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Nano-hydroxyapatite hydrosol, preparation and application in toothpaste

A nano-hydroxyapatite and hydrosol technology, which is applied in chemical instruments and methods, dentistry, phosphorus compounds, etc., can solve the problems of increasing product cost, complex preparation and dispersion technology, and achieve reduced feeding time, easy process control, Energy Saving Effect

Inactive Publication Date: 2009-01-14
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although nano-hydroxyapatite and toothpaste containing nano-hydroxyapatite can be prepared according to the above-mentioned technologies, they cannot simultaneously meet the requirements of cheap raw materials, simple preparation, good dispersion, and convenient addition.
Toothpaste is a mass consumer product with low price, complex preparation and dispersion technology, and unnecessary additives used in too much toothpaste will increase product cost and affect its popularization and application

Method used

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  • Nano-hydroxyapatite hydrosol, preparation and application in toothpaste
  • Nano-hydroxyapatite hydrosol, preparation and application in toothpaste
  • Nano-hydroxyapatite hydrosol, preparation and application in toothpaste

Examples

Experimental program
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Effect test

Embodiment 1

[0026] The first step, the preparation calcium hydroxide content is 10kg of milk of lime of 15wt%, packs in the 25L reactor;

[0027] Second step, in described milk of lime, add 0.3kg glacial acetic acid, stir, obtain mixture;

[0028] The third step is to heat the mixture to 95°C, then gradually add 6kg of dilute phosphoric acid with a phosphoric acid content of 17wt% and continue to stir, the stirring speed is 600r / min, the time for adding dilute phosphoric acid is 3min, continue to react for 6 hours, and finally use 2wt% acetic acid solution adjusted the pH value to 8.0, cooled naturally to obtain nano-hydroxyapatite hydrosol.

[0029] The XRD pattern of the solid matter in the prepared nano-hydroxyapatite hydrosol is as follows figure 1 As can be seen from the characteristics shown in its XRD figure, the solid matter in the colloid is low crystallinity hydroxyapatite; the TEM figure of the nano-hydroxyapatite hydrosol is as follows figure 2 shown, from figure 2 It can...

Embodiment 2

[0037] The first step, the preparation calcium hydroxide content is 10kg of milk of lime of 18wt%, packs in the 25L reactor;

[0038] In the second step, 0.6kg calcium acetate is added in the milk of lime, and stirred evenly to obtain a mixture;

[0039] In the third step, the mixture is heated to 65° C., then gradually add 7.1 kg of dilute phosphoric acid with a phosphoric acid content of 20 wt % and continue to stir at a stirring speed of 800 r / min. The time for adding dilute phosphoric acid is 5 minutes, and the reaction is continued for 8 hours. Adjust the pH value to 8.0 with 2wt% acetic acid solution, and cool naturally to obtain nano-hydroxyapatite hydrosol.

[0040] The prepared nano-hydroxyapatite hydrosol is used to prepare toothpaste, except for the nano-hydroxyapatite hydrosol, the raw materials used in the preparation of toothpaste in the prior art are used in the raw materials for preparing the toothpaste, and the preparation process also adopts the prior art . ...

Embodiment 3

[0047] The first step, the preparation calcium hydroxide content is 10kg of milk of lime of 22wt%, packs in 25L reactor;

[0048] In the second step, 0.8kg calcium acetate is added in the milk of lime, and stirred evenly to obtain a mixture;

[0049] The third step is to heat the mixture to 90°C, then gradually add 5.7kg of dilute phosphoric acid with a phosphoric acid content of 30wt% and continue to stir, the stirring speed is 600r / min, the time for adding dilute phosphoric acid is 10min, continue to react for 12 hours, and finally Adjust the pH value to 8.0 with 2wt% acetic acid solution, and cool naturally to obtain nano-hydroxyapatite hydrosol.

[0050] The prepared nano-hydroxyapatite hydrosol is used to prepare toothpaste, except for the nano-hydroxyapatite hydrosol, the raw materials used in the preparation of toothpaste in the prior art are used in the raw materials for preparing the toothpaste, and the preparation process also adopts the prior art .

[0051] The ra...

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Abstract

The invention discloses a preparing method of nano-hydroxyapatite hydrosol, comprising steps as follows: firstly, the milk of lime which contains 1 to 28wt% calcium hydroxide is prepared and added into a reactor; secondly, acetic acid or calcium acetate is added into the milk of lime and mixed to obtain a mixture; and the molar ratio of acetate and calcium in the mixture is 1-6:10; thirdly, the mixture is heated to 30 to 95 DEG C, 8 to 30wt% dilute phosphoric acid is gradually added and stirred at a speed > 300r / min, the dilute phosphate is added for 1 to 30min, the reaction continues for 3 to 20 hours, the pH value is adjusted by the acetic acid solution to be 7.5 to 8.5, and then the nano-hydroxyapatite hydrosol is obtained after cooling; and the mass of the added dilute phosphoric acid is that: the molar ratio of calcium and phosphorus is between 1.68-1.70:1 after the quantity of calcium of the calcium acetate in the solution is deducted. The method has advantages that the process is simple, and the nano-hydroxyapatite hydrosol prepared can be used in producing toothpastes.

Description

technical field [0001] The invention relates to nano-hydroxyapatite hydrosol, its preparation method and its application in toothpaste. Background technique [0002] Hydroxyapatite is the main component of vertebrate bones and teeth, and has good chemical stability and biocompatibility. Nano-hydroxyapatite has the characteristics of high surface energy, high electrostatic field, and strong polarizing force. It has a very high affinity for tooth enamel and cementum, which can promote the remineralization of the tooth enamel surface and improve the microhardness of the tooth enamel surface. , enhance the resistance to acid, and whiten teeth; in addition, nano-hydroxyapatite can also adsorb polysaccharides such as amino acids, proteins, and dextran, and destroy the formation of cariogenic plaque. Zhou disease is the function of these two kinds of multiple oral diseases. For the preparation of nano-hydroxyapatite and its application in toothpaste, many people have carried out ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C01B25/32A61K8/24A61Q11/00
Inventor 王迎军喻新平魏坤陈晓峰
Owner SOUTH CHINA UNIV OF TECH
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