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Compound digestive enzyme locating release capsule

A technology of digestive enzymes and capsules, which is applied in the digestive system, capsule delivery, pharmaceutical formulations, etc., and can solve problems such as low unit enzyme titer

Inactive Publication Date: 2008-09-24
BEIJING SUNHO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The compound digestive enzyme capsule (Daji) produced by Korea Hanlin Co., Ltd. is of the same type as the enzyme of the present invention, but its unit enzyme titer is lower

Method used

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  • Compound digestive enzyme locating release capsule
  • Compound digestive enzyme locating release capsule
  • Compound digestive enzyme locating release capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0208] The prescription and process of gastric dissolving tablet I released from upper stomach:

[0209] Pepsin 25g Dextrin 50g Starch 120g

[0210] Sodium carboxymethyl cellulose 15g stearic acid enzyme 3g 10% starch slurry appropriate amount

[0211] Stomach dissolving coating powder 12g 75% ethanol appropriate amount

[0212] (1). Dissolve the gastric coating powder in 75% ethanol to make a 20% coating solution;

[0213] (2) Weigh 5g of sodium carboxymethyl starch, mix it with the prescribed amount of dextrin and starch, add 10% starch slurry in batches to make soft material, granulate, dry at 60-70℃, and granulate; Take the prescribed amount of pepsin, the remaining amount of sodium carboxymethyl starch, magnesium stearate and the prepared blank granules and mix them evenly, and press them into 1000 6mm microtablets;

[0214] (3) Place the microtablets in a coating pan and spray the prepared gastric dissolving coating powder ethanol solution to obtain gastric dissolving coated...

Embodiment 2

[0232] The prescription and process of gastric dissolving tablet I released from the upper part of the stomach:

[0233] Pepsin 25g Dextrin 80g Starch 70g

[0234] Sodium carboxymethyl cellulose 10g stearic acid enzyme 1g 15% starch slurry appropriate amount

[0235] Stomach dissolving coating powder 4g 75% ethanol appropriate amount

[0236] (1). Dissolve the gastric coating powder in 75% ethanol to prepare a 5% coating solution;

[0237] (2) Weigh 5g of sodium carboxymethyl starch, mix it with the prescribed amount of dextrin and starch evenly, add 15% starch slurry in batches to make soft material, granulate, dry at 60-70℃, and granulate; Take the prescribed amount of pepsin, the remaining amount of sodium carboxymethyl starch, magnesium stearate and the prepared blank granules and mix them evenly, and compress them into 1000 6mm microtablets;

[0238] (3) Place the microtablets in a coating pan, and spray the prepared gastric dissolving coating powder ethanol solution to obtai...

Embodiment 3

[0256] White tablet prescription and process:

[0257] Pepsin 25g lactose 40g microcrystalline fiber 90g

[0258] c-PVP 5g stearic acid enzyme 2g 5% starch slurry appropriate amount

[0259] Stomach dissolving white coating powder 1.2g 75% ethanol appropriate amount

[0260] (1). Dissolve the stomach-soluble white coating powder in 75% ethanol to prepare a 10% coating solution;

[0261] (2). Weigh the prescription amount of lactose and microcrystalline fiber and mix them evenly, add 10% starch slurry aqueous solution in portions to make soft material, granulate, dry at 60-70℃, and whole; take the prescription amount of pepsin , C-PVP, magnesium stearate and the prepared blank particles are mixed uniformly, and compressed into 1000 pieces of 6mm microtablets;

[0262] (3) Put the microtablets in a coating pan, spray the prepared gastric-dissolved white coating powder with ethanol until the weight gain of the coating is about 2%, and the white gastric-dissolved coated tablets are ob...

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Abstract

The invention relates to a compound digestive enzyme positioning and releasing capsule prescription and a preparation process thereof. The capsule consists of three micro-tablets which respectively release medicine in the upside of the stomach, in the antrum of the stomach, and in the intestines thereof; during preparation, the main medicine and the auxiliary medicine contained in the tablets are pressed into three different tablets, the respective tablets are covered with film coatings released under different pH conditions so as to achieve the purpose of releasing in different sites. Compared with the prior similar products, the compound digestive enzyme preparation of the invention has better positioning and releasing effect, as well as more comprehensive and higher enzyme vigor.

Description

Technical field [0001] The present invention relates to a compound digestive enzyme positioning release capsule tablet preparation. More specifically, the positioning release capsule of the present invention contains three types of tablets released from different positions, namely, pepsin-containing tablets I released in the upper part of the stomach, and released in the antrum of the stomach. Tablet II containing ursodeoxycholic acid, papain, and amylase, and tablet III containing cellulase and pancreatin released in the intestine. Background technique [0002] Commonly used drugs for indigestion are appetite-increasing drugs and digestive aids. Digestive drugs refer to a class of drugs that can promote the digestive process of the gastrointestinal tract. The main component of most digestive drugs is digestive enzymes. When the secretion of the digestive tract is insufficient, they can play an alternative therapy role. At present, the most common types of digestive aids in China...

Claims

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Application Information

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IPC IPC(8): A61K38/48A61K38/47A61K38/46A61K9/48A61K9/28A61K47/36A61K47/38A61P1/14A61K31/575
Inventor 张明张树祥
Owner BEIJING SUNHO PHARMA
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