52 results about "Fumarate Esters" patented technology

The invention provides photocrosslinkable, injectable, biodegradable oligo(poly(ethylene glycol) fumarate) (OPF) hydrogels made from the photopolymerization of an OPF macromer with UV light and a photoinitiator. Hydrogels with varying mechanical properties and water content can be made with changes in macromer and crosslinking agent concentration in a precursor solution. The biodegradable OPF hydrogels can be injected as a fluid into a bodily defect of any shape, may incorporate various therapeutic agents, e.g., cells and / or growth factors, and may be implanted via minimally invasive arthroscopic techniques.

The present invention provides a polymerizable composition having excellent curing properties and surface hardness, and a cured product made therefrom. Also provided are novel fumarate derivatives containing not less than two fumarate groups in the molecule and capable of ensuring a high degree of copolymerization with terminal alkenyloxy groups, as well as the production method of the derivatives and the derivatives containing the derivatives. polymerizable compositions of materials, and cured products made therefrom.

A method of making a copolymer composition containing a copolymer, which includes the steps of (a) providing a donor monomer composition that includes an isobutylene type monomer; (b) mixing the donor monomer composition with an ethylenically unsaturated monomer composition that includes one or more ethylenically unsaturated acceptor monomers, and is substantially free of maleate type monomers and fumarate type monomers, and (c) polymerizing the mixture resulting from step (b) in the presence of a free radical polymerization initiator. The polymerization is carried out in the substantial absence of Lewis acids and / or transition metals. The isobutylene type monomer is present at a molar excess of at least 10 mol % based on the molar concentration of monomers in the ethylenically unsaturated monomer composition. The ethylenically unsaturated acceptor monomers are present in an amount of at least 15 mol % of the total monomer composition.

Bioresorbable compositions for treating skeletal tissue are disclosed. The biomedical compositions are formed from a polylactide polymer, a polyglycolide polymer, or a poly(lactic-co-glycolic acid) polymer having a relatively low molecular weight. For instance, the average number molecular weight of the polymer is generally less than 10,000, such as from about 500 to about 5,000. Fumarate groups are incorporated into the low molecular weight polymer that provide crosslinking sites. If desired, ethyl-lene oxide groups and ceramic particles may also be incorporated into the polymer for producing compositions having a variety of properties. For example, the biomedical composition of the present disclosure can be used to treat soft skeletal tissue or to treat hard skeletal tissue. The biomedical compositions are biodegradable and can contain various therapeutic, beneficial and pharmaceutical agents that may be released during degradation of the polymer.

A polymerisable photoinitiator according to Formula (I):wherein:R1 and R2 are independently selected from the group consisting of hydrogen, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted alkynyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted alkaryl group, a substituted or unsubstituted aryl or heteroaryl group, a halogen, an ether group, a thioether group, an aldehyde group, a ketone group, an ester group, an amide group, an amine and a nitro group;R1 and R2 may represent the necessary atoms to form a five to eight membered ring;L represents an n+m-valent linking group comprising 1 to 30 carbon atoms;A represents a radically polymerizable group selected from the group consisting of an acrylate group, a methacrylate group, a styrene group, an acryl amide group, a methacryl amide group, a maleate group, a fumarate group, an itaconate group, a vinyl ether group, an allyl ether group, a vinyl ester group and an allyl ester group; andn and m independently represent an integer from 1 to 5.

A copolymer composition that includes a copolymer comprised of at least 30 mol % of residues having the following alternating residues from a donor monomer and from an acceptor monomer. The copolymer contains at least 15 mol % of an isobutylene type donor monomer and at least 15 mol % of an acrylic monomer as an acceptor monomer. The copolymer is substantially free of maleate or fumarate monomer segments and the copolymer composition is substantially free of Lewis acids and transition metals. Also disclosed is a thermosetting composition that includes a reactant comprising functional groups, a crosslinking agent having at least two functional groups that are reactive with the functional groups first reactant, and a copolymer flow control agent that includes the copolymer composition as well as substrates coated with the thermosetting composition.

The present invention relates to a hardenable silicone composition including an irradiation-activated system for temporarily inhibiting the hydrosilylation reaction. Said system includes at least one inhibitor selected from among alpha-acetylenic alcohols, alpha-alpha'-acetylenic diesters, conjugated ene-yne compounds, alpha-acetylenic ketones, acrylonitriles, maleates, fumarates, the mixture thereof, at least one photoinitiator, and tris(trimethylsilyl)silane (TTMSS). The invention also relates to a method for preparing a silicone coating and hard elastomer materials provided comprising said silicone composition.

Suggested are oil-based agrochemical compositions with increased viscosity, comprising (a) biocides, (b) hydrophobic carriers, and (c) polymers selected from the group consisting of poly(meth)acrylates, polymaleates and polyfumarates.

The invention belongs to the drug technology field, and particularly relates to a preparation method of a compound 9-[[(R)-2-[[diethoxy]phosphinyl] methoxy]propyl]adenine (I). The compound can be used for preparing an intermediate of tenofovir disoproxil fumarate (a chemical name: 9-[(R)-2-[[bis[[(isopropoxycarbonyl)oxy]methoxy]phosphinyl]methoxy]propyl]adenine fumarate).

The present invention relates to a resin composition, an optical compensation film using the resin composition, and a method for producing an optical compensation film. The resin composition is characterized in that it contains a cellulose-based resin represented by the following general formula (1): 30 to 99% by weight and 70 to 1% by weight of a fumarate polymer containing 30 mol% or more of fumaric acid diester residue units represented by the following general formula (2) . (In the formula, R1 to R3 each independently represent a substituent having 1 to 12 carbon atoms, and R4 and R5 represent an alkyl group having 1 to 12 carbon atoms.)