Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of polycation compound in related angiogenesis diseases

A polycation and angiogenesis technology, applied in the field of biomedicine, can solve the problems of high production and storage cost, existence of immunogenicity, short half-life and large-scale application, and achieve the effects of easy acquisition, simple and stable properties, and easy storage and transportation.

Inactive Publication Date: 2009-10-21
NANJING UNIV
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, as a protein drug, interleukin-12 has disadvantages such as high production and storage costs, immunogenicity, and short half-life in vivo, which affect large-scale application.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of polycation compound in related angiogenesis diseases
  • Application of polycation compound in related angiogenesis diseases
  • Application of polycation compound in related angiogenesis diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0048] The present invention specifically relates to the application of polycationic compounds in the treatment of angiogenesis-related diseases. In the specific implementation process, it mainly relates to the screening of high-efficiency polycationic compounds, and the application of high-efficiency polycationic compounds to the treatment of angiogenesis-related diseases, such as tumors (including liver cancer, lung cancer, fibrosarcoma), rheumatoid arthritis and other diseases.

[0049] 1. Preparation of the Polycation Compound Library

[0050] 1.1 Preparation of polysaccharide amine by condensation of sugar amine derivatives

[0051] The monosaccharide amine derivatives are condensed according to the method reported in the literature to prepare polysaccharide amines, the reaction conditions and reaction time are controlled, and the size and branched chain of the polysaccharide amines produced are controlled. Taking compound 1 as an example, 2.5%-12.5 % solution, add Lewi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of biochemical medicament, in particular to an application of polycation compound in the treatment of related angiogenesis diseases. The polycation compound can effectively improve the expression of interleukin-12 and downstream cytokine interferon-gamma thereof in-vivo and in-vitro, and regulate organism immunity so as to inhibit the generation of a new blood vessel from multiple links and block the development of related angiogenesis diseases, and can be used for treating related angiogenesis diseases. The polycation compound obtains good curative effect in animal models of tumor and rheumatoid arthritis, and has a wide application prospect.

Description

1. Technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of polycationic compounds in diseases related to angiogenesis. 2. Background technology [0002] Angiogenesis refers to the growth of new capillary blood vessels from pre-existing capillaries and postcapillary venules. Angiogenesis is an extremely complex process, which generally includes steps such as degradation of vascular endothelial matrix, migration of endothelial cells, proliferation of endothelial cells, formation of vascular rings by branching of endothelial cells, and formation of new basement membranes. Angiogenesis not only widely exists in various physiological processes, such as embryonic development, wound healing, endometrial tissue reconstruction in women's menstrual cycle, but also in various pathological processes, such as tumor growth and metastasis, arthritis, rheumatoid arthritis , inflammatory bowel disease, psoriasis, sc...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K31/716A61K31/729A61K38/38A61K38/02A61P35/00A61P19/02
Inventor 张峻峰董磊夏苏华
Owner NANJING UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com