Daucane type sesquiterpenes and preparation method and application thereof

A technology of carotane and sesquiterpene, which is applied in the field of preparation of anti-HBV drugs, new carotane-type sesquiterpene compounds and its preparation, and can solve the problems that patients cannot be cured
CN101375841AInactive Publication Date: 2009-03-04FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2009-03-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the traditional Chinese medicine pharmaceutical field and relates to a dancane sesquiterpene, a preparation method thereof and a new use in the preparation of anti-HBV drugs. The invention extracts the dancane sesquiterpene from S.wilsoniana of Schisandra plant and confirms the anti-HBV activity thereof. The result of the pharmacological test comparison of the compound with the active controlled lamivudine proves that the compound has significant anti-HBV role, low effective concentration and smaller cell toxicity, and the dancane sesquiterpene compound can be used as an active ingredient for preparing the drugs for the treatment of hepatitis B.
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Description

technical field

[0001] The invention belongs to the field of traditional Chinese medicine pharmacy, and relates to a new carotane-type sesquiterpene compound, a preparation method thereof and an application in preparation of anti-hepatitis B virus drugs. Background technique

[0002] According to relevant statistics, there are about 300 million people in the world who are chronic hepatitis B virus (HBV) carriers, and my country accounts for about half of them. Hepatitis B virus infection has become one of the major diseases affecting human health globally. Since HBV infection can lead to chronic hepatitis, cirrhosis and primary liver cancer, it has become one of the nine major diseases affecting human life. Since the relative risk rate of liver cancer among chronic HBV-infected persons compared with non-carriers is 217, about 2 million people die of liver cirrhosis and liver cancer caused by hepatitis B every year in the world, and my country is a high-incidence area of ​​he...

Claims

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