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A traditional Chinese medicine preparation for treating diabetic neuropathy and its preparation method

A technology of traditional Chinese medicine preparations and neuropathy, which can be applied to nervous system diseases, medical formulas, medical preparations containing active ingredients, etc., and can solve problems such as hypoglycemia, damage to human organs, and delay in illness

Active Publication Date: 2011-11-30
GUIZHOU BAILING GRP PARMACEUTIAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there are many products on the market that add hypoglycemic western medicines to traditional Chinese medicines. Such products are more harmful to patients. Many patients feel that the rapid drop in blood sugar can be controlled after taking certain traditional Chinese medicine products, so they think that this kind of Chinese medicine is the cure. Good medicines for diabetes, but they do not know that there must be western medicine (lowering sugar) ingredients in them. Because the dosage of western medicine (lowering sugar) ingredients is unknown, patients often take double doses when taking it. It is easy to cause hypoglycemia, long-term use can damage human organs and accelerate the occurrence and development of diabetic complications. More importantly, it delays the best time for patients to treat diabetes, delays the disease, and causes greater physical and psychological pain to patients.

Method used

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  • A traditional Chinese medicine preparation for treating diabetic neuropathy and its preparation method
  • A traditional Chinese medicine preparation for treating diabetic neuropathy and its preparation method
  • A traditional Chinese medicine preparation for treating diabetic neuropathy and its preparation method

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Effect test

Embodiment 1

[0243] Embodiment 1: the preparation of capsule

[0244] Raw materials: Salvia miltiorrhiza 612g, Panax notoginseng 136g, silymarin 20g

[0245] Preparation method: take notoginseng and grind it into fine powder, set aside, take Danshen, add 6 times the amount of 85% ethanol to extract twice, each time for 2 hours, filter, combine the filtrate, recover ethanol from the filtrate, add 8 times the amount of water to decoct the dregs Extract 3 times, 1 hour each time, filter, combine the filtrates, concentrate to a relative density of 1.05 at 50°C, combine the concentrated solution and the ethanol extract, dry under microwave vacuum under the condition of -0.06MPa~-0.08MPa to form a dry extract, and pulverize , adding Panax notoginseng fine powder and silymarin, adding auxiliary materials, mixing evenly, packing into capsules, and making 1000 capsules.

[0246] Dosage: Take orally, three times a day, 3 to 4 capsules each time.

Embodiment 2

[0247] Embodiment 2: the preparation of tablet

[0248] Raw materials: Salvia miltiorrhiza 570g, Panax notoginseng 160g, silymarin 30g

[0249] Preparation method: Take Panax notoginseng and grind it into fine powder, set aside, take Danshen, add 4 times the amount of 95% ethanol to extract twice, each time for 3 hours, filter, combine the filtrate, recover the ethanol from the filtrate, add 12 times the amount of water to decoct Extract twice, each time for 0.5 hours, filter, combine the filtrates, concentrate to a relative density of 1.05 at 50°C, combine the concentrated solution and the ethanol extract, dry and pulverize, add notoginseng fine powder and silymarin, add excipients, mix well, press Tablets, made into 1000 tablets.

[0250] Dosage: Take orally, three times a day, 3 to 4 tablets each time.

Embodiment 3

[0251] Embodiment 3: the preparation of dropping pill

[0252] Raw materials: Salvia miltiorrhiza 640g, Panax notoginseng 100g, Silymarin 10g

[0253] Preparation method: take notoginseng and grind it into fine powder, set aside, take Danshen, add 8 times the amount of 75% ethanol to extract once, each time for 3 hours, filter, recover ethanol from the filtrate, add 6 times the amount of water to decoct and extract 4 times , 1.5 hours each time, filter, combine filtrates, concentrate to 50°C relative density of 1.05, combine concentrated solution and ethanol extract, dry, pulverize, add notoginseng fine powder, silymarin and auxiliary materials, and make drop pills according to conventional preparation process 1000 pills.

[0254] Dosage: Take orally, three times a day, 3-4 pills each time.

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Abstract

The invention discloses a traditional Chinese medicine preparation for treating diabetic neuropathy, which is prepared from Chinese medicine raw materials salvia miltiorrhiza, notoginseng and silymarin through alcohol extraction, water extraction and pulverization. The traditional Chinese medicine preparation is a traditional Chinese medicine for treating diabetic neurological complications The new drug has an obvious protective effect on the sciatic nerve after diabetes, can increase the conduction velocity of the diabetic sciatic nerve, has a certain reduction effect on the elevated levels of malondialdehyde (MDA) and sorbitol, and has a certain effect on glutathione peroxidase GSH. The activity of -PX can be obviously improved, and the activity of superoxide dismutase (SOD) can also be improved to a certain extent. The neurological complications of diabetes have a good therapeutic effect, providing a new drug choice for the majority of patients, with fewer types of raw materials and easy control of product quality.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for treating diabetic neuropathy and a preparation method thereof. Background technique [0002] Diabetes is one of the most common chronic diseases. With the improvement of people's living standards, the aging population and the increase in the incidence of obesity, the incidence of diabetes is increasing year by year. The incidence rate of diabetes in China reaches 2%. According to statistics, there are 40 million diagnosed diabetic patients in China, and the number is increasing at a rate of 1 million per year. Diabetes is a metabolic disorder caused by carbohydrate metabolism disorder due to hypofunction of pancreatic islets. Its main features are hyperglycemia, diabetes, polyuria, polydipsia, polyphagia, weight loss, and fatigue. Its main hazards lie in its complications. [0003] Complications of diabetes are...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/537A61K9/48A61P3/10A61P25/00A61K31/357
Inventor 孔德明张永萍徐剑王明强
Owner GUIZHOU BAILING GRP PARMACEUTIAL CO LTD