Carboxymethyl starch sodium oral solution and preparation method thereof

A technology of sodium carboxymethyl starch and oral solution, which is applied in the field of medicine, can solve the problems of improving immunity, poor taste of oral solution, and children are not easy to accept drugs, etc., and achieves the effects of less adverse reactions, convenient taking and stable quality.

Active Publication Date: 2011-09-14
XIAN LIBANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The presence of sodium chloride in the sodium carboxymethyl starch crude drug makes the sodium carboxymethyl starch solution be salty, thereby making the sodium carboxymethyl starch oral solution mouthfeel poor, and children are difficult to accept the medicine, which will make the sodium carboxymethyl starch Can't play its immune-boosting role well

Method used

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  • Carboxymethyl starch sodium oral solution and preparation method thereof
  • Carboxymethyl starch sodium oral solution and preparation method thereof
  • Carboxymethyl starch sodium oral solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Example 1 - Dialysis

[0055] method:

[0056] Measure 50g of sodium carboxymethyl starch raw material dissolved in 100ml of distilled water, divide into 5 parts, add to 5 dialysis membranes respectively, place the dialysis membranes in 100ml of distilled water for dialysis for 24 hours. Then combine the dialyzate, add 1ml of potassium chromate indicator solution, and titrate with silver nitrate titration solution (0.1mol / L). Every 1ml of silver nitrate titration solution (0.1mol / L) is equivalent to 3.545mg of Cl. The total chlorine content in the raw material medicine of sodium carboxymethyl starch based on the dry product shall not exceed 0.2%. If the requirements are not met, change the dialysis time to 48 hours or even longer.

Embodiment 2

[0057] Example 2-salting out

[0058] method:

[0059] Measure a certain amount of sodium carboxymethyl starch raw material and dissolve it in distilled water to make a saturated solution of sodium carboxymethyl starch, then add 10% aqueous sodium chloride solution to the saturated solution, stir while adding, and the carboxymethyl starch Starch sodium is separated out from the aqueous solution, continue to add 10% sodium chloride aqueous solution until no solid is separated out. The precipitated solid was washed with 80% ethanol-water solution, filtered and dried to obtain the product. About 0.5g of the obtained sodium carboxymethyl starch product was accurately weighed, put in a 250ml Erlenmeyer flask, added 150ml of water and shaken well, then added 1ml of potassium chromate indicator solution, and titrated with silver nitrate titration solution (0.1mol / L) . Every 1ml of silver nitrate titration solution (0.1mol / L) is equivalent to 3.545mg of Cl. The total chlorine cont...

Embodiment 3

[0060] Example 3- Sephadex column separation

[0061] method:

[0062] Weigh 4g of Sephadex G-25 and pack it into a 10cm column according to Sephadex packing rules. Measure 15ml of distilled water to elute the balance. Weigh 0.5g of sodium carboxymethyl starch raw material and dissolve it in 50ml of distilled water, slowly add 5ml of the sample solution along the inner wall of the column with a dropper, after loading the sample, open the outlet and start collecting. Collect 10ml per tube, and collect 20 tubes in total. Continuously add distilled water to the column for elution, keep the water level on the gel bed at 3-5 cm, until 10 ml of No. 20 tube is collected, and close the outlet. Take 20 test tubes, divide the eluate into two according to the order of collection, that is, each tube is 5ml, and arrange them in two rows on the test tube rack. Add silver nitrate titration solution (0.1mol / L) to each tube of the first row of test tubes. 5ml, judge the chloride ion conten...

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Abstract

The invention discloses carboxymethyl starch sodium oral solution and a preparation method thereof; the carboxymethyl starch sodium oral solution mainly contains the following components of: carboxymethyl starch sodium raw material medicine, a sweetening agent, a flavor agent, a metal chelating agent, and a pH regulating agent; in clinical practice, the carboxymethyl starch sodium oral solution can be widely used for the treatment of children recurrent respiratory tract infection due to low immunity and induced bronchitis and asthma thereby.

Description

1. Technical field [0001] The invention relates to the technical field of medicine, in particular to a sodium carboxymethyl starch oral solution and a preparation method thereof. The sodium carboxymethyl starch oral liquid can effectively improve the mouthfeel and enhance the acceptance of children's medicines, thereby improving children's immunity. Clinically, it can be widely used in the treatment of recurrent respiratory tract infection in children caused by low immunity and the bronchitis and asthma induced by it. 2. Background technology [0002] Due to their young age, the development of the immune system is not yet complete, so that the immune defense function is low, and children are often prone to diseases, especially upper respiratory diseases, such as repeated colds, tonsillitis, bronchitis, pneumonia, the U.S. Food and Drug Administration (FDA) published Announcement: Active polysaccharides can significantly reduce the incidence of human diseases. In order to i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/718A61P11/00A61P11/06A61P37/04
Inventor 陈涛胡惠静王惟娇惠民权王汝涛
Owner XIAN LIBANG PHARMA
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