Nicarbazin and ethopabate nano suspension agent and preparation method thereof

A technology of ethoxybenzamide and nanosuspension is applied in the directions of amide active ingredients, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve the problem of inconvenient, inaccurate and wasteful administration of drugs. and other problems, to achieve the effect of solving the inconvenience of administration, prolonging the residence time, and improving the bioavailability

Active Publication Date: 2009-06-10
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] 1. It is easy to use. Nicarbazine and ethopabate are made into nano-suspension preparations for drinking water administration. Since the drug particles reach the nanometer level and the suspension system is stable, even the original drug solution can be stable after dilution , evenly suspended in water, not only will not block the drinking fountain, but also fundamentally solve the problems of inconvenient administration, serious waste of medicine and inaccurate dosage

Method used

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  • Nicarbazin and ethopabate nano suspension agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Components:

[0036] Component Dosage

[0037] Nicarbazine 25% (W / V)

[0038] Ethoxylate 1.6% (V / V)

[0039] Ethanol 3% (V / V)

[0040] Sodium Lauryl Sulfate 0.06% (W / V)

[0041] Glycerin 10% (V / V)

[0042] Sodium Citrate 2% (W / V)

[0043] Sodium metabisulfite 0.2% (W / V)

[0044] Methylparaben 0.03% (W / V)

[0045] Purified water 87% (V / V)

[0046] Configuration method:

[0047] (1) Dissolve sodium citrate and sodium metabisulfite in 27ml of purified water, then add nicarbazine, ethopabate, ethanol and sodium lauryl sulfate, and stir to obtain mixture A.

[0048] (2) Take 60% of purified water, add methylparaben, heat to dissolve, place it at room temperature, then add glycerin, and stir to obtain mixture B.

[0049] (3) Pour solution B into solution A, stir and mix well, and then use purified water to fix the solution to 100% (V / V) to obtain mixture C.

[0050] (4) Mixture C is homogenized by a high-pressure homogenizer under a pressure of 100Mpa, and after ho...

Embodiment 2

[0052] Components:

[0053] Component Dosage

[0054] Nicarbazine 12.5% ​​(W / V)

[0055] Ethoxylate 0.8% (W / V)

[0056] Ethanol 2.3% (V / V)

[0057] Sodium Lauryl Sulfate 0.08% (W / V)

[0058] Sodium Carboxymethyl Cellulose 5% (W / V)

[0059] Glycerin 12% (V / V)

[0060] Sodium Citrate 2.5% (W / V)

[0061] Anhydrous sodium sulfite 0.2% (W / V)

[0062] Propylparaben 0.03% (W / V)

[0063] Purified water 86% (V / V)

[0064] Configuration method:

[0065] (1) Dissolve sodium hydrogen citrate into 26ml of purified water, then add nicarbazine, ethopabate, ethanol and sodium lauryl sulfate, and stir to obtain mixture A.

[0066] (2) Take 60ml of purified water, add anhydrous sodium sulfite and propylparaben, heat to dissolve and place it at room temperature, then add sodium carboxymethylcellulose and glycerin, and stir to obtain mixture B.

[0067] (3) Pour mixture B into mixture A and stir to obtain mixture C.

[0068] (4) The mixture C is homogenized by a high-pressure homogenize...

Embodiment 3

[0070] Clinical Efficacy Trial

[0071] 1. Materials

[0072] Premix: nicarbazine, ethopabate premix, purchased from market products.

[0073] Embodiment 1: nicarbazine, ethopabate nano dry suspension.

[0074] 2. Method

[0075] Mix 500 g of the premix into 1000 kg of feed, feed the chickens suffering from coccidiosis at the age of 20 days, and use it continuously for 5 days. Add 500ml of the suspension into 500L of water, mix well, and provide drinking water for 20-day-old chickens suffering from coccidiosis for 5 consecutive days.

[0076] 3. Experimental results

[0077] The therapeutic effect of table 1 premix and embodiment 1 on chicken coccidiosis

[0078]

[0079] As can be seen from the experimental results, compared with the premix, the treatment effect of Example 1 is obviously better than that of the premix, and it is convenient to use and does not waste.

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Abstract

The invention relates to a nicarbazin and ethopabate nano mixed suspension agent and preparation method thereof, the nano mixed suspension agent of the invention can be administrated by drinking, and the stock solution after being diluted can be evenly dispersed in water and can be kept for stable suspension state, the nano mixed suspension agent has characteristics of convenient administration, reduced waste, ensured dose, increased dissolution velocity of the medicament, increased saturation dissolvability of the medicament, prolonged detention time of the medicament in vivo, improved bioavailability and no blocking of the drinking machine, so that the nicarbazin and ethopabate can sufficiently exert medicament effect when treating the chicken coccidiosis.

Description

technical field [0001] The invention belongs to the field of veterinary drugs, in particular to a method for preparing nicarbazine and ethopabate suspension for treating chicken coccidiosis. Background technique [0002] Chicken coccidiosis is a parasitic disease that seriously harms the poultry industry produced by Eimeria. There are 7 species of Eimeria parasitizing in chicken intestines, namely Eimeria tenella, E.acervulina, Eimeria poisonous ( E. necatrix), E. maxima, E. mitis, E. brinetti and E. precocious (E. .praecox). Various coccidia parasitize in different parts of the digestive tract of chickens. Eimeria tenella parasitizes in the cecum, Eimeria heaps parasitizes in the duodenum, Eimeria giant and Eimeria venom Parasitic in the small intestine, Eimeria brucei parasitizes in the lower small intestine and rectum. [0003] With the continuous development of the poultry industry, China's poultry industry has transformed into intensive farming. Although the breedin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/505A61K31/17A61K31/245A61P33/02
Inventor 富艳玲刘爱玲李旭东
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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