Artificial nerve implant with path for guiding growth

A technology for artificial nerves and grafts, applied in the field of artificial nerve grafts, can solve problems affecting the repair effect, achieve good biocompatibility, good use effect, and good guiding effect

Active Publication Date: 2009-05-20
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still many unsatisfactory problems in these artificial scaffold materials, especially the configuration problem, whi

Method used

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  • Artificial nerve implant with path for guiding growth
  • Artificial nerve implant with path for guiding growth

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The silk is heated in a weak alkali solution (0.1-10% sodium carbonate or 0.1-10% potassium carbonate) at 50-100°C, and then the treated fiber is washed with distilled water to obtain silk fibroin fiber. Part of the silk prepared above Silk fibroin fibers are dissolved in a ternary system of calcium chloride, ethanol and water at 25-80°C (for example, 25°C, 50°C, and 80°C) (the molar ratio is calcium chloride: ethanol: water = 1: 2:8), the dissolution time is 0.5-6 hours (e.g. 0.5, 3, 6 hours). The dissolved mixed solution is put into a cellulose membrane bag and dialyzed with distilled water. Then, the dialyzed silk fibroin solution is injected into the artificial nerve graft lumen to form a longitudinal distribution of multiple introverted tracks that induce nerve regeneration, and a mold with longitudinal grooves or protrusions on the introverted track, and then dried After that, the forming process is carried out; the preliminarily formed silk fibroin catheter is treate...

Embodiment 2

[0022] Dissolve chitosan with a weak acid. The weak acid is acetic acid (or phosphoric acid, citric acid, lactic acid), with a concentration of 2-15% (for example, 2%, 8%, 15%), and then inject the chitosan solution into a specific mold ( Distribute a number of protruding tracks that induce nerve regeneration in the lumen of the artificial nerve graft formed longitudinally, and the protruding track has longitudinal grooves or protruding molds), and then freeze-dry for molding processing; The formed catheter is treated with sodium hydroxide (1mol / L) solution for a certain period of time (5 minutes to 2 hours), and then washed with sodium hydroxide (1mol / L) solution, 50mmol / L phosphate buffer and distilled water successively to obtain the tape The growth-oriented chitosan artificial nerve graft, the growth-oriented orbit is a protruding orbit, and the protruding orbit has longitudinal grooves or protrusions. Depending on the shape of the mold, the cross-sectional shape of the protru...

Embodiment 3

[0024] The silk is heated in a weak alkali solution (0.1-10% sodium carbonate or 0.1-10% potassium carbonate) at 50-100°C, and then the treated fiber is washed with distilled water to obtain silk fibroin fiber. Part of the silk prepared above Silk fibroin fibers are dissolved in a ternary system of calcium chloride, ethanol and water at 25-80°C (for example, 25°C, 50°C, and 80°C) (the molar ratio is calcium chloride: ethanol: water = 1: 2:8), the dissolution time is 0.5-6 hours (e.g. 0.5, 3, 6 hours). The dissolved mixed solution is put into a cellulose membrane bag and dialyzed with distilled water. Then add a certain amount of nerve growth factor (NGF) to the dialyzed silk fibroin solution, and inject it into the mold (the artificial nerve graft is formed with multiple introverted orbits and introverted orbits that induce nerve regeneration. Mold with longitudinal grooves or protrusions on the upper part), after drying, the molding process is performed; then the methanol solutio...

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Abstract

The invention discloses an artificial neuron implant provided with a guide growth track. The artificial neuron implant comprises a tubular neuron implant, the inside of a lumen of the artificial neuron implant is longitudinally provided with a plurality of inward protruding type tracks inducing neural regeneration, and the inward protruding type tracks are provided with longitudinal grooves or protrusions. Because the inside of the lumen of the artificial neuron implant is longitudinally provided with the tracks, and the tracks are provided with the longitudinal grooves or protrusions, the regenerated nerves are better guided; simultaneously, the artificial neuron implant can combine with cytokines, drugs or seeded cells for treatment.

Description

Technical field: [0001] The invention relates to an artificial nerve graft for bridging injured peripheral nerves and promoting their regeneration and repair. Background technique: [0002] With the acceleration of social modernization and people’s pace of life, more traffic accidents, work-related accidents, sports accidents and other incidents will inevitably occur. At the same time, frequent local wars, violent incidents and natural disasters such as earthquakes will cause peripheral nerves. Injury, clinically but long-distance nerve defects cannot be compensated by end-to-end sutures, they have to rely on grafts to bridge the repair. Although the problem of finding and developing more suitable grafts has been more than one hundred years, in addition to autologous nerves becoming the first choice for neural defect bridging grafts, humans are still looking for ideal ones that can be widely used in clinical practice. Nerve graft replacement. Autologous nerve transplantation has ...

Claims

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Application Information

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IPC IPC(8): A61F2/00A61L27/40
Inventor 杨宇民顾晓松丁斐
Owner NANTONG UNIVERSITY
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