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Method for preparing O-carboxymethyl chitosan nanoparticles

A carboxymethyl chitosan and nanoparticle technology, which is applied in chemical instruments and methods, other chemical processes and other directions, can solve the problem of no preparation method of O-carboxymethyl chitosan nanoparticles, and achieves easy industrial production, The effect of mild reaction conditions and simple production process

Inactive Publication Date: 2010-01-06
NANCHANG HANGKONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are many reports on the adsorption of chitosan to heavy metal ions, but there is no preparation method for O-carboxymethyl chitosan nanoparticles.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] The invention uses chitosan with a degree of deacetylation of 92% as a raw material, reacts it with isopropanol of chloroacetic acid under alkaline conditions to generate O-carboxymethyl chitosan. Measure 10ml of 0.6mg / ml O-carboxymethyl chitosan solution in a three-necked flask, and slowly add 0.4mg / ml sodium polyphosphate solution dropwise under continuous magnetic stirring at a rate of 20-40 drops / min, stop dropping after the solution presents obvious opalescence. It can be seen from the transmission electron microscope that the shape of the O-carboxymethyl chitosan nanoparticles is more regular spherical, and the particle size is about 430nm.

Embodiment 2

[0012] Measure 10ml of 1.0mg / ml O-carboxymethyl chitosan solution in a three-necked flask, and slowly add 0.4mg / ml sodium polyphosphate solution dropwise under continuous magnetic stirring at a rate of 20-40 drops / min, stop dropping after the solution presents obvious opalescence. It can be seen from the transmission electron microscope that the shape of the O-carboxymethyl chitosan nanoparticles is relatively regular spherical, and the particle diameter is about 500nm. The particle size in Example 2 is larger than that in Example 1, which is mainly due to the increase in the concentration of the reactant O-carboxymethyl chitosan.

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Abstract

The invention relates to a method for preparing O-carboxymethyl chitosan nanoparticles, which is characterized by comprising the following steps: dissolving 1.0g of chitosan in 20ml of acetic aqueous solution with a volume ratio of 1 percent, stirring to dissolve the chitosan, adding 20ml of isopropanol solution into dissolved chitosan colloid, stirring to fully and uniformly mix the mixture, soaking for 17 hours at room temperature, then adding 42 percent potassium hydroxide solution, and stirring to acquire white chitosan deposits in the shape of short fibers. The method has the advantages of mild reaction condition, simple production technology and easy industrialized production, and the acquired O-carboxymethyl chitosan nanoparticles have no toxicity or harm, and can be used for adsorbing toxic metal ions.

Description

technical field [0001] The invention relates to a method for preparing nanoparticles, in particular to a method for preparing O-carboxymethyl chitosan nanoparticles. Background technique [0002] Chitosan, whose chemical name is β-(1,4)-2-acetylamino-2-deoxy-D-glucose, is the product of deacetylation of chitin, and is composed of glucosamine and acetylglucosamine structural units. chain polysaccharides. As a positively charged natural polysaccharide, chitosan is a natural biopolymer chelating adsorbent with good performance. It has a strong adsorption force for transition metal ions and can be used to remove various toxic metal ions, such as Cu2+, Ni2+, Zn2+, Cd2+, Hg2+, Cr3+, VO2+ and UO2+ have good application prospects in environmental protection, especially in water treatment. The modified nanoparticles have expanded solubility range and good water solubility, and are used as an adsorbent for heavy metal ions, and have good adsorption performance. The modified chitosa...

Claims

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Application Information

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IPC IPC(8): C08L5/08C08K3/32C08J3/075B01J20/24B01J20/30
Inventor 谢宇陈平吴翠兰罗彧斌黄眉眉
Owner NANCHANG HANGKONG UNIVERSITY
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