Vitamin C microcapsule formulation and preparation method thereof

A vitamin and preparation technology, applied in microcapsules, capsule delivery, pharmaceutical formulations, etc., can solve the problems of difficult control of the reaction process, unstable vitamin C, and unstable feed processing.

Inactive Publication Date: 2009-04-22
GUANGDONG HINAPHARM PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Second, the feed processing process leads to instability
[0005] Second, the instability of vitamin C in feed use
It is characterized by high production costs and difficult control of the reaction process.

Method used

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  • Vitamin C microcapsule formulation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0040] Select 225kg of stearic acid and put it into the chemical tank, heat it to 80°C, and keep stirring until all the auxiliary materials are melted; pump the melted stearic acid from the chemical tank into the batching tank, and at the same time put 100kg of vitamin C that has been accurately weighed into the batching tank , shear and stir for 10 minutes, during which the temperature should be controlled at 80°C; import the prepared materials into the storage tank, and heat the temperature to 80°C-100°C; start the feeding spray device, and put the prepared materials in the storage tank Granulation by spraying; the granules of the finished product are collected by sieving with a 24-80 mesh vibrating sieve. Finally, 313 kg of finished vitamin C microcapsule preparations were obtained, the particle size was 200 μm-700 μm, and the yield could reach 96%.

example 2

[0042] Select 175kg of paraffin wax and stearic acid (1:1) into the chemical material tank, heat to 80°C, and keep stirring until all the auxiliary materials are melted; pump the melted auxiliary materials from the chemical material tank into the batching tank, and at the same time accurately weigh Put 80kg of vitamin C into the batching tank, shear and stir for 8 minutes, during which the temperature should be controlled at 80°C; import the prepared material into the storage tank, and heat the temperature to 80°C-100°C; start the feeding spray device, and put the stored material The materials in the tank are granulated through spray freezing equipment; the finished product granules are collected by sieving with a 24-mesh-80-mesh vibrating sieve. Finally, 245 kg of finished vitamin C controlled-release microcapsule preparations are obtained, the particle size is 200 μm-700 μm, and the yield can reach 96%.

example 3

[0044] Select calcium stearate monoglyceride and fat powder 220kg (2:1) into the chemical material tank, heat to 80°C, stir continuously, until all the auxiliary materials are melted; pump the melted auxiliary materials from the chemical material tank into the batching tank, and at the same time Put 100kg of vitamin C that has been accurately weighed into the batching tank, shear and stir for 8 minutes, during which the temperature should be controlled at 80°C; import the prepared materials into the storage tank, and heat the temperature to 80°C-100°C; start feeding Spray device, granulate the materials in the storage tank through spray freezing equipment; sieve and collect the finished product granules with a 24-80 mesh vibrating sieve. Finally, 303.5kg of finished vitamin C microcapsule preparation (50%) was obtained, the particle size was 200 μm-700 μm, and the yield could reach 95%.

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Abstract

The invention relates to the field of feed additives, and provides a novel vitamin C preparation which is defined as a micro-capsule preparation according to usage characteristics, dissolution rate in stomach and intestine, stability and appearance shaping for effectively improving the use effect of vitamin C in cultivation. Meanwhile, the invention also provides a novel process for producing a sustained-release micro-capsule. The process has great improvement in safety, energy conservation, reduction of materials consumption, production benefit and other aspects.

Description

technical field [0001] The present invention relates to a new preparation of vitamin C added in feed for livestock, poultry and aquatic products, and a processing technology for producing the preparation. Specifically, one or more sustained-release and controlled-release polymer materials and vitamin C are used to prepare a high-efficiency microcapsule preparation, and an industrial production method for producing the microcapsule preparation. Background technique [0002] Vitamin C is widely used in animal feed as a feed additive, but vitamin C in common preparations has three factors that lead to its instability. [0003] First, the instability of its physical and chemical properties. Because vitamin C has a strong reducing property, it is easily oxidized by air under alkaline or acidic conditions, and physical and chemical factors such as ultraviolet rays, heating and metal ions aggravate the destruction of vitamin C. [0004] Second, feed processing causes instability....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/375A61K9/50A61K47/44A61P3/02A61J3/00
Inventor 周玉岩逯佩凤杨龙飞
Owner GUANGDONG HINAPHARM PHARMA CO LTD
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