Teniposide injection and preparation method thereof

A technology of niposide injection and teniposide, which is applied in the field of medicine, can solve problems such as drug leakage, thermodynamic instability, and particle size increase, achieve good stability and water solubility, reduce work burden, and improve compliance sexual effect
CN101439043AInactive Publication Date: 2009-05-27SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
Publication Date
2009-05-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the field of medical technology, in particular to a new injection for teniposide mainline and a preparation method of the new injection. Components of the injection include teniposide, Tween 80, phospholipid, a stabilizer and an injection solvent. As no Cremophor EL is contained, compared with existing clinical preparations, not only the teniposide injection has few side effects and good stability and improves the medicine-taking compliance of patients, but also the preparation method of the teniposide injection is simple and easy to operate and the teniposide injection is suitable for large-scale preparation and industrial production.
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Description

technical field

[0001] The invention relates to the technical field of medicine, in particular to a teniposide injection for intravenous injection and a preparation method thereof. Background technique

[0002] Teniposide (Teniposide, Vumon, VM-26) aliases: Teniposide, Wittner, Vierm 26, Podophylloside, Podophylloside, Podophyllothiophene Glycoside, podophylloside. Teniposide is a biological ester base with anti-cancer effect proposed from the plant of the genus Cephalia, which can inhibit the synthesis of eukaryotic protein, depolymerize polyribosomes, and interfere with the function of ribosome sugar. Teniposide is a cycle-specific cytotoxic drug that acts on the cell cycle S 2 Late and G 2 It works by preventing the mitosis of cells. It can also cause single-strand and double-strand breaks of DNA bonds, and its mechanism of action may be caused by the inhibition of type II topoisomerase. Because teniposide has a broad-spectrum anti-tumor activity, it is mainly used c...

Claims

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