Method for preparing nicotinic acid by pyridine dicarboxylic acid non-catalysis decarboxylation in high temperature liquid water

A technology of picolinic acid and high-temperature liquid water, which is applied in the field of carboxylic acids, can solve the problems of strict processing requirements, increased equipment investment, environmental pollution, etc., and achieves the effect of high product purity and yield, and simple reaction process
CN101353322AActive Publication Date: 2009-01-28CJ CHEILJEDANG CORP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CJ CHEILJEDANG CORP
Publication Date
2009-01-28

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Abstract

The invention discloses a method for preparing a nicotinic acid by catalysis-free decarboxylation of a dinicotinic acid in high-temperature liquid water. The method comprises the following steps: (1) deionized water and the dinicotinic acid are added to a high-pressure reaction kettle with the mass ratio of the deionized water to the dinicotinic acid being 2:1-8:1, the reaction kettle is stirred, the temperature of the reaction kettle is heated up to cause the mixture in the reaction kettle to boil, and an air exhaust valve is opened for 2-5 minutes; (2) the air exhaust valve is closed, the temperature is continuously heated up to 150-250 DEG C for decarboxylation for 5-60 minutes; (3) decarboxylate is cooled, the pH value thereof is adjusted to 3-4, and crude nicotinic acid is obtained after crystallization; and (4) a nicotinic acid product is obtained after the crude nicotinic acid is decolorized by active carbon, recrystallization and drying in vacuum. The method for preparing the nicotinic acid by catalysis-free decarboxylation has the advantages of no catalyst in the reaction process, solving the pollution problem in the existing nicotinic acid preparation, simple and pollution-free process and high product purity and yield.
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Description

technical field

[0001] The invention relates to carboxylic acids, in particular to a method for preparing nicotinic acid through non-catalytic decarboxylation of pyridinedicarboxylic acid in high-temperature liquid water. Background technique

[0002] Nicotinic acid (Nicotinic acid, CAS No: 59-67-6), also known as nicotine acid, chemical name is pyridine-3-carboxylic acid (Pyridine-3-carboxylic acid), molecular formula C 6 h 5 NO 2 , the structural formula is: ), colorless needle-like crystals, belonging to the vitamin B family. Niacin is an indispensable nutrient for humans and animals, and an important component of coenzyme, mainly found in liver, kidney, muscle, yeast, milk, egg yolk, wheat bran, rice bran, peanuts, fruits and vegetables.

[0003] As an important organic chemical raw material, niacin is widely used in medicine, food and feed industry. In the pharmaceutical industry, as a commonly used vitamin, niacin can prevent and treat various skin diseases and s...

Claims

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