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Rare earth ternary complexes, preparation and use thereof

A technology of ternary complexes and rare earth chlorides, which is applied in the application field of antibacterial agents, can solve problems that have not been seen, and achieve the effects of strong antibacterial effect, simple preparation method, and good fat solubility

Inactive Publication Date: 2009-07-22
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report on the ternary complex formed by rare earth elements, thienoyl trifluoroacetone and aromatic carboxylate and its application as a compound antibacterial agent

Method used

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  • Rare earth ternary complexes, preparation and use thereof
  • Rare earth ternary complexes, preparation and use thereof
  • Rare earth ternary complexes, preparation and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] a) Weigh 12mmol TTA and dissolve it in 12ml of ethanol to prepare a thienoyl trifluoroacetone ethanol solution with a concentration of 1mol / L;

[0035] b) Add 24ml of 0.5mol / L aqueous sodium hydroxide solution;

[0036] c) Heat and stir, when the temperature of the solution rises to 60°C, add 10ml of 0.4mol / L LaCl dropwise 3 ·6H 2 O ethanol solution, after dripping, keep stirring for 0.5 to 1 hour;

[0037] d) Add 40ml of 0.1mol / L sodium p-hydroxybenzoate ethanol solution dropwise at 60°C, and keep the reaction for 6 hours after dropping;

[0038] e) Concentrate, filter with suction, wash the filter residue with ethanol for 3 to 4 times, and dry it in vacuum at 60°C for 4 hours to obtain the rare earth ternary complex La(TTA) 3 L·6H 2 O, where L is sodium p-hydroxybenzoate.

[0039] figure 1 The rare earth ternary complex prepared for this embodiment [La(TTA) 3 L·6H 2 O] transmission electron microscope photo. Depend on figure 1 It can be seen that the rare ea...

Embodiment 2

[0043] a) Weigh 3mmol TTA and dissolve it in 10ml of ethanol to prepare a thienoyl trifluoroacetone ethanol solution with a concentration of 0.3mol / L;

[0044] b) Add 3ml of 1mol / L aqueous sodium hydroxide solution;

[0045] c) Heat and stir, when the temperature of the solution rises to 30°C, add 10ml of 0.1mol / L LaCl dropwise 3 ·6H 2 O ethanol solution, after dripping, keep stirring for 0.5 to 1 hour;

[0046] d) Add 2ml of 0.5mol / L sodium p-hydroxybenzoate ethanol solution dropwise at 30°C, and keep the reaction for 8 hours after dropping;

[0047] e) Concentrate, filter with suction, wash the filter residue with ethanol for 3 to 4 times, and dry it in vacuum at 30°C for 8 hours to obtain the rare earth ternary complex La(TTA) 3 L·4H 2 O, where L is sodium p-hydroxybenzoate.

Embodiment 3

[0049] a) Weigh 12mmol TTA and dissolve it in 6ml of ethanol to prepare a thienoyl trifluoroacetone ethanol solution with a concentration of 2mol / L;

[0050] b) Add 6ml of 2mol / L aqueous sodium hydroxide solution;

[0051] c) Heat and stir, when the temperature of the solution rises to 90°C, add 4ml 1mol / L LaCl dropwise 3 ·6H 2 O ethanol solution, after dripping, keep stirring for 0.5 to 1 hour;

[0052] d) Add 10ml of 0.4mol / L sodium p-hydroxybenzoate ethanol solution dropwise at 90°C, and keep the reaction for 4 hours after dropping;

[0053] e) Concentrate, filter with suction, wash the filter residue with ethanol for 3 to 4 times, and dry it in vacuum at 90°C for 2 hours to obtain the rare earth ternary complex La(TTA) 3 L·3H 2 O, where L is sodium p-hydroxybenzoate.

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Abstract

The invention discloses a rare earth ternary complex with a chemical formula of RE(TTA)3 L question mark nH20, wherein, the RE refers to rare-earth ions, the TTA refers to thenoyl trifluoro acetone, the L refers to aromatic carboxylate, the chemical structural formula thereof are shown as right, and n equals to 0 to 7. The rare earth ternary complex has good chemical stability and thermal stability, endures high temperature of 320 DEG C and can be used, stored and transported at normal temperature; the bacteriostatic circle diameters of the rare earth ternary complex against colibacillus and Staphylococcus aureus are all equal to or larger than 20mn, and the minimal inhibitory concentration thereof is lower than 200mug question mark ml , especially the rare earth ternary complex with particle size ranging from 10nm to 300nm has stronger antibacterial action and more obvious antibacterial effect, and the antibacterial capacity in unit dosage of the rare earth ternary complex is better than that of any single ligand. Therefore, the rare earth ternary complex can be used for preparing novel antibacterial materials and is applied to the environmental purification field. In addition, the rare earth ternary complex is characterized by simple preparation method, mild reaction condition and small environmental pollution caused by manufacturing links.

Description

technical field [0001] The present invention relates to a rare earth ternary complex and its preparation method and application, in particular, it relates to a ternary complex formed by rare earth elements, thienoyl trifluoroacetone and aromatic carboxylate and its preparation method and its use as an antibacterial agent. Background technique [0002] With the improvement of human living standards, public health has attracted more and more attention. From the "atypical pneumonia" in the spring of 2003 to the bird flu virus in early 2004 to the "hand-mouth-foot" disease in 2008, the public Soberly aware that health security issues are related to the health and safety of the country and all mankind. Therefore, how to use antibacterial materials to control and eliminate the growth and reproduction of harmful bacteria has become an important topic in the field of science and technology, and has received continuous attention. [0003] The core component of antibacterial materia...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F5/00C07D333/22C07C65/03C07C63/70C07C229/60A01N43/10A01N37/10A01P3/00
Inventor 何其庄沈智慧许东芳夏庆春施阳
Owner SHANGHAI NORMAL UNIVERSITY
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