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Transparent aquagel having antibacterial action and preparation thereof

A technology of antibacterial effect and hydrogel, which is applied in the field of transparent hydrogel and its preparation, can solve problems such as difficult realization, and achieve good biocompatibility, good development prospects, and simple synthesis methods

Inactive Publication Date: 2008-10-08
BIOCHEM ENG COLLEGE OF BEIJING UNION UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some methods are involved, it is difficult for general laboratories or enterprises to implement the radiation body polymerization method.

Method used

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  • Transparent aquagel having antibacterial action and preparation thereof
  • Transparent aquagel having antibacterial action and preparation thereof
  • Transparent aquagel having antibacterial action and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Add 100 parts by weight of acrylic acid and acrylamide into the reactor, start electromagnetic stirring; add NaOH aqueous solution dropwise for neutralization, and the neutralization degree is 75%. Wherein, the concentration of NaOH aqueous solution is 20wt%.

[0056] It should be noted that, in 100 parts by weight of acrylic acid and acrylamide, the weight ratio between acrylic acid and acrylamide is arbitrary. In Example 1, the weight ratio of acrylic acid and acrylamide is 1:1.

[0057] Add 1 part by weight of ammonium persulfate into the reactor, mix uniformly and start the temperature rise reaction, and control the reaction temperature between 50°C and 90°C. The reaction was stopped when the reaction mixture changed from a white turbid gel to a transparent gel. The gel is taken out and dried in an oven to obtain polyacrylic acid and acrylamide-based superabsorbent resin. Infrared spectra of polyacrylic acid and acrylamide superabsorbent resin figure 1 shown.

...

Embodiment 2

[0063] Add 85 parts by weight of acrylic acid, 10 parts by weight of methyl methacrylate, and 5 parts by weight of N,N-methylene bisacrylamide into the reactor, start electromagnetic stirring; add NaOH aqueous solution dropwise for neutralization, neutralization The degree is 75%. Wherein, the concentration of NaOH aqueous solution is 20wt%.

[0064] Add 1 part by weight of ammonium persulfate into the reactor, mix uniformly and start the temperature rise reaction, and control the reaction temperature between 50°C and 90°C. The reaction was stopped when the reaction mixture changed from a white turbid gel to a transparent gel. The gel was taken out and placed in an oven to dry.

[0065] A chitosan aqueous solution with a concentration of 5 wt % is prepared, and 1 wt % cerium ammonium nitrate relative to the chitosan aqueous solution is added at the same time. The weighed dry polyacrylic acid-based superabsorbent resin was immersed in an aqueous chitosan solution with a conc...

Embodiment 3

[0070] Add 85 parts by weight of acrylic acid, 10 parts by weight of hydroxyethyl acrylate, and 5 parts by weight of ethylene glycol diacrylate into the reactor, start electromagnetic stirring; dropwise add NaOH aqueous solution for neutralization, and the degree of neutralization is 75%. Wherein, the concentration of NaOH aqueous solution is 20wt%.

[0071] Add 1 part by weight of ammonium persulfate into the reactor, mix uniformly and start the temperature rise reaction, and control the reaction temperature between 50°C and 90°C. The reaction was stopped when the reaction mixture changed from a white turbid gel to a transparent gel. The gel was taken out and placed in an oven to dry.

[0072] A chitosan aqueous solution with a concentration of 5 wt % is prepared, and 1 wt % cerium ammonium nitrate relative to the chitosan aqueous solution is added at the same time. The weighed dry polyacrylic acid-based superabsorbent resin was immersed in an aqueous chitosan solution with...

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Abstract

Disclosed are an anti-bacterial transparent hydrogel and the preparation method. The hydrogel is a copolymer grafted on polyacrylic acid and / or acrylamide super absorbent resin by chitosan, wherein, the content of chitosan is 3% to 5% of the total weight of the hydrogel. The preparation method comprises the following steps: (1) the polyacrylic acid and / or the acrylamide super absorbent resin are synthesized; (2) ceric ammonium nitrate is dissolved in chitosan aqueous solution; (3) the polyacrylic acid and / or the acrylamide super absorbent resin are submerged into the chitosan solution; (4) at a temperature of 30 to 95 DEG C, the polyacrylic acid and / or the acrylamide super absorbent resin having absorbed the chitosan solution which contains ceric ammonium nitrate are put into an infrared radiation box to initiate polymerization so as to obtain the copolymer; (5) the copolymer is then leached with deionized water and trichloromethane, so as to obtain the anti-bacterial transparent biological hydrogel. The hydrogel is provided with good water retain performance and certain anti-bacterial property, which has good development prospect as soft touch glasses.

Description

technical field [0001] The invention relates to a transparent hydrogel with antibacterial effect and a preparation method thereof, belonging to the fields of new materials and biological materials. Background technique [0002] Chitosan is the most important derivative of the second largest polysaccharide in nature - chitin (Chitin). Positively charged linear polysaccharides can be prepared by deacetylating chitin by alkaline hydrolysis. The unique biological characteristics and physical and chemical properties of chitosan make it have potential broad application value in many aspects. [0003] As a medicine for external use, chitosan has antibacterial properties, can promote the healing of skin tissue, and has the effects of repairing and hemostasis on damaged human epidermal tissue. [0004] Chitosan can be made into biomaterials and applied to the human body, such as calcium phosphate bone cement / chitosan bone filling repair materials, hydroxyapatite / chitosan bone filli...

Claims

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Application Information

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IPC IPC(8): C08F301/00C08F2/48C08J3/075C08F220/00C08B37/08A61K31/722A61P31/04A61P17/02
Inventor 马榴强刘薇姜紫鹏何江川程艳玲谢飞李若慧
Owner BIOCHEM ENG COLLEGE OF BEIJING UNION UNIV
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