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Balloon dilation catheter carried with medicine

A technology for dilating catheters and balloons, which is applied in the field of medical devices, can solve the problems of less effective drugs and more blood loss, and achieve the effect of increasing absorption rate and reducing loss

Inactive Publication Date: 2009-10-07
BEIJING TARGET TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The drug loaded by the existing drug-coated balloon is generally a single drug, and its disadvantage is that the drug is lost in the blood during the delivery process, and the effective drug reaching the target blood vessel is less, and it is difficult for a single drug to be better. The lesions of in-stent restenosis can be treated. Based on the above shortcomings, the present invention provides a balloon dilatation catheter carrying multiple drugs with better therapeutic effect.

Method used

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  • Balloon dilation catheter carried with medicine

Examples

Experimental program
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Effect test

Embodiment 1

[0032] The balloon is made of polymer nylon material, and the developer (50% diatrizoate methyl glucosamine solution) for probucol and rapamycin is dissolved into a solution with a concentration of 1% and 2%, respectively. The balloon is sequentially immersed in the barium sulfate solution of probucol and rapamycin and then dried, repeated 5 times to prepare a balloon carrying probucol and rapamycin, which is connected with the catheter to prepare Balloon dilatation catheter.

Embodiment 2

[0034] The balloon is made of polymer nylon material, 10mg probucol, 5mg paclitaxel and 5mg heparin are mixed with 50mg carrier material polylactic acid respectively, and sprayed on the surface of the balloon in turn to prepare carrying probucol, paclitaxel and heparin The balloon is connected with the catheter to prepare a balloon dilatation catheter.

Embodiment 3

[0036] The balloon is made of polymer nylon material, and 5mg probucol, 5mg paclitaxel and 10mg β-estradiol are mixed with 50mg carrier material polylactic acid respectively, and sprayed on the surface of the balloon in turn to prepare carrying probucol The balloon with paclitaxel and β-estradiol is connected with the catheter to prepare a balloon dilatation catheter.

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Abstract

The present invention relates to a balloon dilation catheter carried with medicine. The invention provided balloon dilation catheter includes a balloon and multiple medicine coated on the balloon, and one of the medicine is probucol. The probucol can not only improve medicine absorptivity of cells in blood vessel greatly, but also can reduce loss of other medicine in blood transportation process at the same time. Comparing with the prior balloon dilation catheter, the invention provided balloon dilation catheter carried with medicine has better impact in preventing and curing restenosis, especially suitable for curing restenosis lesion in vascular stent of coronary artery, carotid artery, renal artery etc, or instead the prior stent to cure primary lesions clinically of slight stenosis, fewer stenosis artery.

Description

Technical field [0001] The present invention relates to the field of medical devices, in particular to a balloon dilatation catheter carrying medicine. Background technique [0002] Intracoronary stent restenosis is mainly caused by excessive neointimal hyperplasia. It is a chronic process. It is generally believed that local drug delivery and a longer period of drug release are necessary to effectively prevent restenosis. At present, there are three main methods for the treatment of in-stent restenosis: (1) Simple balloon dilation can still cause a high restenosis rate (up to 39% to 67%), so it has been rarely used; (2) Blood vessel Although internal brachytherapy can effectively treat in-stent restenosis, it still has a restenosis rate of 16% to 23%, and there are potential problems, such as edge effects, aneurysm-like changes, and operator protection. There are not many domestic applications; (3) Drug eluting stent (DES), which is currently the main method for the treatment of...

Claims

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Application Information

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IPC IPC(8): A61M29/02A61M25/10A61K31/10A61K31/436A61F2/958
Inventor 张昱昕蒲忠杰
Owner BEIJING TARGET TECH
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