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Granular preparation of daphniphyllum-polygonum, application and preparation method thereof

A granule preparation, the technology of Fengyao granule, which is applied in the field of medicine, can solve the problems that the finished product rate of Fengyao granule preparation needs to be improved, and achieve the effects of good patient compliance, easy transportation and storage, and suitable sweetness

Inactive Publication Date: 2009-10-07
HAIKOU PHARMA FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Feng Liao Granules has been produced and sold continuously for more than ten years since it was approved for marketing in 1991. It is listed as a national second-class protected traditional Chinese medicine. However, the yield of Fenglian granule preparations in the granulation process needs to be improved

Method used

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  • Granular preparation of daphniphyllum-polygonum, application and preparation method thereof
  • Granular preparation of daphniphyllum-polygonum, application and preparation method thereof
  • Granular preparation of daphniphyllum-polygonum, application and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Screening of the molding process of the Fengyao granule preparation of the present invention

[0021] In this example, the forming process of the Polygonum granules preparation of the present invention is properly screened, and the orthogonal design is adopted, with the particle yield as an index, to screen the best process for increasing the production yield.

[0022] The design of this experiment is the ratio of dextrin to powdered sugar in the molding process (the amount of water extraction extract is 2 parts), the production environment temperature and relative humidity three factors and three levels of orthogonal experiment, the orthogonal experiment conditions are shown in Table 1 , the experimental results are shown in Table 2.

[0023] Table 1 Orthogonal table of the molding process of Fengyao granules

[0024]

[0025]

[0026] Table 2 Orthogonal experiment results of molding process of Fengliao granules

[0027]

[0028] *P(0.05, 2)=19.0...

Embodiment 2

[0030] Example 2 The prescription of Fengyao granule preparation of the present invention

[0031] The water-extraction extract of Polygonum japonica provided by the present invention is prepared by water extraction of Maple japonica and Polygonum punctata according to the ratio of mass and number of 2: 1. The specific method is as follows: take 20000g of maple japonica and 10000g of Polygonum punctatus, and add water for the first time for 6 Double extraction for 1.5 hours, add water for the second time and extract by 4 times for 1 hour, after combining the two extracts, concentrate to a relative density of 1.26±0.01 (boiling measurement), and obtain the water-extracted extract of Polygonum japonica.

[0032] The present embodiment provides a preferred prescription of Fengyao granule preparation of the present invention as follows:

[0033] Maple Polygonum Water Extract 1185g

[0034] Powdered sugar 6519g

[0035] Dextrin 593g

[0036] Make 1000 bags

[0037] The speci...

Embodiment 3

[0038] Example 3 The preparation method of Fengyao granule preparation of the present invention

[0039] The present embodiment provides the preparation method of Fengyao granule preparation of the present invention, and the specific steps are as follows:

[0040] (1) Pre-treatment of medicinal materials: Take 20000g of medicinal materials Auranthus japonica and 10000g of Polygonum caperica, wash them, cut them into 5cm long pieces, and put them in a multi-functional extractor for later use.

[0041] (2) Extraction: extract 2 times, add 6 times of water for the first time, extract for 1.5 hours, add 4 times of water for the second time, extract for 1 hour (both with 2kg pressure, timed after boiling). The total amount of water used for extraction is 10 times, the amount of water added for the first time should be more, because the medicinal materials absorb water before decocting, and there is no problem of water absorption when adding water for the second time, so the amou...

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Abstract

The invention provides a granular preparation of daphniphyllum-polygonum for treating the gastrointestinal tract disease, and application and a preparation method thereof. The granular preparation of daphniphyllum-polygonum is a sugar-type preparation which includes the granular preparation of daphniphyllum-polygonum for treating the gastrointestinal tract disease and including water-extracting ointment of daphniphyllum calycinum and polygonum hydropiper, powdered sugar and dextrin with the mass ratio of 1-5:5-10:0.5-1. The granular preparation of daphniphyllum-polygonum is simple in granulating technology and the extract of the medical material needs not be made into dry powder, the granulating process adopts the ebullated bed one-step granulation technology which reduces dust pollution in industrial production and meets the modernization requirement in the preparation of Chinese traditional medicine. The obtained granular preparation of daphniphyllum-polygonum can be dissolved quickly, has good taste and high bioavailability, and good patient dependence, and is easy to be transported or stored.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular, the invention relates to a traditional Chinese medicine preparation of Feng Liao granule, its application and its preparation method. Background technique [0002] The original prescription of Feng Liao traditional Chinese medicine comes from folk prescriptions in Qionghai County, Hainan Province. Use cool together to harmonize yin and yang, and work hard together to go up and down, so that the stomach and intestines are harmonized, and the up and down are normal. Flavonoids are the king medicine. Modern medical research shows that the main active ingredients of Flavonoids are flavonoids and alkaloids, among which flavonoids include rutin, quercetin, isorhamnetin, etc., and rutin is its main effect One of the ingredients, but not the substance that provides all the therapeutic effects. Generally, the content of rutin is used as an indicator, but it is only used as an indicato...

Claims

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Application Information

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IPC IPC(8): A61K36/704A61K9/16A61P1/00A61P1/04A61P1/06
Inventor 许力宏沙莹张志兰
Owner HAIKOU PHARMA FACTORY
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