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Ion liquid anti-virus activities bactericide, synthesis and application thereof

A technology of ionic liquid and synthesis method, applied in the direction of application, biocide, botanical equipment and method, etc., to achieve the effect of high yield, low cost of raw materials, and strong antibacterial and fungicide activity

Inactive Publication Date: 2009-01-14
JIMEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there has been no report on the simultaneous introduction of ester group and imidazole quaternary ammonium into the highly effective antibacterial α, β-unsaturated carbonyl parent structure

Method used

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  • Ion liquid anti-virus activities bactericide, synthesis and application thereof
  • Ion liquid anti-virus activities bactericide, synthesis and application thereof
  • Ion liquid anti-virus activities bactericide, synthesis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Synthesis of Monoethyl Fumarate-Octyl Methylimidazolium Ionic Liquid Bacteriostasis and Bactericide ([OMIM][MEF])

[0028] 1) Synthesis of monoethyl fumarate (MEF)

[0029] Add 4.93g of maleic anhydride (0.055mol) and 2.88mL of ethanol (0.05mol) treated with anhydrous sodium sulfate into a round bottom flask, heat and stir in an oil bath, react at 80°C for 1h, then add anhydrous AlCl 3 The isomerization agent and petroleum ether were refluxed at 80°C for 2h. After filtration, the filtrate was evaporated to remove the solvent to obtain the crude product. Crude product plus 26mL 2mol L -1 Dissolve in NaOH solution, extract with petroleum ether, adjust the pH of the aqueous phase to 4 with hydrochloric acid, separate the aqueous phase, wash with water, and dry to obtain pure MEF.

[0030] 2) Synthesis of octylmethylimidazolium quaternary ammonium base [OMIM]OH

[0031] Take N-methylimidazole and chloro-n-octane after vacuum distillation in a molar ratio of 1:1.2, and ...

Embodiment 2

[0035] Synthesis of Monooctyl Fumarate-Octyl Methylimidazole Ionic Liquid Bacteriostatic and Bactericide ([OMIM][MOF])

[0036] 1) Synthesis of monooctyl fumarate (MOF)

[0037]Add 0.055mol maleic anhydride and 0.05mol n-octanol into a round bottom flask, heat and stir in an oil bath, react at 60°C for 45min, then add anhydrous AlCl 3 The isomerization agent and petroleum ether were refluxed at 80°C for 2h. After filtration, the filtrate was evaporated to remove the solvent to obtain the crude product. Crude product plus 26mL 2mol L -1 Dissolve in NaOH solution, extract with petroleum ether, adjust the pH of the water phase to 4 with hydrochloric acid, separate the water phase, wash with water, and dry to obtain the pure MOF.

[0038] 2) Synthesis of octylmethylimidazolium quaternary ammonium base [OMIM]OH

[0039] N-methylimidazole and n-octane chloride after vacuum distillation were added to a 250ml single-necked flask in a ratio of 1:1.2 (by molar ratio) in turn, and t...

Embodiment 3

[0043] Synthesis of Fumarate Monophenylethyl Ethyl Octyl Methylimidazole Ionic Liquid Bacteriostatic and Bactericide ([OMIM][MBF])

[0044] 1) Synthesis of monophenylethyl fumarate (MBF)

[0045] Add 4.93g of maleic anhydride and 6.00mL of phenylethyl alcohol into a round bottom flask, heat and stir in an oil bath, react at 60°C for 30min, then add anhydrous AlCl 3 The isomerization agent and petroleum ether were refluxed at 80°C for 2h. After filtration, the filtrate was evaporated to remove the solvent to obtain the crude product. Crude product plus 26mL 2mol L -1 Dissolve in NaOH solution, extract with petroleum ether, adjust the pH of the aqueous phase to 4 with hydrochloric acid, separate the aqueous phase, wash with water, and dry to obtain pure MBF.

[0046] 2) Synthesis of octylmethylimidazolium quaternary ammonium base [OMIM]OH

[0047] N-methylimidazole and n-octane chloride after vacuum distillation were added to a 250ml single-necked flask in sequence at a rat...

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Abstract

The invention relates to ionic liquid bactericidal and bacteriostatic agent, and a synthetic method and the application thereof; the invention relates to ionic liquid bactericidal and bacteriostatic agent, and a synthetic method and the application thereof, in particular to a trans-butene diacid monoester anion base ionic liquid bactericidal and bacteriostatic agent and a synthetic method thereof, and the application of the trans-butene diacid monoester anion base ionic liquid bactericidal and bacteriostatic agent and the synthetic method in preparing bactericidal and bacteriostatic medicine. The invention provides novel series compound ionic liquid bactericidal and bacteriostatic agent, and a synthetic method and the application thereof. First, trans-butene diacid monoester is synthesized, and then alkyl methyl imidazole quaternary ammonium hydroxide is synthesized, and finally the ionic liquid bactericidal and bacteriostatic agent is synthesized. The ionic liquid bactericidal and bacteriostatic agent has very strong activity of bactericidal and bacteriostatic agent, and can be used to prepare anti-bacterial medicine. The synthesis route is short, the synthesis process is simple, the raw material cost is low, the environment pollution is small, the requirements for production equipment and environment conditions are not high, and the purity of the synthesized products is high, the yield is high, and the storage, transportation, packaging and use are convenient; therefore, the ionic liquid bactericidal and bacteriostatic agent is very applicable to large-scale industrialized production.

Description

technical field [0001] The present invention relates to a class of ionic liquid bacteriostatic and bactericidal agents and their synthesis methods and applications, in particular to a class of fumaric acid monoester anion-based ionic liquid bacteriostatic and bactericidal agents and their synthesis methods, and their use in the preparation of bacteriostatic and bactericidal agents application in medicine. Background technique [0002] The solubility of antibacterial agents in oil and water directly affects their antibacterial effect. This is because microorganisms only exist in the water phase, so the antibacterial agent entering the oil phase is actually a loss. Therefore, the design principle of new antibacterial agents is to design antibacterial agents with low oil solubility and high water solubility. Fumarate esters are a class of bacteriostatic agents widely used. They are characterized by broad bactericidal spectrum, low toxicity to other organisms, and good environ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N43/50A01P1/00C07D233/56
Inventor 欧光南周常义何碧烟陈素艳
Owner JIMEI UNIV
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