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Clean production method of glucuronolactone

A glucuronolactone and clean production technology, applied in fermentation and other fields, can solve problems such as air and water pollution, difficult separation, and many side reactions

Inactive Publication Date: 2009-02-11
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the production process, fuming nitric acid causes serious air and water pollution
The nitric acid oxidation reaction system is relatively complicated, with many side reactions, and most of the separation and purification adopts the freezing separation method, which requires large investment in equipment, high operating costs, high cost, and difficult separation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0008] Embodiment 1, at first, the cornstarch of 50g is mixed with water and is made into the cornstarch milk of 28% by mass fraction, adjusts the pH value of cornstarch milk to 9~10, heats up to 50 ℃ and keeps constant while stirring, then Add ferrous sulfate of 0.1% by weight of cornstarch as an initiator, dropwise add hydrogen peroxide of 9% by weight of cornstarch, react for 2.5 hours, filter with suction, wash and dry to obtain oxidized starch; Emulsion with a fraction of 25%, adjust the pH value to 6.0-6.5, control the gelatinization temperature at 80°C until the oxidized starch aggregate structure disappears, add 20000u / ml α-starch at a ratio of 100u / g oxidized starch after gelatinization Enzyme, after liquefaction for 0.5h, test with iodine solution, until the hydrolyzed solution does not turn blue when it meets iodine solution, heat to boiling and keep for 5min to kill enzyme, then quickly cool down the reaction solution to 60°C, adjust the pH value to 4.5, press Add ...

Embodiment 2

[0009] Embodiment 2, at first, the cornstarch of 100g is mixed with water and is made into the cornstarch milk that mass fraction is 32%, adjust the pH value of cornstarch milk to 9~10, heat up to 48 ℃ and keep constant while stirring, then Add ferrous sulfate of 0.1% by weight of cornstarch as an initiator, dropwise add hydrogen peroxide of 8% by weight of cornstarch, react for 2.5 hours, filter with suction, wash and dry to obtain oxidized starch; Emulsion with a fraction of 25%, adjust the pH value to 6.0-6.5, control the gelatinization temperature at 83°C until the oxidized starch aggregate structure disappears, add 20000u / ml α-starch at a ratio of 120u / g oxidized starch after gelatinization Enzyme, after liquefaction for 0.5h, test with iodine solution, until the hydrolyzed solution does not turn blue when it encounters iodine solution, heat to boiling and keep for 8min to inactivate the enzyme, then quickly cool down the reaction solution to 58°C, adjust the pH value to 4...

Embodiment 3

[0010] Embodiment 3, at first, the cornstarch of 100g is mixed with water and is made into the cornstarch milk that mass fraction is 25%, adjusts the pH value of cornstarch milk to 9~10, heats up to 45 ℃ and keeps constant while stirring, then Add ferrous sulfate of 0.1% by weight of cornstarch as an initiator, dropwise add hydrogen peroxide of 10% by weight of cornstarch, react for 2.5 hours, filter with suction, wash and dry to obtain oxidized starch; For the emulsion with a fraction of 25%, adjust the pH value to 6.0-6.5, control the gelatinization temperature at 75°C until the oxidized starch aggregate structure disappears, and add 20000u / ml α-starch at a ratio of 110u / g oxidized starch after gelatinization Enzyme, after liquefaction for 0.5h, test with iodine solution until the hydrolyzed solution does not turn blue when it meets iodine solution, heat to boil and keep for 10min to inactivate the enzyme, then quickly cool down the reaction solution to 55°C, adjust the pH va...

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PUM

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Abstract

The invention relates to a method for cleaning and producing glucuronolactone, which comprises the steps: firstly, corn starch and water are mixed to prepare corn starch milk to be adjusted, stirred and heated up, and then the mixture is added with an evocating agent and dripped with an oxidizer to react for obtaining oxidized starch; the oxidized starch is mixed with water to prepare emulsion, pH value is adjusted to control the temperature for pasting, and alpha-amylase is added to complete liquefaction; the temperature of reaction liquid is quickly lowered and is added with maltogenic amylase for heat preservation reaction and filtration, and undissolved substance is filtered out to obtain hydrolyzate which is decompressed and distilled, so that concentrated hydrolyzate is obtained; the concentrated hydrolyzate is added with a small quantity of glacial acetic acid and acetic anhydride for the reaction of lactonization for 1h and then is added with absolute ethyl alcohol, glucurolactone which is separated out is filtered, washed and dried, and the finished products are obtained. By adopting the method for producing the glucuronolactone, the productive rate is improved by 2%; as no materials which can cause pollution is used in the course of production, and no substance that forms pollution exists, so that the pollution problem in the process of producing the traditional glucuronolactone is solved fundamentally, thus reducing the production cost.

Description

technical field [0001] The invention relates to a clean production method of glucuronolactone. Background technique [0002] Glucuronolactone is referred to as glucuronolactone, and the name of the preparation is Gantaile (commonly known as Gantong). After glucuronolactone enters the human body, under the catalysis of enzymes, the lactone ring is opened and becomes glucuronic acid to play a role. effect. Glucuronic acid is one of the important detoxification substances in the human body. Therefore, as a liver detoxifier and immune function regulator, glucuronolactone is a conventional liver-protecting medicine, and it can also be used in medicine for the treatment of arthritis and connective tissue diseases, as well as rheumatism and rheumatoid arthritis. Adjuvant therapy; Glucuron and its follow-up products are the main additives of functional beverages, food, weight-loss drugs, cosmetics, etc., which have the functions of replenishing physical fitness, improving hypoxia,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P17/18
Inventor 李祥马建中郭凌华丁洋罗文秀于巧真
Owner SHAANXI UNIV OF SCI & TECH
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