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Surface plasma resonance detection method of morphine

A surface plasmon and resonance detection technology, applied in the detection field, can solve the problems of harsh detection environment, poor selectivity, and high cost.

Inactive Publication Date: 2010-12-08
BEIJING INSTITUTE OF TECHNOLOGYGY
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Problems solved by technology

[0007] The purpose of the present invention is to solve the problems of harsh detection environment, high cost and poor selectivity in the detection of drug morphine in the existing SPR technology, and to provide a surface plasmon resonance rapid detection method for drug morphine, which can be applied Direct detection of the drug morphine in bulk samples in organic solvents

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  • Surface plasma resonance detection method of morphine

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Embodiment Construction

[0023] The invention relates to a surface plasmon resonance detection method for drug morphine. It uses an SPR detector with a surface plasmon resonance sensor to generate the free electrons on the surface of the metal film through the evanescent wave generated when the incident light penetrates into the metal film when total internal reflection occurs at the interface between the optical cover glass and the metal film. Surface plasmon, under the condition of an appropriate value of incident angle, surface plasmon and evanescent wave resonate. We use a drug morphine molecular recognition sensitive chip as an optical sensor as the sensor chip of the surface plasmon resonance detector. When the sample to be tested passes through the surface of the sensor chip, if it contains morphine molecules, it will be adsorbed to the sensor chip. Surface, resulting in changes in the refractive index near the surface of the metal film, resulting in changes in the intensity of reflected light,...

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Abstract

The invention discloses a surface plasma resonance detection method of morphine, belonging to the detection technical field. A morphine molecular identification sensitive chip of an optical sensor is taken as a sensing chip of a surface plasma resonance detector, and the surface plasma resonance detector is utilized to detect light intensity change of total reflected light at the interface betweena sample to be detected and the molecular identification sensitive chip to directly determine the morphine content in the sample to be detected when the sample to be detected passing through the sensing chip surface. The detection method has the characteristics of severe environment resistant, high selectivity, fast response and simple operation and not only improves the sensitivity of the methodbut also reduces detection cost accordingly.

Description

technical field [0001] The invention belongs to the technical field of detection and relates to a surface plasmon resonance rapid detection method for drug morphine. Background technique [0002] Morphine (Morphine, MO) is an isoquinoline alkaloid extracted from opium, and is the most important and most abundant active ingredient in opium, with an average content of 10%. Morphine is widely used in clinical treatment because of its strong analgesic effect. However, the highly addictive nature of morphine makes long-term smokers have serious dependence on morphine both physically and psychologically, resulting in serious drug addiction. Morphine is mixed with a variety of chemical agents, and after further processing, it becomes more toxic heroin. The abuse of morphine drugs has brought great harm to people's life and property. Therefore, no matter in the forensic science work or in the medical monitoring process, it is of great significance to realize the trace, sensitive,...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/41
Inventor 韦天新刘建军
Owner BEIJING INSTITUTE OF TECHNOLOGYGY