Capsule preparation for treating bruise as well as bleeding and easing pain and preparation method and use thereof

A preparation and capsule technology, applied in the field of medicine, can solve the problem of few varieties of drugs

Active Publication Date: 2010-01-06
HENGKANG MEDICAL GROUP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the current market, although there are many kinds of Chinese patent medicines for the treatment of soft tissue injury and irregular menstruation, they can also treat bruises, bleeding, and relieve pain. There are few drugs

Method used

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  • Capsule preparation for treating bruise as well as bleeding and easing pain and preparation method and use thereof
  • Capsule preparation for treating bruise as well as bleeding and easing pain and preparation method and use thereof
  • Capsule preparation for treating bruise as well as bleeding and easing pain and preparation method and use thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1: the production technology of capsule preparation of the present invention and research thereof

[0061] 1.1 Prescription

[0062] Duyiwei 1000g Notoginseng 1000g Appropriate amount of starch

[0063]

[0064] Make 1000 capsules

[0065] 1.2 Preparation method

[0066] Take 1000g of unique medicinal material, grind it, add 8 times of water to decoct 3 times, each time for 1 hour, combine the decoction, filter, concentrate the filtrate to a relative density of 1.05 (60°C), let it cool, and add it to the processed 5kgD 101 On the resin column, add 15L of water to elute, then elute with 5L of 30% ethanol, collect the 30% ethanol eluate, recover the ethanol and concentrate it to a relative density of 1.10-1.15 (60°C), and set aside; take another 1000g of Sanqi medicinal material, Pulverize, add 8 times the amount of 70% ethanol, reflux extraction 3 times, 1 hour each time, combin...

Embodiment 2

[0069] Embodiment 2: Determination of the unique process route

[0070] 2.1 Pharmacodynamics test of different extraction solvents for unique flavor

[0071] The present inventor compared the main drug efficacy of the extract obtained from the extraction with different extraction solvents from the two aspects of analgesia and hemostasis by using the mouse writhing method and the tail docking method.

[0072] (1) Material

[0073] Samples 1-3: all are tan extracts, which are extracted from the unique medicinal material with water, 50% ethanol, and 95% ethanol respectively. The crude drug content per gram is 5.0g, 7.14g, and 12.5g, respectively. : 6g crude drug / day.person, provided by Gansu Duyiwei Biopharmaceutical Co., Ltd., prepared with normal saline to an appropriate concentration before use. Compound Paracetamol Tablets: white tablets, specifications: 0.3g / tablet, produced by Jilin Province Baikang Pharmaceutical Co., Ltd., batch number: 20070102, prepared with normal ...

Embodiment 3

[0112] Embodiment 3: the preferred test method, data and conclusion of unique process

[0113] 3.1 Process research evaluation index and measurement method

[0114] According to the aforementioned literature and pharmacological screening research data, it is determined that luteolin and extract yield are used as process research evaluation indicators. The determination method is proposed as follows:

[0115] (1) Luteolin was determined according to high performance liquid chromatography (Appendix VI D of Chinese Pharmacopoeia 2005 edition).

[0116] Chromatographic conditions and system suitability test Octadecylsilane bonded silica gel was used as filler, methanol-0.4% phosphoric acid solution (55:45) was used as mobile phase; detection wavelength was 350nm. The number of theoretical plates should not be less than 1500 based on the luteolin peak.

[0117] Preparation of Reference Substance Solution Accurately weigh an appropriate amount of luteolin reference substance, a...

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Abstract

The invention provides a capsule preparation for treating bruises as well as bleeding and easing pain and a preparation method and uses thereof. The capsule preparation provided by the invention is prepared from 1 part of lamiophlomis rotata and 0.1-50 parts of Panax pseudo-ginseng, wherein a lamiophlomis rotata extractive serves as a bond, and a Panax pseudo-ginseng extractive and a pharmaceutically acceptable loading agent, such as starch, serve as basic material to fabricate pellets. The invention also provides a method for preparing the capsule preparation and applications of the capsule preparation in preparing medicines for treating bruises as well as bleeding and easing pain. Meanwhile, the invention also provides the lamiophlomis rotata extractive and the Panax pseudo-ginseng extractive which are prepared by using the invention.

Description

technical field [0001] The invention relates to a capsule preparation for concurrently treating bruising, bleeding and analgesia, its preparation method and application, and belongs to the technical field of medicine. Background technique [0002] In the current market, although there are many kinds of Chinese patent medicines for treating soft tissue injury and irregular menstruation respectively, there are few kinds of medicines for treating bruises, bleeding, and analgesia. These products are mainly used as medicines with crude extracts. The present invention integrates the two surgical essential medicines into one side, integrates the functions of removing blood stasis, stopping bleeding, relieving pain and reducing swelling, can synergize and synergize, and the curative effect is more definite through modern purification technology. It can be seen that the present invention has its obvious particularity, innovation, advancement and practicability, so it has a good mark...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/53A61K9/48A61P7/04A61P29/00
Inventor 张康宁廖立东杨婷
Owner HENGKANG MEDICAL GROUP CO LTD
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