PEG-grafted polysulfone or polyethersulfone hollow fiber membrane and its preparation method and use

A technology of polyethersulfone and fiber membranes, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc., can solve problems such as inability to deduce membrane-forming parameters

Inactive Publication Date: 2011-11-30
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The characteristics of this field determine that ordinary skilled persons in this field cannot derive the membrane-forming parameters for PEG-grafted polysulfone or polyethersulfone from the existing technology for preparing hollow fiber membranes

Method used

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  • PEG-grafted polysulfone or polyethersulfone hollow fiber membrane and its preparation method and use

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preparation example Construction

[0031] The preparation method of the PEG-grafted polysulfone or polyethersulfone hollow fiber membrane comprises the following steps:

[0032] a) After the compound represented by molecular formula I and the compound represented by molecular formula II are mixed in a ratio of 1:3 to 9, they are dissolved in a solvent with a weight ratio of 15 to 30%. The solvent is N-methylpyrrolidone and dimethylformamide , dimethylacetamide and dimethyl sulfoxide or a mixture of several;

[0033] b) stirring, dissolving for 10 to 12 hours, degassing, and obtaining the spinning stock solution;

[0034] c) Two concentric hollow fiber spinnerets are used to extrude the spinning dope through the spinnerets. The ambient temperature is 20-25°C, the relative humidity is 30-80%, and the extrusion speed is 5-20ml / min. The as-spun fibers go through 10-30cm in the environment and then solidify and form in a water bath with a temperature of 50-80°C. The line speed is 5-40m / min.

[0035] The hollow fi...

Embodiment 1

[0047] The PEG molecular weight is 350, the PEG-polysulfone graft product of graft rate 32%, mixes with polysulfone by the ratio of 1: 3, and dissolves in N-methylpyrrolidone by 15% (w / v), stirs Let it dissolve completely for 12 hours and remove the air bubbles. When the room temperature is 20°C and the relative humidity is 50%, the spinning solution is extruded through two concentric hollow fiber spinnerets at a speed of 5ml / min. It is solidified and formed in water at 50°C, and the fluid linear velocity is 5.5m / min.

[0048] The inner diameter of the obtained novel hollow fiber membrane is 1000 μm, the wall thickness is 100 μm, the porosity detected by mercury porosimetry is 78%, the average pore diameter is 0.8 μm, and no albumin interception can be detected.

Embodiment 2

[0050] The PEG molecular weight is 750, the PEG-polyethersulfone graft product of graft rate 16%, mixes with polyethersulfone by the ratio of 1:5, and dissolves in dimethylacetamide by 20% (w / v) , stirred for 12 hours to dissolve it completely, and remove air bubbles. When room temperature is 25°C and relative humidity is 70%, the spinning solution is extruded through two concentric hollow fiber spinnerets at a speed of 12ml / min. It is solidified and formed in water at 75°C, and the fluid linear velocity is 10m / min.

[0051] The inner diameter of the obtained novel hollow fiber membrane is 700 μm, the wall thickness is 100 μm, the porosity detected by mercury porosimetry is 74%, the average pore diameter is 0.11 μm, and the albumin rejection rate is 65%.

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Abstract

The invention discloses a PEG-grafted polysulfone or polyethersulfone hollow fiber membrane and its preparation method and application. : After mixing in a ratio of 3 to 9, it is dissolved in a solvent such as N-methylpyrrolidone with a weight ratio of 15 to 30%, dissolved under stirring for 10 to 12 hours, and degassed to obtain a spinning stock solution. Two concentric hollow fiber spinnerets are used to extrude the spinning dope through the spinnerets at a speed of 5-20ml / min. The as-spun fibers travel 10-30cm in the environment, and then solidify and form in a water bath at a temperature of 50-80°C, with a fluid linear velocity of 5-40m / min. The hollow fiber membrane has the beneficial effect of anti-platelet, protein and small molecule adsorption, and can be used as a hemodialysis device, or used in bioartificial organs for tissue culture of various human or animal cells, drug metabolism, toxicity and pathology research.

Description

technical field [0001] The invention belongs to the cross field of membrane chemistry, material science and tissue engineering, and in particular relates to a polysulfone or polyethersulfone hollow fiber membrane grafted with polyethylene glycol (PEG), a preparation method and application thereof. Background technique [0002] Polysulfone and polyethersulfone are the most commonly used membrane materials in bioartificial organs and hemodialysis, and are usually prepared as hollow fiber membrane reactors. However, their non-specific adsorption to platelets, proteins and small molecules usually greatly weakens its separation function, and even endangers the lives of patients, which has become the most serious problem restricting its application. [0003] The adsorption of polysulfone and polyethersulfone is caused by their hydrophobicity, therefore, there have been some reports of hydrophilic modification for reducing the adsorption of polysulfone and polyethersulfone membrane...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D71/68B01D69/08A61M1/18
Inventor 孟琴张国亮沈冲戴静
Owner ZHEJIANG UNIV
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