Non-oral preparation of guava leaf total flavonoid aglycone, preparation method and application thereof

A technology of total flavonoid aglycone and guava leaf, which can be applied to the delivery of non-active ingredients such as medical preparations, pharmaceutical formulations, suppositories, etc. question

Inactive Publication Date: 2009-09-02
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the existing technologies have neglected the research on the total flavonoid aglycons of guava leaves, and its effects and applications have been in a blank state.

Method used

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  • Non-oral preparation of guava leaf total flavonoid aglycone, preparation method and application thereof
  • Non-oral preparation of guava leaf total flavonoid aglycone, preparation method and application thereof
  • Non-oral preparation of guava leaf total flavonoid aglycone, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0107] Take 50 g of total flavonoid aglycone of guava leaves, add 5 g of poloxamer, 600-20 g of polyethylene glycol, and add 4000 to 500 g of polyethylene glycol, heat and melt, grind and mix well, and make 1000 suppositories.

Embodiment 2

[0109] Take carbomer 5g, add water to swell for 24 hours, add triethanolamine to adjust the pH to 8, stir well, add 120g of total flavonoid aglycone in guava leaves, 30g of total aglycone in blood flow, 12.5g of azone, 5g of propylene glycol, and Add water to 500g, vibrating mill ultrafine pulverization for 50 minutes, and make a gel.

Embodiment 3

[0111] Take 100 g of total flavonoid aglycones of guava leaves, add 5 g of lecithin, 5 g of propylene glycol, 5 g of eucalyptus oil, and 5 g of azone, and add lanolin to 200 g, ultrafinely pulverize with a vibrating mill for 60 minutes, and subpackage to make an ointment.

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Abstract

The invention discloses a non-oral preparation of guava leaf total flavonoid aglycone, a preparation method and an application thereof, pertaining to the field of traditional Chinese medicine. Total flavonoid glycosides extracted from guava leaves are hydrolyzed to obtain guava leaf total flavonoid aglycone, and the guava leaf total flavonoid aglycone is prepared into a highly efficient preparation by matching with special auxiliary materials, thereby greatly increasing the bioavailability of the guava leaf total flavonoid aglycone. The preparation has significant curative effects in the treatment of coronary disease, angina pectoris, colitis, diabetes and other diseases.

Description

technical field [0001] The invention relates to a traditional Chinese medicine guava leaf extract, in particular to an extract of guava leaf total flavonoid aglycone, and the medicinal use of the extract. It belongs to the field of traditional Chinese medicine. Background technique [0002] Guava leaves are the dry leaves and tender stems with leaves of Psidium guajaoa L., a Myrtaceae plant. Recorded in "Guangxi Standards of Chinese Medicinal Materials", it is called "Ma Guo" in Brown language. It has the effects of invigorating the stomach and eliminating food, astringent intestines and diarrhea, killing insects and itching, astringent and hemostasis. Modern pharmacological studies have shown that guava leaves have hypoglycemic, antibacterial, antiviral, and antioxidant effects. [0003] There are many studies on guava leaves in the literature. Xiaoke Jiangtang Capsules are directly extracted and refined from guava leaves, which contain a large amount of flavonoid glycos...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/51A61K31/352A61K9/00A61K9/02A61K9/06A61K9/70A61K47/34A61K47/24A61K47/22A61K47/46A61P1/00A61P3/10A61P9/10A61K127/00A61K47/10
Inventor 李钦青张佳余
Owner 北京凯瑞创新医药科技有限公司
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