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Method for preparing gold magnetic core-shell nano-particle

A nanoparticle and composite nanoparticle technology, applied in the field of nanocomposite materials, can solve the problems of insufficient application of nano-gold performance, and achieve the effects of low cost, mild reaction conditions and easy operation.

Inactive Publication Date: 2011-04-06
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In fact, the application of these particles is often limited to using the surface of gold nanoparticles only as a carrier for binding with biomolecules, and the other properties of gold nanoparticles are not comprehensively applied.

Method used

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  • Method for preparing gold magnetic core-shell nano-particle
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  • Method for preparing gold magnetic core-shell nano-particle

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A kind of gold magnetic composite nanoparticle (namely Fe 3 o 4 The preparation method of @Au core-shell composite nanoparticle) comprises the following steps:

[0031] (1) Fe 3 o 4 Preparation of nanoparticles: weigh 0.8g FeCl 2 4H 2 O and 2.08 g FeCl 3 ·6H 2 O, dissolved in 80 mL H 2 O, pass N2 Deoxidize for 30min, then add 80mL of 0.75mol / L NaOH solution dropwise to the above solution, and pass N at 80°C 2 Stirred and reacted for 60 minutes, a black precipitate (Fe 3 o 4 Nanoparticles). After the reaction, cool to 20°C, magnetically separate, wash the black precipitate with water and absolute ethanol in turn, and prepare a 10 mg / mL dispersion with absolute ethanol.

[0032] (2) Fe 3 o 4 Surface modification of nanoparticles: take 10mL of the above dispersion, add 88mL of ethanol / ultrapure aqueous solution (volume ratio of ethanol: ultrapure water is 95:5), ultrasonicate at 60KHz for 10min, add silane coupling agent namely 3-ammonia Propyltriethoxysilane...

Embodiment 2

[0037] A kind of gold magnetic composite nanoparticle (namely Fe 3 o 4 The preparation method of @Au core-shell composite nanoparticle) comprises the following steps:

[0038] (1) Fe 3 o 4 Preparation of nanoparticles: weigh 1.00g FeCl 2 4H 2 O and 2.25 g FeCl 3 ·6H 2 O, dissolved in 150mL water, pass through N 2 Deoxygenation for 30min, then dropwise add 100mL of 0.75mol / L KOH solution to the above solution, pass N at 70°C 2 Stirred and reacted for 40 minutes, a black precipitate (Fe 3 o 4 Nanoparticles). After the reaction, cool to room temperature, magnetically separate, wash the black precipitate with water and absolute ethanol in sequence, and prepare a 10 mg / mL dispersion with absolute ethanol.

[0039] (2) Fe 3 o 4 Surface modification of nanoparticles: take 10mL of the above dispersion, add 88mL of methanol / ultrapure aqueous solution (the volume ratio of methanol:ultrapure water is 95:5), ultrasonicate at 60KHz for 10min, add silane coupling agent namely 3...

Embodiment 3

[0043] A kind of gold magnetic composite nanoparticle (namely Fe 3 o 4 The preparation method of @Au core-shell composite nanoparticle) comprises the following steps:

[0044] (1) Fe 3 o 4 Preparation of nanoparticles: weigh 1.20g FeCl 2 4H 2 O and 2.50 g FeCl 3 ·6H 2 O, dissolved in 150mL water, pass through N 2 Deoxidize for 30min, then add 100mL of 0.75mol / L NaOH solution dropwise to the above solution, and pass N at 90°C 2 Stirred and reacted for 50 minutes, a black precipitate (Fe 3 o 4 Nanoparticles). After the reaction, cool to room temperature, magnetically separate, wash the black precipitate with water and absolute ethanol in sequence, and prepare a 10 mg / mL dispersion with absolute ethanol.

[0045] (2) Fe 3 o 4 Surface modification of nanoparticles: take 10mL of the above dispersion, add 88mL of isopropanol / ultrapure aqueous solution (volume ratio of isopropanol: ultrapure water is 95:5), ultrasonicate at 60KHz for 10min, add silane coupling agent Tha...

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Abstract

The invention discloses a preparation method for gold magnetic composite nanometer particles. Firstly, magnetic nanometer particles of Fe3O4 are prepared by using a chemical co-precipitation method, the surface of the magnetic particles are modified by a silane coupling agent, then with the modified nanometer particles of Fe3O4 as seeds and oil amine as a reduction agent, gold ions are reduced to metallic gold on the surface of the magnetic nanometer particles in an ultrasonic condition, then the nanometer particles are prepared. The nanometer particles have the advantages of good dispersion, strong magnetic response and having double bonds that can lead to polymerization reaction on the surface of the particles. The nanometer particles have the diameter of 30 to 50nm and saturation magnetization of 6.8 to 17.6emu per gram, thus showing super paramagnetism. The nanometer particles not only have magnetic response function, but also can carry out polymerization reaction with a plurality of functional monomers, thus having wide application prospect in a plurality of fields, targeted drug control and release, hyperthermia, isolation of protein and enzyme, etc.

Description

technical field [0001] The invention belongs to the field of nanocomposite materials, in particular to a gold magnetic core-shell nanoparticle (i.e. Fe 3 o 4 Preparation method of @Au (ferroferric oxide magnetic core coated outer gold shell) core-shell composite nanoparticles). Background technique [0002] Magnetic nanoparticles are a new type of material developed in recent years. When the size of magnetic nanoparticles is less than 20nm, they exhibit superparamagnetism. Magnetic nanoparticles provide a variety of possibilities for life science and biotechnology, and have a wide range of applications in biological separation, targeted drug delivery, hyperthermia, and magnetic resonance imaging (MRI) contrast agents. [0003] Gold nanoparticles have excellent electrical and optical properties and good biocompatibility, and are easy to stably combine with biomacromolecules (such as proteins, nucleic acids, peptides), and are widely used in molecular recognition and biomark...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24H01F1/09C04B35/628A61K49/06A61K47/02
Inventor 聂立波张黎明
Owner SUN YAT SEN UNIV
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