Application of polycation compound in related angiogenesis diseases

A polycation and angiogenesis technology, applied in the field of biomedicine, can solve the problems of high production and storage cost, existence of immunogenicity, short half-life and large-scale application, and achieve the effects of easy acquisition, simple and stable properties, and easy storage and transportation.

Inactive Publication Date: 2009-10-21
NANJING UNIV
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  • Summary
  • Abstract
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Problems solved by technology

However, as a protein drug, interleukin-12 has disadvantages such as high production and storage costs, immunogenicity, and short half-life in vivo, which affect large-scale application.

Method used

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  • Application of polycation compound in related angiogenesis diseases
  • Application of polycation compound in related angiogenesis diseases
  • Application of polycation compound in related angiogenesis diseases

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Embodiment Construction

[0048] The present invention specifically relates to the application of polycationic compounds in the treatment of angiogenesis-related diseases. In the specific implementation process, it mainly relates to the screening of high-efficiency polycationic compounds, and the application of high-efficiency polycationic compounds to the treatment of angiogenesis-related diseases, such as tumors (including liver cancer, lung cancer, fibrosarcoma), rheumatoid arthritis and other diseases.

[0049] 1. Preparation of the Polycation Compound Library

[0050] 1.1 Preparation of polysaccharide amine by condensation of sugar amine derivatives

[0051] The monosaccharide amine derivatives are condensed according to the method reported in the literature to prepare polysaccharide amines, the reaction conditions and reaction time are controlled, and the size and branched chain of the polysaccharide amines produced are controlled. Taking compound 1 as an example, 2.5%-12.5 % solution, add Lewi...

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Abstract

The invention belongs to the technical field of biochemical medicament, in particular to an application of polycation compound in the treatment of related angiogenesis diseases. The polycation compound can effectively improve the expression of interleukin-12 and downstream cytokine interferon-gamma thereof in-vivo and in-vitro, and regulate organism immunity so as to inhibit the generation of a new blood vessel from multiple links and block the development of related angiogenesis diseases, and can be used for treating related angiogenesis diseases. The polycation compound obtains good curative effect in animal models of tumor and rheumatoid arthritis, and has a wide application prospect.

Description

1. Technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of polycationic compounds in diseases related to angiogenesis. 2. Background technology [0002] Angiogenesis refers to the growth of new capillary blood vessels from pre-existing capillaries and postcapillary venules. Angiogenesis is an extremely complex process, which generally includes steps such as degradation of vascular endothelial matrix, migration of endothelial cells, proliferation of endothelial cells, formation of vascular rings by branching of endothelial cells, and formation of new basement membranes. Angiogenesis not only widely exists in various physiological processes, such as embryonic development, wound healing, endometrial tissue reconstruction in women's menstrual cycle, but also in various pathological processes, such as tumor growth and metastasis, arthritis, rheumatoid arthritis , inflammatory bowel disease, psoriasis, sc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/715A61K31/716A61K31/729A61K38/38A61K38/02A61P35/00A61P19/02
Inventor 张峻峰董磊夏苏华
Owner NANJING UNIV
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