48 results about "Fumarate Esters" patented technology

A method of making a copolymer composition containing a copolymer, which includes the steps of (a) providing a donor monomer composition that includes an isobutylene type monomer; (b) mixing the donor monomer composition with an ethylenically unsaturated monomer composition that includes one or more ethylenically unsaturated acceptor monomers, and is substantially free of maleate type monomers and fumarate type monomers, and (c) polymerizing the mixture resulting from step (b) in the presence of a free radical polymerization initiator. The polymerization is carried out in the substantial absence of Lewis acids and/or transition metals. The isobutylene type monomer is present at a molar excess of at least 10 mol % based on the molar concentration of monomers in the ethylenically unsaturated monomer composition. The ethylenically unsaturated acceptor monomers are present in an amount of at least 15 mol % of the total monomer composition.

The invention relates to a biodegradable unsaturated polyphosphate ester containing phosphate ester and fumarate ester bonds and discloses a preparation method of the polyphosphate ester and a method for the application of the polyphosphate ester as a medical sustained release preparation for injecting into a treated part and as a hard tissue repair and filling material. The mixture composed of the polyphosphate ester, a cross-linking vinyl monomer, a free radical thermal initiator or photo initiator being capable of initiating or assist in initiating covalent cross-linking reaction and biologically active drugs has excellent medical sustained release effect and no toxic side effects. As a material for repairing the defects of osseous tissue, the biodegradable unsaturated polyphosphate ester can stimulate the formation of new bones; and the material can also be degraded gradually and finally be substituted by a new bone completely. The biodegradable unsaturated polyphosphate ester has outstanding biocompatibility and no obvious inflammation reactions and teratogenesis.

Described herein are pharmaceutical compositions comprising fumarate esters, methods for making the same, and methods for treating subjects in need thereof. In particular, oral pharmaceutical compositions comprising controlled release matrices comprising fumarate esters are described.

The invention relates to a polymer used in lubricating oil pour point depressing, a lubricating oil pour point depressant, and a preparation method thereof. The polymer provided by the invention is a random copolymer of fumarate, vinyl acetate and allyl carbamate. The polymer has a certain dispersion effect, and a good pour point depressing effect.

The invention relates to an engine oil composition, which takes the total weight of the engine oil composition as the reference. The engine oil composition is prepared from the following components in percentage by weight: 0.1 to 0.4 percent of a pour point depressant, 1.5 to 8.0 percent of a viscosity index improver, 1.79 to 3.93 percent of a clearing agent, 0.64 to 3.07 percent of a dispersing agent, 1.04 to 3.67 percent of an antioxidant, 0.01 to 5 percent of a friction reducing agent, 0.3 to 1.5 percent of zinc dialkyl dithiophosphate and the balance of neutral base oil, the pour point depressant comprises a vinyl acetate-fumarate pour point depressant; the vinyl acetate-fumarate pour point depressant is prepared from the following components in parts by weight: 0.4 to 0.6 part of octadecyl fumarate, 0.8 to 1.2 parts of dodecanol fumarate, 0.8 to 1.2 parts of tetradecyl fumarate, 0.8 to 1.2 parts of hexadecyl fumarate and 0.8 to 1.2 parts of octadecyl fumarate. The engine oil composition has good emulsification retention ability, wear resistance and detergency and dispersibility.

The present invention relates to an LC-MS detection method for detecting 9-propenyl adenine. The technical points include the following steps: (1) first determine the chromatographic conditions through the chromatographic column, column temperature and mobile phase; (2) the test sample and the preparation of the reference substance solution; (3) the assay method adopts precise measurement of the reference substance solution and the test solution respectively, injects into the chromatograph, records the chromatogram, and calculates with the peak area according to the external standard method; the test substance does not interfere with 9‑ The detection of propenyl adenine further realizes the present invention. The present invention has the advantages of establishing a LC-MS detection method for determining 9-propenyl adenine in tenofovir disoproxil fumarate. The detection method can accurately detect the content of 9-propenyl adenine; the method has high sensitivity and strong specificity; it can effectively detect the content of 9-propenyl adenine to control the quality of tenofovir disoproxil fumarate.

The invention relates to a preparation method of antiseptic mono-benzyl-methyl fumarate, which belongs to the technical field of food antiseptic, and comprises the following steps that: (1) preparing and isomerizating mono-benzyl-methyl fumarate: isomerized catalyst is added into maleic anhydride and phenylcarbinol after being reacted for a period of time under the reaction temperature, and the maleic anhydride and the penylcarbinol are isomerizated for a period of time to obtain the mono-benzyl fumarate under an isomerization temperature. (2) The mono-benzyl fumarate, methanol and catalyst with certain quantity are sequentially added into a flask to obtain the pure mono-benzyl-methly fumarate. The method adopts maleic anhydride, methanol and phenylcarbinol as raw materials to prepare novel fumarate - mono-benzyl-methyl fumarate, so the obtained compound simultaneously has a good bacteriostatic function and a good oxidation resistant function, and a novel though can be provided to develop a novel multifunctional food additive. The product is developed to a series of food additives having multiple functions.

A radiation-curable composition having a reduced surface energy and including a reactive dye containing at least one radiation-curable substituent and at least one fluorine-containing substituent. The reactive dye may include any anthraquinone, methine, azo, azine, or xanthene dye adapted to contain at least one radiation-curable substituent and at least one fluorine-containing substituent. The radiation-curable substituent may include (meth)acrylate, styrene, vinyl ether, vinyl ester, N-substituted acrylamide, N-vinyl amide, maleate ester, and fumarate ester.

Provided are a resin composition characterized by containing 30-99 mass% of a cellulose resin represented by general formula (1) below, and 70-1 mass% of a fumaric acid ester polymer containing 30 mol% or more of fumaric acid residue units represented by general formula (2) below; an optical compensation film employing the same; and a production method for an optical compensation film. (1) (2) (In the formulas, R1-R3 represent C1-12 substituent groups, and R4 and R5 represent C1-12 alkyl groups.)

The invention discloses a low-fading-tendency crease-proof antirust paint. The invention is characterized in that the antirust paint is prepared from the following raw materials in parts by weight: 3-5 parts of fine sheet glass, 2-3 parts of zirconia, 4-6 parts of titanium white, 3-4 parts of potassium silicate, 1-2 parts of triallyl isocyanurate, 1-2 parts of fumarate, 1-2 parts of 2,6-di-tert-butyl-para-cresol, 4-6 parts of aluminum tripolyphosphate, 2-3 parts of amine benzoate, 12-14 parts of melamine formaldehyde resin, 32-35 parts of E-44 epoxy resin, 1-2 parts of zinc cyanurate, 14-17 parts of amino resin, 10-13 parts of xylene, 10-15 parts of ethyl formate and 4-7 parts of assistant. The paint film has the advantages of high adhesive force, high hardness, high smoothness, low fading tendency, crease proofness and rust prevention; and the added assistant has the sound insulation function, and can reduce the injury of noise to the human body. The paint has the advantages of high cost performance and favorable decoration performance, and is worthy of popularization.

The present invention provides a polymorph of a CDK9 inhibitor and a preparation method for the polymorph and use thereof. Specifically, disclosed are 4-(((4-(5-chloro-2-(((1R,4r)-4-(((R)-1-methoxypropyl-2-yl)amino)cyclohexyl)amino)pyridine-4-yl)thiazole-2-yl)amino)methyl)tetrahydro-2H-pyrano-4-methylnitrile maleate or fumarate or polymorphs thereof and applications thereof. In addition, also disclosed are a pharmaceutical composition containing the substance and an application of the pharmaceutical composition.

The invention provides a bio-based low-VOC (volatile organic compound) water-based emulsion and a preparation method thereof, the bio-based low-VOC water-based emulsion comprises the following components: fumarate, butyl acrylate, 2-ethylhexyl acrylate and limonene oxide; according to the preparation method, the prepared product has advantages of good adhesion, good light transmission and good stability, and can effectively reduce the emission of volatile organic compounds (VOC).

The invention relates to the field of polyaspartic acid ester, and particularly discloses a preparation method of salt-spray-resistant modified polyaspartic acid ester, the salt-spray-resistant modified polyaspartic acid ester and a coating. The preparation method comprises the following steps: dropwise adding maleate or fumarate into aliphatic amine or alicyclic amine, and reacting to obtain polyaspartic acid ester to be modified; the molar ratio of the maleate or fumarate to the aliphatic amine or alicyclic amine is (0.75-0.95): 1 according to the ratio of double bond equivalent in the maleate or fumarate to amino equivalent in the aliphatic amine or alicyclic amine; adding the cardanol modified epoxy resin into the to-be-modified polyaspartic acid ester to react to obtain the salt spray resistant modified polyaspartic acid ester, wherein the molar ratio of the cardanol modified epoxy resin to the to-be-modified polyaspartic acid ester is (0.05-0.5): 1. The modified polyaspartic acid ester prepared by the method has excellent salt spray resistance and water resistance, and is low in viscosity and long in operable time during construction.

The invention discloses a preparation method of extreme-pressure-resistant antioxidant lubricating oil. The preparation method includes the steps: adding aluminum oxide, zirconium oxide, ferroferric oxide, methyl anyl alcohol and sodium tripolyphosphate into a reaction kettle, and performing reaction for 30-40 minutes at the temperature of 80-100 DEG C to obtain liquid A; performing reaction on p-phenylenediamine, 2-amino-4-nitrophenol and phenylethylene fumarate ester copolymers for 25-30 minutes at the temperature of 100-120 DEG C under nitrogen protective atmosphere to obtain liquid B; mixing benzotriazole, cyclohexylamine carbonate, oleic acid ethylene glycol ester, calcium acetylsalicylate, mineral oil, the liquid A and the liquid B, continuing to lead in nitrogen, and performing reaction for 10-15 minutes under microwave-ultrasonic conditions; performing stirring reaction at the temperature of 150-180 DEG C under the pressure of 0.05-0.1MPa until a product is in a semitransparentviscous state; cooling the product to obtain the extreme-pressure-resistant antioxidant lubricating oil.

The invention relates to the technical field of concrete admixtures, in particular to an esterification product for preparing a water reducing agent, a preparation method of the esterification product, a high-workability polycarboxylic acid water reducing agent and a preparation method of the high-workability polycarboxylic acid water reducing agent, and the esterification product for preparing the water reducing agent is excessive unsaturated carboxylic acid and/or unsaturated carboxylic acid anhydride. According to the esterification product for preparing the water reducing agent, the main chain of the polycarboxylic acid water reducing agent is provided with phenoxyethanol and/or phenoxyisopropanol, fumarate and maleate structural units, the polycarboxylic acid water reducing agent with corrosion resistance is obtained, and the corrosion resistance of the polycarboxylic acid water reducing agent is improved. The polycarboxylate superplasticizer prepared by the preparation method does not need to be compounded with a small-molecular preservative, so that the problem of uneven distribution caused by poor compatibility of the preservative and the polycarboxylate superplasticizer does not exist, and the final product is a stable macromolecular structure, so that the polycarboxylate superplasticizer can tolerate high temperature higher than 50 DEG C, and the high-temperature corrosion resistance is more excellent.