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Material for promoting operation wound heal and preparation method thereof

A healing material and wound technology, applied in the field of medical materials, can solve problems such as heavy metal allergy, itching, and limited application range, and achieve the effect of promoting repair speed and effect, promoting healing, and promoting wound repair

Active Publication Date: 2009-08-19
重庆大清医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nano-silver and other products are currently used for antibacterial and wound healing, but due to the nature of the material, it is prone to side effects such as heavy metal allergy and itching, which limits the scope of application.

Method used

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  • Material for promoting operation wound heal and preparation method thereof
  • Material for promoting operation wound heal and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Take 200 g of fresh porcine small intestinal submucosa (SIS), cut it and wash it thoroughly with clean water. First, soak in 300ml of 8% (v / v) hydrogen peroxide solution for 8 hours for degreasing treatment, after thorough cleaning, soak in 500ml of chloroform and methanol mixed solution (ratio: 1:1) for 5 hours to remove cells. After thoroughly washing with clean water, use 400ml of trypsin solution with a concentration of 0.1% (g / ml) and a pH of 8.0 for 2 hours to remove the protein, thoroughly wash until the product is clean, and finally pre-freeze and freeze-dry the product at -80°C . It is pulverized to a size of 0.01mm-1mm in diameter with an ultra-low temperature pulverizer, and packed and sealed.

Embodiment 2

[0040] Take 200g of fresh amniotic membrane, cut it and wash it thoroughly with water. First soak 200ml of hydrogen peroxide solution with a concentration of 12% (v / v) for 5h for degreasing treatment, after thorough cleaning, then soak 400ml with a mixed solution of chloroform and methanol (ratio 1:2) for 15 to remove cells. After thoroughly washing with water, use 200ml of trypsin with a concentration of 0.25% (g / ml) and a pH of 8.4 for deproteinization treatment for 1 hour, thoroughly wash until the product is clean, and finally pre-freeze and freeze-dry the product at -80°C. It is pulverized to a size of 0.01mm-1mm in diameter with an ultra-low temperature pulverizer, and packed and sealed.

Embodiment 3

[0042] Take 300 g of fresh porcine small intestinal submucosa (SIS), cut it and wash it thoroughly with water. First, use 300ml of 15% (v / v) hydrogen peroxide solution for degreasing treatment for 1h, after thorough cleaning, soak in 900ml of chloroform and methanol mixed solution (ratio: 1:1) for 2h to remove cells. After thoroughly washing with clean water, use 1000ml of trypsin with a concentration of 0.1% for deproteinization treatment. The treatment time is 28 hours. It was dissolved for 3 days, and the suspended solution was separated into a supernatant. The electrospinning equipment is used to spin and form a flat film-like material. The pressure is 20kV, and the inner diameter of the spinneret is 0.5mm. The distance between the spinneret and the collecting plate is 28cm. Among them, the content of soluble protein in extracellular matrix reaches 81%.

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PUM

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Abstract

The invention provides a material for promoting the healing of operative wounds. The material is a natural biological repair material obtained by subjecting a flake-shaped or membrane-shaped soft tissue or a derivative thereof coming from humans and / or animals to a series of physical, chemical or biological treatment. The biological repair material can be presented as solid or liquid, is fixed onthe operation wounds through a suturing, attaching, smearing or injecting and other surgical method, plays a role in promoting the wounds to heal in a wound healing process, and is convenient, safe and rapid to use. Compared with the conventional operative wound healing material, the material has the advantages of promoting the speed and effect of repairing wounds, preventing wound infection and reducing operation scars after the wounds healing.

Description

technical field [0001] The invention relates to a material for promoting healing of surgical wounds and a preparation method thereof, belonging to the field of medical materials. Background technique [0002] When the human or animal body is subjected to various surgical operations including tooth extraction, or various physical traumas including burns, it often causes damage, fracture and defect of soft tissue and / or bone tissue and nerve tissue, and can cause bleeding and chances of infection. Normally, wounds can heal and repair naturally. The process of natural wound healing and repair includes: closing the wound to limit blood loss and prevent infection; then removing damaged tissue and destroying pathogenic microorganisms through phagocytosis; followed by various types of cells in the surrounding tissue invading the wound site and forming granulation and scar; finally rebuilding the scar tissue and altering the cell population to lead to complete wound healing. [0...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/40
Inventor 李次会
Owner 重庆大清医疗器械有限公司
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