Extraction method of citrus active ingredient

An active ingredient, citrus technology, applied in the field of extraction of citrus active ingredients, can solve the problems of difficult control of product quality, complicated process, high extraction temperature, etc., and achieve the effect of favorable environmental protection, high diffusion coefficient, and less operation steps

Inactive Publication Date: 2009-03-25
HUNAN AGRICULTURAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This extraction method is complicated in process, long in process, and the purity of the extracted product is low. In addition, there are some other disadvantages, such as: most organic solvents for extraction are unhealthy or harmful, subsequent solvent separation is difficult, and solvent residues are inevitable, especially for those containing Starch, sugar and other raw materials with more viscous substances, it is quite difficult to completely remove the organic solvent from the product; the extraction temperature is high, the time is long, the substances that are unstable to light and heat are easily damaged, and the product quality is difficult to control; there are many extraction steps, The process is long, the production efficiency is low, and the product loss is large; the ratio of solvent to raw material is large, the space utilization rate of the extraction kettle is extremely low, the energy consumption is large, and a large amount of waste liquid and waste residue are discharged to the outside world, thereby causing serious pollution to the environment

Method used

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  • Extraction method of citrus active ingredient

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] equipment:

[0010] 1. HA231-50-06 supercritical extraction device produced by Jiangsu Nantong Huaan Supercritical Extraction Co., Ltd.

[0011] 2. Dryer and grinder.

[0012] Extraction medium: supercritical CO 2

[0013] Entrainer: Ethanol

[0014] The process parameters are extraction temperature 35°C, extraction pressure 15MPa, fluid flow rate 2L h -1 , the amount of ethanol entrainer accounts for 2% of the total weight of the extraction medium, and the extraction time is 5 hours.

[0015] The extraction steps are as follows:

[0016] 1. Dry and crush the immature citrus fruits to 20-70 mesh;

[0017] 2, charging, the citrus powder that step 1 obtains is packed in the extraction kettle of supercritical extraction device;

[0018] 3. Adjust the process parameters of the supercritical extraction device to the set process parameters (extraction temperature 35°C, extraction pressure 15MPa, and supercritical CO 2 And the flow control of entrainer ethanol is at 2 ...

Embodiment 2

[0022] Embodiment 2: The equipment and extraction steps are the same as in Embodiment 1, and the process parameters are extraction temperature 60°C, extraction pressure 40MPa, and fluid flow rate 12L h -1 , the amount of ethanol entrainer accounts for 12% of the total weight of the extraction medium, and the extraction time is 5 hours. Under these conditions, the extraction rate of synephrine was 20.5%.

Embodiment 3

[0023] Embodiment three: equipment and extraction step are the same as embodiment one, on the basis of single factor test, have selected extraction temperature, extraction pressure, fluid flow rate, entrainer content that have direct impact on extraction process to carry out L 9 (3 4 ) Orthogonal experiment to optimize supercritical CO 2 The process of extracting the active ingredient synephrine from immature citrus fruit by extraction method, the test parameters and results are shown in Table 1, and the extraction time is 5 hours.

[0024] Table I:

[0025] test

Numbering extraction temperature

/ ℃ extraction pressure

/ MPa fluid flow

/ L·h -1 Entrainer

/ % Synephrine Extraction Rate

/ % 1 1(40) 1(25) 1(8) 1(8) 22.51 2 1(40) 2(30) 2(10) 2(10) 22.09 3 1(40) 3(35) 3(12) 3(12) 21.70 4 2(50) 1(25) 2(10) 3(12) 30.46 5 2(50) 2(30) 3(12) 1(8) 31.10 6 2(50) 3(35) 1(8) 2(10) 29.32

[0026] ...

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Abstract

The invention discloses an orange active ingredient extraction method which dries and crushes orange seedcase or green orange fruit, and then takes supercritical fluid as extraction medium for the extraction. Through the extraction method, the extractive orange active ingredient has high purity without pollution during the extraction process, and the technique is simple; the method can also extract the alkaloid such as the active ingredient synephrine with pertinence. The extraction method provides a new method for the orange active ingredient extraction and utilization.

Description

technical field [0001] The invention relates to an extraction method of citrus active ingredients. Background technique [0002] In addition to being eaten as a fruit, citrus fruit contains certain active ingredients. Acridone alkaloids are one of the important biologically active substances. Rutaceae citrus plants are the main source of natural acridone. Up to now, more than 20 kinds of acridone alkaloids have been isolated from citrus plants. Currently, the alkaloids with high content in citrus fruits mainly include synephrine and N-methyltyramine. Synephrine has the physiological functions of improving metabolism, increasing calorie consumption, improving energy level, oxidizing fat, and losing weight. Therefore, synephrine is often used as the active ingredient in weight-loss drugs. In addition, they also play an important role in anti-cancer, anti-tumor, anti-virus, anti-malarial and anti-leukemia, and are widely used in pharmaceuticals, health food and cosmetics ind...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/752
Inventor 王仁才周鸣谦熊兴耀
Owner HUNAN AGRICULTURAL UNIV
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