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Artificial cardiac valve stitching ring polyester material with antibiosis function

An artificial heart valve and sewing ring technology, applied in heart valve, medical science, fiber type, etc., can solve the problems of poor histocompatibility of silver coating, reduce the incidence of PVE, paravalvular leakage, etc., and achieve good histocompatibility effect of reducing infective endocarditis and overcoming paravalvular leakage

Inactive Publication Date: 2009-02-11
CHENGDU SOUTHWEST JIAOTONG UNIV SCI & TECH GARDEN MANAGEMENT +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to reduce the incidence of PVE, St. Jude of the United States launched its flagship product Silzone in 1997, which is characterized by a silver coating on the surface of the sewing ring material of its mechanical valve, which can prevent bacterial endocarditis, but In the course of clinical use, problems such as poor histocompatibility of the silver coating and possible paravalvular leakage caused by peeling occurred, and St Jude recalled the product in 2000.

Method used

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  • Artificial cardiac valve stitching ring polyester material with antibiosis function
  • Artificial cardiac valve stitching ring polyester material with antibiosis function
  • Artificial cardiac valve stitching ring polyester material with antibiosis function

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The first specific embodiment of the present invention is a kind of artificial heart valve sewing ring polyester material with antibacterial function, which is made by the following method:

[0024] A, the Dacron non-woven polyester material that the artificial heart valve sewing ring is used will be prepared by every 400cm 2 The polyester material is subjected to 8ml / min, 30min ozone surface activation;

[0025] The polyester material after ozone activation was transferred to another reaction flask, and vacuum degassed for 30 minutes.

[0026] B. React the surface-activated polyester material with an aqueous solution of acrylic acid monomer to graft and copolymerize acrylic acid on the surface; the concentration of the aqueous solution of acrylic acid monomer is 5 wt%, the polymerization reaction temperature is 30° C., and the time is 60 minutes.

[0027] C, the terylene material that the surface graft copolymerization acrylic acid that B step obtains is immersed in t...

Embodiment 2

[0031] A kind of artificial heart valve sewing ring polyester material with antibacterial function is prepared by the following method:

[0032] A, the Dacron non-woven polyester material that the artificial heart valve sewing ring is used will be prepared by every 400cm 2 The polyester material is subjected to 12ml / min, 40min ozone surface activation;

[0033] The polyester material after ozone activation was transferred to another reaction bottle, and vacuum degassed for 60 minutes.

[0034] B. React the surface-activated polyester material with an aqueous solution of acrylic acid monomer to graft and copolymerize acrylic acid on the surface; the concentration of the aqueous solution of acrylic acid monomer is 10 wt%, the polymerization reaction temperature is 40° C., and the time is 120 minutes.

[0035] C, the terylene material that the surface graft copolymerization acrylic acid that B step obtains is immersed in the phosphate buffer solution of 1-(3-dimethylaminopropyl ...

Embodiment 3

[0040] A kind of artificial heart valve sewing ring polyester material with antibacterial function is prepared by the following method:

[0041] A, the Dacron non-woven polyester material that the artificial heart valve sewing ring is used will be prepared by every 400cm 2 The polyester material is subjected to 15ml / min, 50min ozone surface activation;

[0042] The polyester material after ozone activation was transferred to another reaction bottle, and vacuum degassed for 120 minutes.

[0043]B. React the surface-activated polyester material with an aqueous solution of acrylic acid monomer to graft and copolymerize acrylic acid on the surface; the concentration of the aqueous solution of acrylic acid monomer is 25 wt%, the polymerization reaction temperature is 60° C., and the time is 240 minutes.

[0044] C, the terylene material that the surface graft copolymerization acrylic acid that B step obtains is immersed in the phosphate buffer solution of 1-(3-dimethylaminopropyl ...

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Abstract

The invention aims at providing a heart valve prosthesis suture ring Terylene material with an antibacterial function, and a preparation method thereof. An ozone activation method is used for carrying out surface ozone activation to the heart valve prosthesis suture ring Terylene material so as to induce acrylic acid covalent graft polymerization, and then 1-(3-Dimethyl Amino Methyl Propyl)-3-Ethyl Carbodi-imide (EDC) is used for activating a chitosan molecule covalent bonded by carboxyl in a polyacrylic acid chain and according to the antibacterial property of the chitosan molecule, the heart valve prosthesis suture ring Terylene material with the antibacterial function is prepared. The adhesion rate of Staphylococcus epidermidis of the suture ring Terylene material can be reduced by 86 percent to the maximum extent while the adhesion rate of Staphylococcus aureus thereof can be reduced by 94.8 percent. The preparation method related to the suture ring Terylene material is simple, safe and effective. Furthermore, the heart valve prosthesis suture ring Terylene material has excellent blood compatibility.

Description

Technical field [0001] The invention relates to a artificial heart valve sewing ring polyester material for human body made by artificial surface modification method. Background technique [0002] Artificial heart valves are key artificial organs for the treatment of heart valve diseases such as rheumatic heart disease and congenital heart disease. These patients account for about 30% of the total number of heart disease patients. At present, the application of artificial heart valves in the world has reached 300,000 per year. The application in China is more than 30,000 per year, and it is growing at an annual growth rate of 15%. At present, more than 80% of the artificial heart valves used clinically in China are mechanical valves, which have the advantage of excellent durability, but thrombosis and embolism, artificial valve infective endocarditis (Prothetic Valve Endocarditis, PVE) will still occur after implantation and other complications. Among them, prosthetic valv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20A61L27/18A61F2/24D06M14/14D06M15/03D06M11/32D06M13/328D06M101/32
Inventor 王进黄楠杨苹孙鸿冷永祥陈俊英万国江赵安莎游天雪吴熹
Owner CHENGDU SOUTHWEST JIAOTONG UNIV SCI & TECH GARDEN MANAGEMENT
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