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Livestock cefquinome bletilla striata bioadhesive slow-release capsules

A cefquinome and bioadhesion technology, which is applied in the field of preparation of veterinary drug cefquinome bletilla striata glue bioadhesion sustained-release capsules, can solve the problems of dangerous disease threats, drug residues, high prices, etc., to prolong the residence time and improve the treatment Effect, non-toxic and side effect effect

Inactive Publication Date: 2009-09-23
TIANJIN RINGPU BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main problems of animal products in my country are: first, the threat of dangerous diseases; second, drug residues
Natural materials are non-toxic and have good biocompatibility, but their adhesion and drug release properties are not ideal; synthetic materials have better adhesion and drug release properties, but are expensive and unsatisfactory in safety
Therefore, currently few bioadhesive materials fully meet the requirements

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] Example 1: Preparation of Cefquinoxime Bletilla Gum Bioadhesive Sustained Release Capsules

[0014] a. Preparation of Bletilla striata gum: Bletilla striata 5kg, crushed, added 35L of distilled water, heated in a water bath at 60°C, soaked and stirred, the extract is filtered through four layers of gauze, and the dregs are added with distilled water. Repeat the dipping, combine the filtrate several times, and concentrate. Add 95% ethanol to make the alcohol content reach 70%, and a large amount of white flocculent precipitate will be deposited. Let it stand overnight, filter the next day, recover the ethanol, collect the precipitate, wash 3 times with ethanol, evaporate the ethanol, and dry at about 80℃ , Weighing, smashing, you can get Bletilla striata gum 1.09kg; Bletilla striata gum: It is yellow dry powder, tasteless and odorless, insoluble in ethanol, soluble in water, and a thick colloid. α-Naphthol concentrated sulfuric acid and alkaline copper tartrate test solution...

Embodiment 2

[0016] Example 2: The prepared cefquinoxime and Bletilla gum bioadhesive sustained-release capsules are mainly used to treat dairy cow mastitis caused by Escherichia coli, and swine respiratory diseases caused by Pasteurella multocida or Actinobacillus pleuropneumoniae. The method of administration is mixed material administration, cattle 1 mg / kg body weight once a day for 2 days; pigs 2 ~ 3 mg / kg body weight once a day for 3 days. Animals allergic to b-lactam antibiotics are prohibited from using this product.

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PUM

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Abstract

The invention relates to the technical field of veterinary drugs, and particularly relates to a veterinary drug of cefquinome bletilla striata bioadhesive slow-release capsule prepared by using cefquinome and bletilla striata as raw materials. An aqueous extraction and alcohol sedimentation method is adopted to extract the bletilla striata; the ratio of the cefquinome to the bletilla striata is 1:3; a 10 percent PVP ethanol solution is used as an adhesive; and the drug is made into 20 mesh grains and is filled in capsules. The contents of the cefquinome bletilla striata bioadhesive slow-release capsules can prolong the time for the detention of the drug at focuses, improve the local concentration of the drug in lesions, and have excellent bioadhesive property as well as the same drug release characteristic as a slow-release preparation.

Description

Technical field [0001] The invention belongs to the technical field of veterinary medicines, and particularly relates to the preparation of veterinary medicine cefquinoxime and Bletilla striata bioadhesive sustained-release capsules using cefquinoxime and bletilla striata as raw materials. Background technique [0002] With the development of animal husbandry in our country in the direction of intensive and intensive, the scale of animal husbandry is constantly expanding, and ensuring the quality and safety of animal husbandry products has become an important issue that we need to solve at present. At present, the main problems in my country's animal products are: first, the threat of dangerous diseases; second, drug residues. Among them, drug residues in animal food have endangered people's health. Therefore, the rational use of animal veterinary drugs and health products to control epidemics and drug residues in the production process of animal husbandry is an important issue t...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K36/898A61K9/52A61K47/36A61P31/04
Inventor 李旭东鲍恩东苏建东
Owner TIANJIN RINGPU BIO TECH
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