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Macroporous adsorption resin special for extracting cephalosporin C and its preparation method

A technology of cephalosporin and adsorption resin, which is applied in the field of macroporous adsorption resin for cephalosporin C extraction and its preparation, which can solve the problems of adsorption resin performance, demanding price, high surface area and porosity

Active Publication Date: 2008-10-22
AMICOGEN CHINA BIOPHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, specific to the adsorption and extraction of cephalosporin C, it is far from enough to only have a higher surface area and porosity. C product quality requirements are increasing day by day, and the performance and price requirements of the adsorption resin used for cephalosporin C are also more stringent. Traditional polymer adsorbents can no longer fully meet the needs of cephalosporin C production.

Method used

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  • Macroporous adsorption resin special for extracting cephalosporin C and its preparation method
  • Macroporous adsorption resin special for extracting cephalosporin C and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: Preparation of special macroporous adsorption resin for cephalosporin C extraction

[0042] A monomer mixture containing 75g (80% content) of divinylbenzene, 8g methyl methacrylate, 17g styrene, 90g toluene and 50g tert-amyl alcohol and 1.0g benzoyl peroxide was added to 500ml anhydrous salt, In the dispersion medium solution composed of 3.5g gelatin, stir to form uniform droplets of a certain size, raise the temperature to 70-75°C, react for 4 hours, then raise the temperature to 85°C, and react for 4 hours. Then the water is drained, hot water is added again, the temperature is raised, and the porogen (toluene and tert-amyl alcohol) is removed by azeotropic distillation until the condensate hardly contains oil, and the distillation is stopped. Lower the temperature, wash the spheres with a large amount of water, drain the water, then dry with hot air until the water content is below 1.0%, and sieve the spheres with 20-60 mesh to obtain 90 g of cross-linked ...

Embodiment 2

[0045] A monomer mixture containing 85g (80% content) of divinylbenzene, 5g methyl acrylate, 15g styrene, 100g toluene, 30g tert-amyl alcohol, 30g isooctane and 1.0g benzoyl peroxide was added to 500ml In the dispersion medium solution composed of no salt water and 3.5 g of gelatin, the remaining operations refer to Example 1 to obtain 95 g of cross-linked macroporous copolymer matrix.

[0046] Add 95g of the cross-linked macroporous copolymer matrix obtained above into 570ml of dichloroethane, stir and swell at room temperature for 2 hours, then add 19g of zinc chloride, raise the temperature to 80°C, and react for 15 hours. With reference to Example 1 for all the other operations, about 300g of brownish-yellow target product cephalosporin C is extracted with special macroporous adsorption resin, and its specific surface area is 1205m 2 / g, the pore volume is 1.84ml / g.

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Abstract

The invention relates to a macro-porous adsorption resin specially used for extracting cephalosporin C and a preparation method for the macro-porous adsorption resin. The specific surface of the adsorption resin is ranging from 1000 to 2000m<2> / g and the pore volume thereof is 1.5-2.5ml / g. The preparation method is that dispersant is firstly dissolved in dispersion medium and mixture consisting of monomer, pore-forming agent and photopolymerization initiator are also added in the dispersion medium, so as to carry out the reaction for 5-10 hours under the suspension polymerization temperature of 60-100 DEG C and to gain the crosslinking macro-porous copolymer substrate; the macro-porous copolymer substrate is disposed by Lewis acid catalyst under the conditions of existence of inert medium and the temperature of 50-120 DEG C and the crosslinking reaction is carried out again inside the substrate. The macro-porous adsorption resin specially used for extracting cephalosporin C of the invention has high adsorption rate, good selection to the object output, easy resolution and regeneration and high purity of the extracted cephalosporin C products.

Description

technical field [0001] The invention relates to a special macroporous adsorption resin for extracting cephalosporin C and a preparation method thereof. Background technique [0002] Bacterial infectious diseases are common and frequently-occurring diseases in people's daily life. Various serious bacterial infections are still an important problem with potential fatal danger. Anti-infective drugs have always been the first variety in the world's hospital market, occupying the The status of the leader. [0003] Judging from the sales of anti-infective drugs in the world, cephalosporin antibiotics come out on top. Cephalosporins, also known as cephalosporins, are a class of broad-spectrum semi-synthetic antibiotics. Compared with penicillins, they have the advantages of wider antibacterial spectrum, resistance to penicillinase, high curative effect, low toxicity, and less allergic reactions. occupy a very important position. Since the first cephalosporin product was launched...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/30C07D501/30
CPCB01J20/28085B01J20/267C07D501/12B01J20/3064B01J20/28066B01J20/26B01J20/28076
Inventor 王玲赵新祥尚新全张玉民颜学锋秦玉艳
Owner AMICOGEN CHINA BIOPHARM CO LTD
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