precipitation of crystal membrane on the surface, the precipitated crystal membrane is cooled slowly at the ambient temperature and is crystallized for at least 18 hours at a temperature lower than 8 degrees, at last, after the vacuum drying of the crystallized and purified crystal, the glycine calcium product with a molecular structure form of [Ca(C2H5NO2)2Cl2] is obtained. The preparation method of glycine calcium has the advantages of simple preparation technique, high product quality of the products produced by the preparation method and popularization convenience.

Description

technical field [0001] The invention relates to a preparation method of a preparation product for human calcium supplementation, and the synthesis of calcium glycinate belongs to the complexation technology of amino acid trace elements. Background technique [0002] Calcium plays a pivotal role in human life activities, such as bone formation, heart beating, brain thinking and muscle contraction. Since calcium cannot be synthesized by the human body itself, it needs to be taken in from the outside world, so a person needs to take in calcium from the outside world throughout his life. At present, there are more than 40 kinds of calcium nutritional fortifiers allowed to be used in the world, and they can be summarized into the following three types. One is calcium preparations produced from natural biological raw materials, which mainly include bone meal, eggshell powder, biological calcium carbonate, active calcium, and calcium carbonate. Calcium, etc., but its bioavailabili...

Claims

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Application Information

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IPC IPC(8): C07C229/76C07C229/08C07C227/16
Inventor 洪作鹏
Owner 洪作鹏
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