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New use of Qingkailing in improving cognition dysfunction and preventing and treating senile dementia

A technology for improving cognition and dysfunction, applied in the field of medicine, to achieve the effect of improving learning and memory ability, changing synaptic plasticity, and reducing Aβ deposition

Inactive Publication Date: 2009-03-18
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing drugs and treatment methods cannot meet people's needs, so people hope to have a drug with low cost, high cure rate, and effective improvement of brain cognitive dysfunction to prevent and treat senile dementia.

Method used

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  • New use of Qingkailing in improving cognition dysfunction and preventing and treating senile dementia
  • New use of Qingkailing in improving cognition dysfunction and preventing and treating senile dementia
  • New use of Qingkailing in improving cognition dysfunction and preventing and treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1: Experimental Study on Qingkailing Improving Cognitive Impairment in Rats with Rapid Brain Aging

[0041] 1. Materials and methods

[0042] 1.1 Research object

[0043] Fifteen healthy SAMR1 old mice and 45 SAMP88-month-old old mice, half male and half male, were then divided into Aricept treatment group, Qingkailing treatment group, and refined Qingkailing treatment group, 15 in each group.

[0044] 1.2 Behavioral tests

[0045] 1.2.1 Composition of Morris water maze

[0046] The water maze consists of three parts: a circular pool, a platform and a recording system. The diameter of the pool is 90cm, and the height is 50cm. The pool is randomly divided into four quadrants (northeast, southeast, southwest and northwest quadrants). At the beginning of the experiment every day, the pool was filled with water 30cm deep, and 1 catties of milk powder was added to make the water opaque milky white, and the water temperature was kept at about 24°C±1°C. There are ...

Embodiment 2

[0062] Embodiment 2: Qingkailing to Aβ 1-42 Effects of hippocampal injection on cognitive function and neuron synapse in AD rats

[0063] 1 material

[0064] 1.1 Experimental animals

[0065] Fifty second-grade male Sprague-Dawley (SD) rats (aged from 8 to 10 months, weighing 380 to 400 g) were provided by Beijing Weitong Lihua Experimental Animal Center. Placed in an SPF environment (Specific pathogen free), that is, a barrier system (barrier system) for rearing. During the experiment, the animals were free to eat and drink water (except preoperative fasting), the room temperature was 20°C-22°C, the relative humidity was 60%-70%, and the photoperiod was 12h (light from 7:00 to 19:00; light from 19:00 to 7:00 dark).

[0066] 1.2 Drugs and preparation

[0067] Traditional Chinese Medicine Qingkailing Oral Liquid

[0068] Refined Qingkailing Oral Solution

[0069] Aricept was purchased at the First Affiliated Hospital of Tianjin University of Traditional Chinese Medicine....

Embodiment 3

[0174] Example 3 Effect of Qingkailing on ACh content in the brain of SHAMP8 rats with rapid aging

[0175] 1.1 Instruments and equipment

[0176] 582 binary pump, ACH-3 (5μm, 150mm×3mm ID) chromatographic column, pre-column immobilized enzyme reactor, post-column immobilized enzyme reactor, 542 automatic sampler, CH150 column oven, Coulomb array II5600A electrochemical detector, 5040 solid-state microporous electrode (platinum electrode, solid-state palladium electrode): ESA Company, the United States.

[0177] Ultrapure water purification system: Purelab Plus, USA.

[0178] Ultra-speed cryogenic centrifuge: 55P-72, Hitachi, Japan.

[0179] -80°C refrigerator: VXE380 type, Jouan Company, France.

[0180] Syringe microporous membrane filter: water system (0.2μm), organic system (0.45μm), Tianjin Tengda Filter Factory.

[0181] 1.2 Drugs and reagents

[0182] ACh chloride, NE, DA, 2,4-dihydroxyphenylacetic acid (DOPAC), 5-HT, 5-hydroxyindole acetic acid (5-HIAA), homovanil...

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Abstract

The invention relates to a qingkailing preparation and the application of a composition of effective components thereof including baicalin, jasminoidin, cholic acid and mother of pearl to improving cognitive dysfunction, preventing and treating senile dementia. Morris water maze experiments prove that the qingkailing preparation and the effective components thereof can improve the cognitive dysfunction of senescence accelerated mice; an in-vivo experiments prove that the qingkailing preparation can improve plasticity change of Alzheimers disease model rats synapse damage resulting from A beta 1-42 hippocampal injection; an in vitro experiments prove that the qingkailing preparation and the composition of the effective components thereof including baicalin, jasminoidin, cholic acid and the mother of pearl can improve complete cerebral acetylcholine content of the senescence accelerated mice, can cause relative increment in the dopamine and serotonin levels of central nerve by staying the degradation of the acetylcholine, the dopamine and the serotonin, thus improving the intracerebral monoaminergic system activity, therefore, the Morris water maze experiments are possibly related to the effect of the qingkailing formula on improving the cognitive dysfunction and preventing and treating the senile dementia.

Description

technical field [0001] The invention relates to a new use of Qingkailing for improving cognitive dysfunction, preventing and treating senile dementia, and belongs to the field of medicine. Background technique [0002] Alzheimer's disease (AD) is a degenerative disease of the central nervous system mainly characterized by progressive cognitive impairment and memory impairment. With the aging of the world's population, its incidence rate is getting higher and higher, and its impact on the quality of human life and even the threat to survival are becoming more and more obvious. [0003] Since AD ​​was first reported by Alois Alzheimer in 1907, research on its pathogenesis and seeking effective treatment has never stopped. Since Aβ is considered to be the initiating factor and central link of AD, drug researches targeting Aβ are increasing day by day. Although a lot of manpower and material resources have been invested, the research results are very limited. Traditional Chin...

Claims

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Application Information

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IPC IPC(8): A61K36/744A61P25/00A61P25/28A61K31/575A61K31/7048A61K35/32A61K35/56A61K35/618
Inventor 王永炎王忠张占军李澎刘克诚李澎涛张文生
Owner BEIJING NORMAL UNIVERSITY
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