Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing 5,6,7,4'-tetrahydroxyflavone

A kind of technology of tetrahydroxyflavone and compound, applied in the field of medicine

Active Publication Date: 2011-08-17
KPC PHARM INC
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, the drug application of 5,6,7,4'-tetrahydroxyflavone in the treatment of senile dementia, memory loss, diabetes, arthritis, osteoporosis There are no literature and patent reports on the research

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing 5,6,7,4'-tetrahydroxyflavone
  • Method for preparing 5,6,7,4'-tetrahydroxyflavone
  • Method for preparing 5,6,7,4'-tetrahydroxyflavone

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0141] Example 1: Weigh 20.0g of breviscapine raw material, add 500ml of ethylene glycol, 1ml of 4% dilute hydrochloric acid, heat and reflux for 4 hours, filter the product, and dry it to constant weight to obtain 5,6,7,4' -Tetrahydroxyflavone 10.6g, the purity is 96.2% through high performance liquid phase detection. Recrystallize with 60% methanol, filter, and dry to constant weight to obtain 10.1 g of fine product, the purity of which is 98.9% by HPLC.

Embodiment 2

[0142] Example 2: Weigh 15.0g of breviscapine raw material, add 300ml of 1,2-propanediol, 1ml of 5% dilute sulfuric acid, heat and reflux for 3 hours, filter the product, and dry it to constant weight to obtain 5, 6, 7, 7.9g of 4'-tetrahydroxyflavone, the purity is 95.8% by HPLC. Recrystallize with ethanol, filter, and dry to constant weight to obtain 7.1 g of fine product, the purity of which is 99.5% by HPLC.

Embodiment 3

[0143] Example 3: Weigh 12.0 g of scutellarin raw material, add 400 ml of n-butanol, 1 ml of 5% dilute nitric acid, heat and reflux for 5 hours, filter the product, and dry it to constant weight to obtain 5, 6, 7, 4' - 6.5g of tetrahydroxyflavone, the purity of which is 95.7% as detected by high performance liquid phase. Recrystallize with acetone, filter, and dry to constant weight to obtain 5.8 g of fine product, the purity of which is 99.9% by HPLC.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a method for preparing a 5,6,7,4'-tetrahydroxyflavone compound, which is characterized by comprising the following steps: taking breviscapinun as a raw material, and performing heating reflux reaction between the breviscapinun and alcohol under the catalysis of acid, namely adding 200 to 500 ml of alcohol substance and 1 to 3 ml of 4 to 5 percent acid into 12 to 20 g of thebreviscapinun for the heating reflux reaction; and filtering a product, and drying to a constant weight to obtain 5,6,7,4'-tetrahydroxyflavone shown in a formula I. Experiments prove that the 5,6,7,4'-tetrahydroxyflavone shows obvious strengthening effect on acquisition, consolidation and representation of brain memory of a mice model of alzheimer disease, has obvious improving effect on learningmemory of the mice model with memory loss caused by anisodine of an M-cholinergic inhibitor, and can obviously improve the recent memory and long-term memory capacities of mice. The experiments also prove that the 5,6,7,4'-tetrahydroxyflavone has the effect of treating arthritis, and also has good treating effects on diabetes mellitus and osteoporosis.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a method for preparing 5,6,7,4'-tetrahydroxyflavone by using scutellarin as a raw material. Background technique [0002] Erigeron breviscapus (Vant.) Hand-Mazz, also known as Erigeron breviscapus (Vant.) Hand-Mazz, belongs to the genus Asteraceae. It has the functions of promoting blood circulation and removing blood stasis, dispelling cold and relieving the exterior, relaxing meridian and activating collaterals, etc. It is often used clinically to treat cardiovascular and cerebrovascular diseases . Breviscapine is an active ingredient of flavonoids extracted from the whole plant of Breviscapus breviscapus. Its main ingredient is scutellarin, and it also contains breviscapine A and other ingredients. At present, scutellarin has been mass-produced on a large scale in many domestic manufacturers, and is widely used as a raw material drug. The scutellarin sold in the market gene...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/30A61K31/352A61P25/28A61P3/10A61P19/02A61P29/00A61P35/00A61P19/10
Inventor 周荣光
Owner KPC PHARM INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com