Metolazone slow-release capsule and method for preparing same

A technology of metolazone and sustained-release capsules, applied in the field of medicine, to achieve the effects of reducing drug resistance, reducing fluctuations and eliminating peak concentrations

Inactive Publication Date: 2009-11-25
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There are no metolazone sustained-release capsules in the products currently on the market, but making metolazone into sustained-release capsules conforms to the characteristics of chronopharmacology and can play a better therapeutic effect on diseases

Method used

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  • Metolazone slow-release capsule and method for preparing same
  • Metolazone slow-release capsule and method for preparing same
  • Metolazone slow-release capsule and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Component weight / 1000 capsules

[0057] Metolazone 10g

[0058] Hydroxypropyl Methyl Cellulose 65g

[0059] Lactose 60g

[0060] Microcrystalline Cellulose 60g

[0061] Magnesium Stearate 5g

[0062] 90% ethanol appropriate amount

[0063] Preparation method: respectively pulverize the raw materials and auxiliary materials of the prescription and pass through a 100-mesh sieve for later use; mix metolazone, hydroxypropyl methylcellulose, microcrystalline cellulose and lactose through a 100-mesh sieve, and mix with an appropriate amount of 90% ethanol To make soft material, granulate with 20 mesh sieve, dry the wet granules at 60±5°C, granulate with 20 mesh sieve; add magnesium stearate, mix well, pack into capsules.

Embodiment 2

[0065] Component weight / 1000 capsules

[0066] Metolazone 10g

[0067] Polyoxyethylene 100g

[0068] Microcrystalline Cellulose 85g

[0069] Magnesium Stearate 5g

[0070] 90% ethanol appropriate amount

[0071] Preparation method: crush the raw materials and auxiliary materials of the prescription separately and pass through a 100-mesh sieve for later use; mix metolazone, polyoxyethylene, and microcrystalline cellulose through a 100-mesh sieve, use an appropriate amount of 90% ethanol to make a soft material, and pass through a 20-mesh sieve Granulate, dry the wet granules at 60±5°C, and sieve through a 20-mesh sieve; add magnesium stearate, mix well, and pack into capsules.

Embodiment 3

[0073] Component weight / 1000 capsules

[0074] Metolazone 10g

[0075] Sodium Alginate 90g

[0076] Lactose 50g

[0077] Microcrystalline Cellulose 45g

[0078] Magnesium Stearate 5g

[0079] 90% ethanol appropriate amount

[0080] Preparation method: crush the raw materials and auxiliary materials of the prescription respectively and pass through a 100-mesh sieve for later use; weigh the prescribed amount of metolazone, sodium alginate, microcrystalline cellulose and lactose, pass through a 100-mesh sieve and mix evenly, and use an appropriate amount of 90% ethanol To make soft material, granulate with 20 mesh sieve, dry the wet granules at 60±5°C, granulate with 20 mesh sieve; add magnesium stearate, mix well, pack into capsules.

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Abstract

The invention belongs to the technical field of medicaments, and discloses a metolazone slow-release capsule and a method for preparing the same. The preparation comprises an active component of metolazone and a pharmaceutically acceptable carrier component by weight percentage: 1 to 30 percent of metolazone, 10 to 70 percent of auxiliary material with slow-release effect, and the balance of other auxiliary materials. The method comprises the following steps that: (1) matters in a capsule are matrix type particles or pills; (2) the medicine-containing pill is prepared first, and then a slow-release preparation is prepared; and (3) the capsule is the coated slow-release preparation. The metolazone slow-release capsule can ensure that the main medicinal component of metolazone is continuously and regularly released when the metolazone slow-release capsule is orally taken; moreover, the metolazone slow-release capsule has the characteristics of convenient drug administration, persistent curative effect, stable curative effect, little side effect and the like.

Description

Technical field: [0001] The invention relates to the technical field of medicine, in particular to metolazone sustained-release capsules and a preparation method thereof. Background technique: [0002] Metolazone is a non-thiazide diuretic, which is different from hydrochlorothiazide. It acts not only on the distal convoluted tubule and the distal end of the ascending branch of the loop, but also on the proximal convoluted tubule. The diuretic effect is 10 times that of hydrochlorothiazide. , the diuretic period is long, one dose can maintain the diuretic effect for 12 to 24 hours, and the diuretic effect does not weaken when the renal function declines. It is very effective for patients with renal insufficiency who cannot use diuretics such as thiazide. This product can be used For patients allergic to thiazides, etc. Clinically, metolazone is mainly used to treat edema and hypertension. In addition, metolazone also has a good effect in the treatment of chronic cardiac in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/52A61K47/32A61K47/34A61K47/36A61K47/38A61K47/40A61K31/517A61P7/10A61P9/04A61P9/12A61K47/10
Inventor 李三鸣刘洪卓徐路王齐放王中彦
Owner SHENYANG PHARMA UNIVERSITY
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